Xenical is a powerful, specific and reversible inhibitor of gastrointestinal lipases with a long-lasting effect. Its therapeutic effect occurs in the lumen of the stomach and small intestine and consists of the formation of a covalent bond with the active serine site of gastric and pancreatic lipases. The inactivated enzyme loses its ability to break down food fats, which come in the form of triglycerides, into absorbable free fats. fatty acid and monoglycerides. Since unsplit triglycerides are not absorbed, the resulting decrease in caloric intake into the body leads to a decrease in body weight. Thus, the therapeutic effect of the drug is carried out without absorption into the systemic circulation.
Based on fecal fat results, the effects of orlistat begin 24 to 48 hours after dosing. After discontinuation of the drug, the fat content in stool usually returns to pre-therapy levels within 48-72 hours.
Efficiency
Obese patients
In clinical studies, patients taking orlistat experienced greater weight loss compared to patients on diet therapy. Weight loss began within the first 2 weeks after the start of treatment and lasted from 6 to 12 months, even in patients with a negative response to diet therapy. Over the course of 2 years, there was a statistically significant improvement in the profile of metabolic risk factors associated with obesity. In addition, compared to placebo, there was a significant reduction in body fat. Orlistat is effective in preventing weight gain. Re-gain of body weight, no more than 25% of what was lost, was observed in approximately half of the patients, and in half of these patients, no re-gain of body weight was observed or even a further decrease was observed.
Patients with obesity and type 2 diabetes mellitus
In clinical studies lasting from 6 months to 1 year in patients with overweight body or obese patients with type 2 diabetes treated with orlistat experienced greater weight loss compared with patients treated with diet therapy alone. Body weight loss occurred mainly due to a decrease in the amount of fat in the body. It should be noted that before the start of the study, despite taking hypoglycemic agents, patients often had insufficient glycemic control. However, with orlistat therapy, a statistically and clinically significant improvement in glycemic control was observed. In addition, during orlistat therapy, a decrease in doses of hypoglycemic agents, insulin concentrations, and a decrease in insulin resistance were observed.
Reducing the risk of developing type 2 diabetes in obese patients
In a 4-year clinical study, orlistat was shown to significantly reduce the risk of developing type 2 diabetes (by approximately 37% compared to placebo). The degree of risk reduction was even greater in patients with baseline impaired glucose tolerance (approximately 45%). There was greater weight loss in the orlistat treatment group compared to the placebo group. Maintaining body weight at a new level was observed throughout the entire study period. Moreover, compared with placebo, patients treated with orlistat showed a significant improvement in their metabolic risk factor profile.
Pubertal obesity
In a 1-year clinical trial in obese adolescents, orlistat was associated with a decrease in body mass index compared with placebo, which even increased body mass index. In addition, patients in the orlistat group showed a decrease in fat mass, as well as waist and hip circumferences compared to the placebo group. Also, in patients receiving orlistat therapy, there was a significant decrease in diastolic blood pressure compared to the placebo group.
Preclinical safety data
Based on preclinical data, no additional risks to patients were identified regarding the safety profile, toxicity, genotoxicity, carcinogenicity and reproductive toxicity. Animal studies also showed no teratogenic effect. Due to the lack of a teratogenic effect in animals, it is unlikely to be detected in humans.
Pharmacokinetics
Suction
In volunteers with normal body weight and obesity, systemic exposure to the drug is minimal. After a single oral dose of 360 mg, unchanged orlistat could not be detected in plasma, which means that its concentrations are below 5 ng/ml.
In general, after taking therapeutic doses, it was possible to detect unchanged orlistat in plasma only in rare cases, and its concentrations were extremely low (<10 нг/мл или 0.02 мкмоль). Признаки кумуляции отсутствовали, что подтверждает, что всасывание препарата минимально.
Distribution
Vd cannot be determined because the drug is very poorly absorbed. In vitro, orlistat is more than 99% bound to plasma proteins (mainly lipoproteins and albumin). In minimal quantities, orlistat can penetrate red blood cells.
Metabolism
Judging by the data obtained in animal experiments, orlistat metabolism occurs mainly in the intestinal wall. In a study in obese individuals, it was found that approximately 42% of the minimal fraction of the drug that is subject to systemic absorption is accounted for by two main metabolites - M1 (a four-membered hydrolyzed lactone ring) and M3 (M1 with a cleaved N-formylleucine residue).
Molecules M1 and M3 have an open b-lactone ring and inhibit lipase extremely weakly (1000 and 2500 times weaker, respectively, than orlistat). Given this low inhibitory activity and low plasma concentrations (average 26 ng/ml and 108 ng/ml, respectively) after therapeutic doses, these metabolites are considered pharmacologically inactive.
Removal
Studies in normal and overweight individuals have shown that the main route of elimination is excretion of unabsorbed drug in the feces. About 97% of the administered dose of the drug was excreted in feces, with 83% as unchanged orlistat.
The cumulative renal excretion of all substances structurally related to orlistat is less than 2% of the administered dose. The time until the drug is completely eliminated from the body (with feces and urine) is 3-5 days. The ratio of orlistat elimination routes in volunteers with normal and overweight was the same. Both orlistat and metabolites M1 and M3 can be excreted in the bile.
Pharmacokinetics in special clinical groups
Plasma concentrations of orlistat and its metabolites (M1 and M3) in children do not differ from those in adults when comparing the same doses of the drug. Daily fecal fat excretion was 27% of dietary intake during orlistat therapy and 7% when receiving placebo.
Release form
Hard gelatin capsules, No. 1, turquoise, opaque; on the body there is a black inscription "XENICAL 120", on the cap - "ROCHE"; the contents of the capsules are white or almost white pellets.
Excipients: talc - 0.24 mg.
* Pellet composition: microcrystalline cellulose - 93.6 mg, sodium carboxymethyl starch (Primogel) - 7.2 mg, povidone K-30 - 12 mg, sodium lauryl sulfate - 7.2 mg.
Capsule shell composition: gelatin, indigo carmine, titanium dioxide.
21 pcs. - blisters (1) - cardboard packs.
21 pcs. - blisters (2) - cardboard packs.
21 pcs. - blisters (4) - cardboard packs.
Dosage
Long-term therapy of obese or overweight patients, including those with risk factors associated with obesity, in combination with a moderately hypocaloric diet in adults and children over 12 years of age, the recommended dose of orlistat is one 120 mg capsule with each main meal (during during meals or no later than an hour after meals).
In combination with hypoglycemic drugs (metformin, sulfonylureas and/or insulin) or a moderately hypocaloric diet in patients with type 2 diabetes mellitus who are overweight or obese: in adults, the recommended dose of orlistat is one 120 mg capsule with each main meal (during during meals or no later than an hour after meals).
If meals are skipped or if the food does not contain fat, then Xenical can also be skipped.
The drug should be taken in combination with a balanced, moderately hypocaloric diet containing no more than 30% of calories in the form of fat. The daily intake of fats, carbohydrates and proteins must be divided into three main meals.
The effectiveness and safety of Xenical in patients with impaired liver and/or kidney function, as well as in elderly and pediatric patients (under 12 years of age) have not been studied.
Overdose
In clinical studies in individuals with normal body weight and obese patients, single doses of 800 mg or multiple doses of 400 mg 3 times a day for 15 days were not accompanied by the occurrence of significant adverse events. In addition, obese patients have experience using orlistat 240 mg 3 times a day for 6 months, which was not accompanied by a significant increase in the frequency of adverse events.
In cases of overdose of the drug Xenical, either the absence of adverse events was reported, or the adverse events did not differ from those observed when taking the drug in therapeutic doses.
In case of severe overdose of Xenical, it is recommended to monitor the patient for 24 hours. According to studies in humans and animals, any systemic effects that could be associated with the lipase inhibitory properties of orlistat should be quickly reversible.
Interaction
There were no interactions with amitriptyline, atorvastatin, biguanides, digoxin, fibrates, fluoxetine, losartan, phenytoin, oral contraceptives, phentermine, pravastatin, warfarin, nifedipine GITS (gastrointestinal therapeutic system) and nifedipine slow release, sibutramine or alcohol (based on drug interaction studies). However, it is necessary to monitor INR values during concomitant therapy with warfarin or other oral anticoagulants.
When taken simultaneously with the drug Xenical, a decrease in the absorption of vitamins D, E and betacarotene was noted. If multivitamins are recommended, they should be taken at least 2 hours after taking Xenical or before bedtime.
When taking the drug Xenical and cyclosporine simultaneously, a decrease in plasma concentrations of cyclosporine was observed, therefore, more frequent determination of plasma concentrations of cyclosporine is recommended when taking cyclosporine and the drug Xenical simultaneously.
When amiodarone was administered orally during therapy with Xenical, a decrease in the systemic exposure of amiodarone and desethylamiodarone was observed (by 25-30%), however, due to the complex pharmacokinetics of amiodarone, the clinical significance of this phenomenon is not clear. The addition of Xenical to long-term amiodarone therapy may result in a decrease in the therapeutic effect of amiodarone (no studies have been conducted).
The simultaneous use of Xenical and acarbose should be avoided due to the lack of data from pharmacokinetic studies.
Cases of seizures have been observed when taking orlistat and antiepileptic drugs simultaneously. A cause-and-effect relationship between the development of seizures and orlistat therapy has not been established. However, patients should be monitored for possible changes in seizure frequency and/or severity.
Side effects
Clinical trial data
The following categories are used to describe the frequency of adverse reactions: very often (≥1/10), often (≥1/100,<1/10), нечасто (≥1/1000, <1/100), редко (≥1/10000, <1/1000) и очень редко (<1/10000), включая отдельные случаи.
Adverse reactions to orlistat occurred mainly from the gastrointestinal tract and were due to the pharmacological effect of the drug, which interferes with the absorption of dietary fats. Very often, phenomena such as oily discharge from the rectum, the release of gases with some discharge, an imperative urge to defecate, steatorrhea, increased frequency of bowel movements, loose stools, flatulence, pain or discomfort in the abdomen were noted.
Their frequency increases with increasing fat content in the diet. Patients should be informed of the possibility of gastrointestinal adverse reactions and taught how to manage them through better diet, especially regarding the amount of fat contained in the diet. Adopting a low-fat diet reduces the likelihood of gastrointestinal side effects and thereby helps patients control and regulate their fat intake.
As a rule, these adverse reactions are mild and transient. They occurred in the early stages of treatment (in the first 3 months), and most patients had no more than one episode of such reactions.
When treated with Xenical, the following adverse events from the gastrointestinal tract often occur: “soft” stools, pain or discomfort in the rectum, fecal incontinence, bloating, dental damage, gum damage.
Also noted very often were: headaches, upper respiratory tract infections, flu; often: lower respiratory tract infections, urinary tract infections, dysmenorrhea, anxiety, weakness.
In patients with type 2 diabetes mellitus, the nature and frequency of adverse events were comparable to those in individuals without diabetes mellitus with overweight and obesity. The only new adverse events in patients with type 2 diabetes were hypoglycemic conditions occurring at an incidence of >2% and an incidence of ≥1% compared with placebo (which may have resulted from improved carbohydrate compensation) and a common occurrence of abdominal bloating.
In the 4-year clinical study, the overall safety profile did not differ from that obtained in the 1- and 2-year studies. At the same time, the overall incidence of adverse events from the gastrointestinal tract decreased annually over the 4-year period of taking the drug.
Post-marketing surveillance
Rare cases of allergic reactions have been described, the main clinical symptoms of which were itching, rash, urticaria, angioedema, bronchospasm and anaphylaxis.
Very rare cases of bullous rash, increased activity of transaminases and alkaline phosphatase, as well as isolated, possibly serious cases of hepatitis have been described (a cause-and-effect relationship with taking the drug Xenical ® or pathophysiological mechanisms of development have not been established).
With the simultaneous administration of Xenicali anticoagulants, cases of decreased prothrombin, increased international normalized ratio (INR) values and unbalanced anticoagulant therapy have been reported, which led to changes in hemostatic parameters.
Cases of rectal bleeding, diverticulitis, pancreatitis, cholelithiasis and oxalate nephropathy have been reported (incidence unknown).
When taking orlistat and antiepileptic drugs simultaneously, cases of seizures have been observed (see section “Interaction with other drugs”).
Indications
- long-term therapy for obese or overweight patients, incl. having risk factors associated with obesity, in combination with a moderately hypocaloric diet;
- in combination with hypoglycemic drugs (metformin, sulfonylurea derivatives and/or insulin) or a moderately hypocaloric diet in patients with type 2 diabetes mellitus who are overweight or obese.
Contraindications
- chronic malabsorption syndrome;
- cholestasis;
- hypersensitivity to the drug or any other components contained in the capsule.
Features of application
Use during pregnancy and breastfeeding
In animal reproductive toxicity studies, no teratogenic or embryotoxic effects of the drug were observed. In the absence of a teratogenic effect in animals, a similar effect in humans should not be expected. However, due to the lack of clinical data, Xenical should not be prescribed to pregnant women.
The excretion of orlistat into breast milk has not been studied and should not be taken during breastfeeding.
special instructions
Xenical is effective in terms of long-term control of body weight (loss of body weight and its maintenance at a new level, prevention of re-gain of body weight). Treatment with Xenical leads to an improvement in the profile of risk factors and diseases associated with obesity, including hypercholesterolemia, type 2 diabetes mellitus, impaired glucose tolerance, hyperinsulinemia, arterial hypertension, and a decrease in the amount of visceral fat.
When used in combination with hypoglycemic drugs such as metformin, sulfonylureas and/or insulin in patients with type 2 diabetes mellitus who are overweight (body mass index (BMI) ≥28 kg/m2) or obese (BMI ≥30 kg/m2) m 2), Xenical in combination with a moderately hypocaloric diet provides an additional improvement in the compensation of carbohydrate metabolism.
In clinical studies, the majority of patients had concentrations of vitamins A, D, E, K and betacarotene within the normal range during four years of orlistat therapy. A multivitamin may be prescribed to ensure adequate intake of all nutrients.
The patient should receive a balanced, moderately hypocaloric diet containing no more than 30% of calories in the form of fat. A diet rich in fruits and vegetables is recommended. The daily intake of fats, carbohydrates and proteins must be divided into three main meals.
The likelihood of adverse reactions from the gastrointestinal tract may increase if Xenical is taken on a diet rich in fat (for example, 2000 kcal/day, of which more than 30% in the form of fat, which equals approximately 67 g of fat). Daily fat intake should be divided into three main meals. If Xenical is taken with a meal very rich in fat, the likelihood of gastrointestinal reactions increases.
In patients with type 2 diabetes mellitus, a decrease in body weight during treatment with Xenical is accompanied by an improvement in the compensation of carbohydrate metabolism, which may allow or require a reduction in the dose of hypoglycemic drugs (for example, sulfonylurea derivatives).
This tale is about xenical! How to take these diet pills? What do they do? Will a drug that prevents fat from being absorbed from the intestines help you get rid of your own fat deposits? What is better to drink, Orlistat or Xenical, to achieve at least some effect? What precautions are necessary when using Xenical?
Hello friends! In pursuit of a slim figure, we are looking for weight loss drugs that can help us burn off the fat that has accumulated on our sides without the hassle of dieting and fitness. Demand creates supply, and online pharmacies are proliferating products promising “guaranteed weight loss” at a variety of prices. Just pay!
Detailed instructions for use will explain what it consists of, how to drink it, when not to drink it, how many times and on whom it has been tested, and at the same time will include a list of interactions with a dozen medications, the names of which most of us have not even heard of. Is it worth giving in to advertising and buying Xenical? You don't need to become a pharmacist to understand this. It’s enough to turn on the logic, which is what we’ll do now!
Xenical: what is it and how does it work?
Information about the drug can be found in the radar and on any other advertising site.
These are wonderful gelatin capsules of a pleasant turquoise color. They contain a substance called orlistat, exactly 120 mg. in one piece. As an addition, the composition includes:
- microcellulose;
- sodium lauryl sulfate and its carboxymethyl starch;
- povidone;
- in the shell - gelatin, indigo carmine and titanium bleach.
Titanium dioxide, according to research from the University of California, Los Angeles, has the ability to accumulate and affect chromosomes. Nanoparticles of this substance have a negative effect on the body at the cellular level. Of course, their quantity in food products is insignificant, but the accumulation effect can sooner or later play a role. We already consume a lot of bleached products that contain this substance. Whether it is worth adding when taking it along with medications - everyone decides for themselves.
The price in pharmacies for this product starts from 1600 rubles. You can buy in Moscow, through online pharmacies, packs of 21, 42 and 84 capsules. Some will probably start looking for cheap analogues in order to buy at a lower price. But products with orlistat cost about the same.
What does orlistat do in our intestines?
Complex triglycerides, which enter the gastrointestinal tract in the form of dietary fats, are unable to be absorbed. In order to use them, the pancreas produces the enzyme lipase, which decomposes triglycerides into fatty acids and monoglycerides. The final product is absorbed from the intestines into the blood and used by the body.
Xenical is a strong agent for suppressing the activity of the lipase enzyme. Xenical binds to lipase and prevents it from displaying its properties. Unabsorbed fat is transported through the intestines and excreted naturally. I talk about this in lesson No. 7 “Gastrointestinal Tract” in my online Healthy Body Academy.
It would seem that everything is simple and clear. But there is one drawback in this scheme, which advertisers do not say anything about: an excess of undigested fat upsets the natural balance in the intestines. Accelerated evacuation of feces removes beneficial microflora from the large intestine. The presence of a large amount of undigested triglycerides interferes with the absorption of water and vitamins. Lack of sufficient fat is a direct path to hypoxia (oxygen starvation) of internal organs. We can safely say, “Hello ischemia!” And other surprises. The inability to produce the hormone testosterone, which is synthesized from cholesterol (fat), will lead to sexual dysfunction and serious disorders in the endocrine system. Lesson No. 5 “The Next Most Important Functions of Fats” ( Online Healthy Body Academy ).
Efficacy of Xenical
According to the opinion voiced in the instructions for the drug, this substance will help you get rid of a certain amount of kilograms in the first two weeks. Long-term use of orlistat should provide the following:
- improve metabolic processes in the body;
- reduce the amount of fat in the patient’s body;
- get rid of secondary weight gain after the end of treatment (though only in half of the cases);
- improve performance in people with type 2 diabetes (although diabetes is not a problem of fat, but of fast carbohydrates);
- reduce the risk of developing diabetes if you are obese;
- will help fight excess weight during puberty.
Based on these points, the medicine should be used in the following situations:
- for long-term (2 years or more), coupled with diet;
- as an aid in the fight against excess weight in type 2 diabetes.
If you want to test the effect of the drug on yourself, get your doctor’s approval.
How to take Xenical?
The usual regimen for taking this remedy: one capsule (120 mg) with each meal. No later than two hours after the meal.
Overdosing on a substance doesn't change anything, so whether you drink it three times a day, or five times a day, doesn't matter.
If your food does not contain fat or contains a small amount of it, you can skip the capsule. Fat-soluble vitamins, which you will be deficient in, are best taken at night, a few hours after Xenical.
You can't get by just taking orlistat. Along with it, you need to stick to a diet with a low fat content - no more than 30% of other nutrients.
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steatorrhea (fat in stool); flatulence (bloating); involuntary oily discharge from the anus; pain, colic, discomfort; diarrhea; incontinence of intestinal contents; frequent urge to go to the toilet; problems with teeth and gums. There is an opinion that such troubles should happen only in the first three months of using Xenical, and even then in isolated cases. But the experience of those who have taken this drug suggests the opposite: a side effect will certainly occur, will accompany you anywhere and everywhere, and if you’re lucky, then at the most inopportune moments. After all, fat and liquid contents of the intestines will “shoot” out of you with the slightest “fart”.
Weight loss medications are available on the market today in great abundance. These are products that quickly remove water, block the absorption of fats and carbohydrates, and promote the breakdown of subcutaneous fats. Among all this flood of pharmaceuticals, there is practically nothing that would be truly useful for the process of weight loss. Almost the only exception is the drug "Xenical". In the reviews, doctors emphasize that it will not only help you achieve your ideal weight, but also maintain the results for a long time.
Widely known
It's been about 20 years how this drug appeared in Russia. And more than half a century has passed since the release of the first batch. Since then, practically nothing has changed. It has not lost its relevance, and it was not possible to invent a drug that would better cope with its responsibilities for weight loss. Judging by the reviews of doctors, Xenical is the only remedy that they are ready to prescribe to their patients if it is really necessary.
Operating principle
This is the most important point that must be conveyed to the patient before he begins the course of treatment. The drug does not have a systemic effect on the entire body. It only locally blocks the absorption of fats supplied with food. Of course, not everyone. About 30% of what you eat is bound and excreted.
That is, a miracle will not happen. All your subcutaneous fats will remain in place, unless you come to the need to adhere to a diet. And here we can talk about the educational value of Xenical tablets. In reviews, doctors emphasize that this property is significant incentive to stick to the diet.
The fact is that eating fatty foods leads to severe diarrhea. And sometimes this ends with uncontrolled release of feces. Even without talking about the embarrassment this can lead to at work, it becomes clear that many will try to avoid such a situation.
In what cases is the drug prescribed?
Let us immediately emphasize that having 2-5 kg of excess weight is not a reason to drink Xenical. In the reviews, doctors say that in this case there is no need to buy an expensive drug. You just need to contact a competent nutritionist and adjust your diet. Moreover, the treatment still takes place against the background of a diet; the drug only helps make it more effective.
Doctors prescribe Xenical if they are diagnosed with obesity or are clearly overweight. Then the doctor determines the patient’s ability to cope with this problem on his own. Usually the presence of concomitant diseases that limit a person’s activity is a predetermining factor.
The principle of action is that it does not allow the absorption of fats. We have a special enzyme inside us that breaks down lipids. By neutralizing its effect, Xenical makes this process impossible. But you need to understand that this creates certain problems. If substances appear in the intestines that cannot be absorbed and used, they begin to deteriorate and decompose. To quickly get rid of them, a cleansing process is launched.
In this case, it is diarrhea with all the attendants: pain, bloating. Not all patients experience these symptoms, but only a small part, as evidenced by reviews from doctors. “Xenical” for weight loss is also good because it does not penetrate into the blood and has an effect only in the intestines. It can be taken long-term and will not cause addiction.
First of all, you need to visit an endocrinologist. It will help determine the causes of weight gain and correct them as quickly as possible. If this is due to hormonal imbalance, then individual therapy will be prescribed. But most often the problem is a violation of the diet and the balance between consumed and expended calories.
In this case, the patient will be referred to a nutritionist. But a situation where a patient cannot maintain a diet and constantly breaks down is not at all uncommon, according to doctors. “Xenical” for weight loss in this case acts as an incentive and assistant, because:
- the drug was prescribed by a doctor;
- it is quite expensive;
- When using the drug simultaneously and an excess amount of fatty foods, side effects develop.
What do you need to know?
You can find many negative reviews in which people describe a number of side effects experienced while taking the drug. Despite this, doctors' reviews of Xenical diet pills are very good. Experts are confident that if prescribed correctly, it can greatly help the patient. At the same time, the drug is not addictive and does not have an effect on internal organs.
To avoid experiencing side effects, you must follow these rules:
- Overdose is unacceptable. You can take a maximum of 3 capsules per day. Do this during a meal or immediately after it.
- The effect of the drug applies only to fats. Proteins and carbohydrates do not bind and are not excreted.
- If you skipped one meal, then there is no need to take a capsule. It will not affect the body's fat reserves in any way.
- If the meal does not contain fat (vegetable salad, fruit), then skip the capsule. This can be an incentive to optimize your diet, as it helps you save money.
- The effect occurs only with a balanced diet. This is repeatedly emphasized by reviews from doctors. Real reviews "Xenical" is called a nutritionist's assistant. That is, its main task is to teach the patient to eat properly. Let us add that a balanced diet is when fat accounts for 30% of the total calorie content of the dish.
- Don't focus on empty carbohydrates. The drug does not affect them in any way. It is better to diversify your diet with cereals.
After taking the drug, the stool becomes oily, there is a regular urge to defecate, and bloating. All these problems are a reflection of the fact that the fat consumed is excreted and mixed with feces. Once a person switches to a low-fat diet, these problems gradually go away.
Active substance
This is orlistat, which prevents the breakdown of fats. There is nothing else in the composition, which can explain the small number of contraindications. Research shows that 30% of the fat you eat is excreted in your feces. Some people are very surprised that their seemingly balanced diet leads to the release of colossal amounts of oily feces. This means that there is hidden fat in the food. The menu needs to be revised. Taking the drug leads to weight loss by 20-30%.
Side effects of Xenical
In the reviews, doctors note that if all instructions are followed, they are reduced to almost a minimum. But most patients do not come to see a specialist. They go to the pharmacy and buy the drug. Moreover, many of them are sure that it should be taken on days when the diet is relaxed, after a festive feast. Of course, the next day you will experience the following symptoms:
- loose stools;
- pain and discomfort in the abdomen.
Accordingly, the ability to go to work is in question. In addition, the instructions note the possibility of allergic reactions. This may include urticaria, itching and bronchospasm. In very rare cases, women may stop menstruating and experience weakness. All side effects are reversible and disappear after discontinuation of the drug.
Responsible approach to your health
Reviews from doctors and patients about Xenical are very different. Moreover, you can often read negative statements that describe days spent in the toilet and severe pain. The question is: who is to blame for this? The manufacturer or the person himself who did not read the instructions?
It is not designed to combat any case of excess weight. Its effectiveness has been proven only for certain indicators of overweight and obesity. But to lose a couple of kilograms, you definitely shouldn’t use this drug. Very often, patients complain that they had to pay a high price for a pack of pills and at the same time give up sweets and starchy foods. As a result, in a couple of months they got rid of 2-3 kg. But this result could have been achieved without resorting to the drug Xenical.
In the reviews, doctors completely exclude side effects only with proper use. This means that most patients, one way or another, encounter them. That’s why we say that you need to consult a doctor who will select the optimal diet. Separate groups can be divided into patients with the following disorders:
- bulimia;
- kidney stone disease;
- diabetes;
- anorexia.
In any of these cases, the drug is taken under the supervision of the attending physician.
Contraindications
The drug should not be taken during pregnancy and lactation. This treatment is not prescribed to children under 18 years of age. You need to approach treatment very carefully if you have gallbladder diseases. If you have a history of intestinal diseases, you should consult a gastroenterologist. There are certain problems with intestinal malabsorption for which its use is not recommended.
Instructions for use
In reviews, doctors call Xenical a necessary and justified remedy in some cases and unacceptable in others. Therefore, do not self-medicate. The standard course of treatment takes two months. Another important point, since some people decide that they can drink it constantly, removing excess fat from the body.
It can be taken 1 to 3 times a day. If breakfast and dinner are lean, then feel free to skip the capsule. Be sure to drink water. If the capsule is not taken with a meal and more than an hour has passed, delay taking it until your next meal. Fats have already been exposed to enzymes and will be used by the body.
The most interesting thing is that not only patients have an ambiguous opinion about the drug "Xenical". In reviews, doctors sometimes interpret the instructions in their own way, prescribing the drug only to those patients who have a clear excess of fat in their diet.
It should be borne in mind that the drug blocks the absorption of not only harmful substances, but also most fat-soluble vitamins. Therefore, you should definitely include multivitamins in your diet. Otherwise, this may lead to serious health problems. The list of vitamins in the supplement should include D, A, E, K. They should be taken two hours after the Xenical capsule. If this is neglected, fecal incontinence, tooth damage and hair loss, skin itching and decreased immunity, and headaches develop.
Two analogues
Quite often, patients ask the following question: “Xenical or Orsoten - which is better?” Reviews from doctors in this case sound approximately the same. These are two identical drugs. The first to appear was Xenical, which was produced in Sweden. It was distinguished by its high cost; not everyone could afford a course of treatment for 2-3 months. The Russian company solved the need for a cheaper analogue by releasing Orsoten to the market. The main differences between them were the price and color of the capsules.
Both drugs are gastrointestinal lipase inhibitors. The active substance is orlistat. The composition and effect of the drugs are completely identical; one capsule contains 120 mg of active substance. Judging by the reviews of patients, no one noticed a difference in the results either. From this we can conclude that if you are not ready to pay for a brand, then you can safely buy a more affordable option.
Same or different?
There is another weight loss drug on the market today, reviews of which are sometimes like a fairy tale. This is “Reduxin”, which doctors in some cases prescribe to correct obesity. It is used only if all other weight loss measures have not yielded positive results or they are too insignificant.
The drug is very convenient to take, since you only need to take one capsule per day. At the same time, following a diet becomes very easy, since the feeling of hunger goes away by itself. But at the same time, the drug has so many side effects that it is worth considering what to take - “Xenical” or “Reduxin”. Reviews from doctors in this case are rather dry. Experts say it all depends on the patient and the specific disease. It is very difficult to compare them, because one affects at the local level, and the other affects all organs and systems.
Based on this, it is very difficult to say which is better - “Xenical” or “Reduxin”. In the reviews, doctors emphasize that while the first one is still acceptable to take without a doctor’s prescription, in the case of the second one it can seriously harm your health. The active ingredient of Reduxin is sibutramine, a narcotic substance. Under its influence, a person loses his appetite, but develops strong thirst. May lead to disruption of the kidneys and liver, and negatively affects the cardiovascular system.
Instead of a conclusion
The desire to be beautiful and slim is inherent in all women. Moreover, if some of them go to the gym and adhere to a healthy diet, then the other half of the beautiful ladies rely only on miracle pills. These include "Reduxin", but if during treatment you do not learn to build your diet in a new way, then the weight will gradually return again, because the correct eating behavior has not been formed.
In this regard, the drug “Xenical” works much more environmentally friendly. Here the patient immediately has a specific task to review his diet. Otherwise, positive results will be in question. Moreover, there will also be very unpleasant side effects. Many patients note that it was precisely this incentive that they lacked in order to start eating right. After adjusting the diet, the weight gradually began to go away on its own, and the need for the drug disappeared. This is the main task that this medicine must perform. Teach the patient to eat fully but correctly during the treatment period.
Xenical(Xenical) - one of the popular weight loss drugs Swiss pharmaceutical company F.Hoffmann-LaRoche Lt. The action of Xenical is based on blocking the work of lipase, an enzyme that promotes the breakdown of dietary fats to a level at which the body can absorb them. Xenical for weight loss - an inhibitor of gastrointestinal lipases, reduces the number of calories absorbed by the body, preventing the absorption of some fat. The drug is not absorbed into the blood, therefore it does not have a harmful effect on internal organs and is not addictive.
Indications for use of Xenical for weight loss
Xenical for weight loss prescribed to persons suffering from:
- (BMI - body mass index 25 - 30),
- obesity (BMI greater than 0),
- diabetes mellitus,
- arterial hypertension,
- atherosclerosis
or having a risk factor for these diseases. Taking Xenical is combined with a moderately low-calorie diet. The drug blocks the process of fat breakdown; about 30% of consumed fat is excreted in feces without being broken down. By receiving less fat, the body begins to use already accumulated reserves.
Taking Xenical first helps stabilize weight, then, if the recommendations are fully followed, by 20%.
Directions for use and doses
One capsule of Xenical is taken during a meal or an hour after a meal. Taking Xenical for weight loss can be skipped if there is no fat in the food.
You can take three Xenical capsules (120 mg each) per day, each with a glass of water. If a dose of Xenical is missed and more than an hour has passed since a meal, the next capsule should be taken during or after the next meal. You cannot take a double dose of the drug!
Taking Xenical requires a balanced diet, in which fats make up 30% of the total calorie intake. The daily intake of fat must be divided into three main meals and taken with them Xenical for weight loss.
Side effects and contraindications of Xenical
Side effects when taking the drug, they manifest themselves in the intestines - copious discharge of gases (flatulence); oily discharge from the rectum; increased frequency of bowel movements; fecal incontinence; fatty stool. Loose stools, discomfort or abdominal pain may occur. Such phenomena are the result of fat blocking. When food contains a significant amount of fat, side effects are more likely. A low-fat diet significantly reduces the likelihood of side effects.
Contraindications for Xenical- gallbladder diseases, chronic syndrome of impaired intestinal absorption, pregnancy and breastfeeding, age up to 18 years.
Taking the drug is possible under the supervision of a doctor if you have diabetes, kidney stones, bulimia or anorexia, or taking others.
Xenical for weight loss reduces the absorption of fat-soluble vitamins, so additional intake of vitamins E, A, D, K and beta-carotene is possible. Vitamins should be taken once a day, two hours after taking the drug or before bedtime.
Instructions
You need to take Xenical during main meals: 3 times a day, 1 capsule with a dosage of 120 mg. The drug should be taken directly during or after meals, but no later than an hour after finishing the meal. Diabetic patients should take the medicine in a standard dosage. Increasing the recommended dose does not increase the effectiveness of the drug. The duration of treatment with Xenical is determined individually.
Therapy with the drug should be combined with a moderate, balanced diet, the fat content of which should be no more than 30%. Vegetables and fruits must also be present in the diet. Each main meal should contain the same amount of carbohydrates, fats and proteins. You do not need to take the medicine if you eat foods that do not contain fat, or if you skip a planned meal.
People with diabetes may require dose adjustment of antidiabetic medications due to weight loss and improved metabolism. In some cases, during the period of therapy with Xenical, it may be recommended to take multivitamins, which will ensure that the body receives useful substances. They should be drunk no earlier than 2 hours after using the drug for.
Eating foods high in fat - more than 30% of total calories - can lead to side effects from the gastrointestinal tract. Such phenomena are usually mild and observed in the first 3 months of treatment. These undesirable effects can be eliminated by reducing the amount of fat-containing foods in the diet.
When treated with Xenical, oily discharge may appear, which is a result of the action of the active components of the drug. Also, during therapy, side effects may occur in the form of bloating and gases (sometimes with a small amount of discharge). Common side effects include damage to teeth and gums, pain or discomfort in the gastrointestinal tract, frequent urge to defecate, loose stools, and fecal incontinence. In addition, during the treatment period, headaches, weakness, anxiety, menstrual irregularities, allergic reactions, as well as various respiratory tract infections, including influenza, may occur.
