The pharmaceutical market offers a fairly large selection of drugs that provide emergency contraception, but almost all of them contain hormones in large dosages, which negatively affects a woman’s health. In fact, taking such a medicine is a hormonal attack; naturally, it does not go away without leaving a mark on your health. Failures are possible as unpleasant consequences menstrual cycle. One of the drugs that is non-hormonal in nature is, according to reviews, Ginepristone. It belongs to a group of drugs intended for emergency postcoital contraception. Medicine used to prevent unwanted pregnancy during unprotected intercourse. We will tell you about this drug, rules of administration and safety measures.
Application benefits
The main difference from other drugs of similar action is that the described drug is a non-hormonal drug. It has a different mechanism of action. To understand how the medicine works, you need to know how the process of conception occurs. In order for pregnancy to occur and develop normally in the future, the female body produces the hormone progesterone. It is thanks to it that the egg matures and leaves the follicle, and the endometrium changes, preparing for the implantation of a fertilized egg, and muscle tone decreases. Most emergency contraceptives block progesterone and ovarian function, which has negative consequences in the form of menstrual cycle disruptions. "Gynepristone" acts in a different way: the connection between hormones and receptors is blocked. In this case, interaction does not occur, which means conception is impossible. The uterine cavity does not accept the egg, it cannot gain a foothold in the endometrium, and increased muscle tone perceives it as a foreign object and helps it leave the body as quickly as possible. This is confirmed by reviews of gynecologists about the product “Ginepriston”.
Composition and release form
The drug is released in tablet form. Flat-cylindrical tablets of yellow or slightly greenish color, packed in blisters. The main active ingredient is mifepristone, and the auxiliary components are microcrystalline cellulose, sodium carboxymethyl starch and calcium stearate.
pharmachologic effect
"Ginepristone" is a synthetic antigestagenic drug prescribed to prevent unplanned pregnancy in case of unprotected sexual intercourse. The drug is indicated for use only as a last resort. To prevent conception, it is better to use other methods: medications or barriers. Active substance The drug, entering the body before ovulation, prevents the egg from leaving the follicle. In this case, the follicle does not burst and the fertilized egg does not enter the uterine cavity, conception cannot occur. If the medication is taken after ovulation, the detachment process is accelerated, which makes it impossible for the fertilized egg to attach to the uterus. The price and reviews of Ginepristone are presented below.
Onset of action of the drug
The drug acts immediately after use: after two hours, maximum effectiveness is achieved. This indicator persists for the next twelve hours. Then the activity slowly decreases, and after three days complete neutralization and removal from the body occurs.
When does bleeding start?
Within a period of up to five days, scanty or heavy bleeding may appear (this depends on individual health parameters). The nature and duration of bleeding may vary; the norm is considered to be the presence of discharge for up to two weeks. If bleeding continues for 14 days and its intensity does not decrease, and there is also an increase in temperature, you should consult a doctor. The presence of bleeding is not obligatory; it may not exist at all. The hatching of the fertilized egg is almost impossible to track visually, since at this stage of development it is very small. In order to verify this, you need to do an ultrasound or conduct a pregnancy test at home. This is confirmed by reviews and instructions for the drug “Ginepristone”. The price depends on the region and pharmacy chain.
Indications for use
This drug is used by women of reproductive age as an emergency contraceptive measure when hormonal or barrier contraceptives do not give the desired result. This drug is not approved as a permanent means of protecting against unplanned pregnancy. Experts recommend using this drug no more than once over a period of time from 6 to 12 months. The price of Ginepriston, according to reviews, is quite high.
Contraindications
The described drug has a whole list of restrictions for use, therefore, before taking the pill, the patient should carefully read the instructions. Taking the drug is contraindicated in the following conditions:
- Insufficiency of adrenal function.
- Acute kidney or liver dysfunction.
- Chronic renal or liver failure.
- Long-term treatment with glucocorticoid drugs.
- Extragenital pathologies with aggravated course.
- Individual intolerance to the main active component of the drug, allergic reactions to mifepristone synonyms.
Reviews and consequences of taking Ginepristone are of interest to many. Varicose veins, severe lung diseases, chronic obstructive bronchitis, heart rhythm disturbances, chronic heart failure - for all these pathologies this drug is not prescribed or is prescribed with caution. In addition, the drug is contraindicated in patients with a history of hemodynamic disorders or arterial hypertension. This is confirmed by the instructions and reviews for Ginepriston.
Directions for use and dosage
Tablets are taken once: 1 pc. during the first three days after unprotected sexual intercourse. It should be remembered that the earlier you take the pill, the higher its effectiveness will be. The interval between eating and taking the tablet must be at least two hours, otherwise the therapeutic effectiveness of the medicine is significantly reduced. The drug can be taken on any day of the cycle in consultation with your doctor. If you suspect pregnancy (if the pregnancy is already long enough), the medicine should not be taken under any circumstances; you should consult a doctor. At breastfeeding the use of the drug is possible only if the woman stops breastfeeding for a while and transfers the child to artificial nutrition. After taking the pill, feeding should not be resumed for two weeks.
Adverse reactions
According to reviews, while taking Ginepristone, side effects may occur in the form of:
- Nausea and vomiting.
- Severe headaches.
- Refusal to eat.
- Pain in the epigastric region.
- Bloody discharge from the genitals.
- Pain in the lower abdomen, cramps.
- Enlargement of the ovaries and tingling in them.
- Increased body temperature.
- Allergic reactions - urticaria, anaphylactic shock. This is confirmed by the instructions for use and reviews of Ginepristone.
Overdose
Taking more than one tablet at a time is not allowed. An independent increase in the recommended dosage or uncontrolled frequent use can lead to serious consequences:
- Heart rhythm disturbances.
- Severe pain in the lower abdomen.
- Liver and kidney failure.
- Adrenal gland dysfunction.
The appearance of any undesirable manifestations is a reason to immediately consult a doctor. In this case, symptomatic treatment is necessary. This is confirmed by reviews of doctors about Ginepristone.
Drug interactions
In the specialized literature there are no described cases of interaction of this medication with other medicines. If another drug has already been prescribed, but there is a need to take Gynepristone, you should first consult with your doctor. In addition, the tablets are not recommended to be taken together with non-steroidal anti-inflammatory drugs, as they can cause bleeding.
special instructions
As we have already said, Ginepriston (reviews are presented below) is not suitable as a permanent means of contraception. This is an emergency measure if the usual protective measures have failed. This drug is not able to protect against the transmission of sexually transmitted diseases and HIV infection, therefore, if you are not sure about your partner, you should use barrier methods of contraception. It should be recalled once again that the drug is not an abortifacient; if pregnancy has already occurred, the pills cannot be taken.
Storage conditions and price
Ginepristone is sold in pharmacies as prescribed by a doctor. The medicine must be stored at temperature conditions, no more than 25 degrees Celsius, in a dark place protected from access by children. Shelf life is limited to three years from the date of issue. After the expiration date, the drug cannot be used. This drug costs from 400 to 500 rubles per tablet.
For emergency prevention of pregnancy after pregnancy, Ginepristone tablets can be used, which contain 10 mg of mifepristone, a synthetic steroid.
Ginepristone: instructions for use
The package contains 1 or 2 tablets of the drug. Before use, it is important to understand how Gynepristone works: it blocks receptors, disrupting its regulation in the attachment of a fertilized egg, and also disrupts ovulation, which without progesterone slows down significantly. In addition, the drug leads to thickening of the cervical mucus and creates unfavorable conditions for pregnancy in its cavity.
Gynepristone: indications, contraindications, side effects
- The main indication is the prevention of unwanted pregnancy after unprotected sexual intercourse, for which the drug is taken no later than 72 hours after it.
- Contraindications for use: adrenal insufficiency or taking adrenal hormones, in case of heart failure, or a tendency to thrombus formation. Do not use the drug together with non-steroidal anti-inflammatory drugs. You can breastfeed no earlier than 2 weeks after taking Ginepristone.
- Side effects of the drug are headaches and dizziness, vomiting, fever, spotting from the vagina, an allergic reaction to Gynepristone.
- The consequences of an overdose of the drug are adrenal insufficiency.
Often women have a question: Postinor or Gynepriston - which is better for emergency pregnancy prevention? If Postinor contains the natural hormone levonorgestrel, then Ginepristone is a synthetic drug that has fewer side effects. It is more reliable for preventing pregnancy, does not lead to disruption of the menstrual cycle and does not depend on its phase. But if a woman took Gynepristone, but her period was delayed, she must take a pregnancy test and be examined by a doctor.
Each tablet contains 0.01 g of active substance - mifepristone . Also added excipients: 0.0746 g microcellulose , 0.0045 g sodium carboxymethyl starch and 0.0009 g calcium stearate .
Release form
Available in the form of flat-cylindrical tablets of light yellow color, which weigh 0.01 g. Each tablet separately or two tablets together are placed in a blister pack or a polymer jar. Each blister pack or polymer jar is contained in a cardboard pack.
pharmachologic effect
Possesses antigestagenic effect .
Pharmacodynamics and pharmacokinetics
Pharmacodynamics
Ginepristone is a synthetic steroidal antigestagenic drug - it has the property of blocking the action at the receptor level.
Its action stimulates increased contractility myometrium , promotes the release of substances that increase the sensitivity of the myometrium to certain types of hormones. Depending on what phase of the menstrual cycle the drug was taken, it may cause inhibition ovulation , promote change, and also hinder implantation already fertilized egg.
Pharmacokinetics
Maximum concentration in the blood after taking a single dose of 600 mg of the drug is achieved after 1-1.5 hours.
Absolute bioavailability Ginepristone is 69%.
98% of the drug entering the blood binds to plasma proteins, in particular.
Removal from the body is uneven. At first, the concentration is halved slowly (up to 72 hours), then much faster. The half-life is 18 hours.
Indications for use
Gynepristone is used as an interruption, that is, in cases where sexual intercourse was unprotected or if the method of contraception used during it turned out to be unreliable.
Contraindications
Contraindications include:
- presence in the anamnesis of indications of hypersensitivity To mifepristone ;
- adrenal insufficiency and long-term therapy glucocorticosteroids ;
- acute and chronic renal and/or liver failure;
- severe form extragenital pathology .
You should be careful when using Ginepristone when:
- various violations hemostasis (including disorders caused by previous treatment anticoagulants );
- chronic obstruction obvious lung diseases (For example, );
- severe arterial hypertension ;
- heart rhythm disturbances;
- heart failure .
Side effects
Side effects of Ginepristone may include a feeling of discomfort in the lower abdomen, weakness, headache, nausea, vomiting , hyperthermia , bloody discharge from the genital tract may appear.
Instructions for use (Method and dosage)
Take 1 tablet orally no later than 72 hours after unprotected sexual intercourse. Do not eat food for 2 hours before and after taking the drug.
Ginepristone is used in any phase of the menstrual cycle.
Overdose
In cases of taking Ginepristone in doses not exceeding 2 g, adverse reactions are unlikely. When taking a larger dose of the drug, the functioning of the adrenal glands may be disrupted and they may develop. failure .
Interaction
Contraindicated simultaneous use With non-steroidal anti-inflammatory drugs .
Terms of sale
Sold by prescription.
Storage conditions
Should be stored in a dry place protected from light. Temperature environment should not exceed 30 °C. The place where the tablets are stored should be out of reach of children.
Best before date
special instructions
It is not advisable to use regularly as a means of permanent, planned contraception.
One of the main functions of using various protections during sexual intercourse is to prevent unplanned pregnancy. But what to do if contraceptives were not at hand or they turned out to be of poor quality? In these cases, the solution may be so-called post-coital contraceptives, that is, drugs taken after unprotected intercourse. One of the most effective and proven drugs of this type is Ginepristone.
In contact with
Description of the drug and its benefits
Ginepristone is a synthetic steroid drug with a pronounced antigestagenic effect. Its essence lies in blocking the interaction of the hormone progesterone and the receptors that capture it. Due to this, the fertilized egg cannot attach to the endometrium and is soon excreted from the body. If the period of ovulation has not yet occurred, the drug prevents its onset.
Compared to other contraceptives of this kind, the drug has clear advantages. The main thing is the non-hormonal nature of the drug, which avoids problems with the endocrine system when using it. That is, the drug has a milder, but no less effective effect, which has been confirmed by practice.
Important! Another important detail is the absence of gestagenic activity, that is, the use of Gynepristone does not affect the ability to become pregnant in the future.
The pharmacokinetic characteristics of the contraceptive allow it to achieve maximum serum concentration within 2 hours when taking a single dose of 600 mg. At the same time, the connection with proteins is almost 100%. The half-life is about 18 hours. In particular, a decrease in concentration by half occurs between 12 and 72 hours after administration (depending on the organism). The remaining metabolites leave the body much faster - in 7-12 hours.
Indications for use and use
When and how to take postcoital contraceptive? The main indication for use of the drug is emergency contraception after unprotected sexual intercourse or in case of ineffectiveness/damage of other means (for example, perforation (rupture) of a condom). In these cases, to prevent unplanned pregnancy, it is necessary to take Ginepristone as soon as possible, no more than 3 days after coitus.
It is advisable to check the dose with your gynecologist, but in most cases one tablet (10 mg of mifepristone) is sufficient. To achieve the desired effect, it is recommended to avoid eating 2 hours before taking the tablet and for 2 hours after. The dosage can be increased depending on the phase of the cycle. The main reason for this is that ovulation has already occurred. The instructions for use indicate that the maximum safe dose that can be taken is 2 g, but such decisions should be made solely by the supervising physician.
The dosage of the drug should be checked with a gynecologist.
Contraindications and side effects
Like any drug, Ginepristone has a number of contraindications. Among them:
- renal failure;
- liver failure;
- long-term therapy with glucocorticosteroids;
- disruption of the endocrine system associated with the production of estrogen;
- chronic diseases of the genitourinary system;
- hypersensitivity to the components of the drug.
In addition, the contraceptive should be taken with caution if you have problems with the cardiovascular system, such as heart failure or arrhythmia. The medicine is taken under supervision in case of impaired blood clotting, diagnosed chronic obstructive pulmonary disease (COPD), or problems with blood pressure.
When using the drug Ginepristone side effects may also occur. They are mainly caused by a violation of the dosage or dosage regimen. Such conditions include:
- migraine;
- elevated temperature (sometimes up to 39°C and above);
- general weakness;
- nausea, sometimes with vomiting;
- abundant bleeding from the genitals;
- hives;
- menstrual irregularities;
- pain and other manifestations of discomfort in the pelvic area.
Important! When using Gynepristone during lactation it is necessary stop breastfeeding for a period of at least 2 weeks.
Overdose may cause disruption of the adrenal glands. In these cases, mandatory consultation with a specialist and symptomatic treatment are necessary.
Advantages of the drug
Features of use and storage
How often can I use the drug? The use of Gynepristone as postcoital contraception on an ongoing basis is strictly not recommended. Otherwise, the effectiveness of its action is reduced, initially amounting to 98.8%. In addition, the development of adrenal insufficiency and various liver and kidney dysfunctions may be a consequence. During use, driving vehicles and other machinery is permitted.
Important! The drug is used only as a solution to the issue of unwanted pregnancy - it does not function as a barrier to sexually transmitted diseases.
If we talk about the compatibility of the drug with other drugs, the simultaneous use of Ginepristone and non-steroidal anti-inflammatory drugs (NSAIDs, ibuprofen, diclofenac) is not recommended. If such a “neighborhood” is necessary, the dose of NSAIDs must be adjusted. One of the burning questions for female representatives is: “Is Gynepristone sold by prescription or not?” Yes, purchase of the drug requires a prescription, so you should ensure its availability in advance.
The drug belongs to list A. It should be stored in a dark, dry place, at a temperature not exceeding 30° C. The maximum shelf life is 36 months.
To purchase the drug, you must take a prescription from a doctor.
Analogues and comparison with them
Below is a list of the most common analogues of Ginepristone and their relative comparison with it:
- Agesta. It is a complete analogue, that is, it has an absolutely identical composition. Consequently, it has all the advantages and disadvantages of the drug in question. It also loses effectiveness with constant use. The average cost is 130 rubles.
- Ginestril. The drug has a wider list of side effects. The advantage is the extended spectrum of action - it is often prescribed as prevention of uterine leiomyomas, one of the common causes of infertility. The average cost is 5620 rubles.
- Genale. The effect of this drug, when used regularly, is much more serious than the corresponding characteristic of Ginepristone. If pregnancy occurs while using it, there is a high risk of having a child with congenital pathologies. The average cost is 300 rubles.
- Miropriston. It is considered one of the most effective postcoital contraceptives. Under its influence, a sharp contraction of the uterus occurs during the day, which leads to rejection of the fertilized egg. It is not commercially available and is prescribed exclusively by the supervising physician. It has a considerable list of side effects. The average cost is 2200 rubles.
- Mifeprex. The drug is taken only in the presence of a doctor in a medical facility, where the woman spends another 2 hours under observation. The list of contraindications is wider, but it is possible to use it much later than within 72 hours after sexual intercourse. It is, in fact, a method of pharmaceutical abortion, therefore it can only be purchased with a doctor’s prescription. The average cost is 1200 rubles.
- Mytholian. It is almost a complete analogue of Mifeprex, therefore it has a similar type of effect and characteristics. Its use is permitted up to one and a half months after the last menstruation. Distributed in pharmacies only upon presentation of a prescription. The average cost is 1200 rubles.
- Mifotab. Another analogue similar to Mifeprex. Possessing an almost identical composition, it has reduced efficiency(about 80%) and a greater number of contraindications. Available only by prescription. The average price is 2000 rubles.
- Pencrofton. In many ways similar to Ginepriston. It has the same efficiency and similar characteristics. The average cost is 3000 rubles.
Ginepristone, like many of the drugs listed, is sold by prescription at an average price of 430 rubles.
Ginepristone, the instructions for which will be described in detail in the article, is an emergency contraceptive intended to terminate an unwanted pregnancy if sexual intercourse was not protected or was protected by unreliable means of contraception. The product belongs to the group of gestagens. Before using the drug, it is important to read the instructions, the contents of the tablets, possible side effects and reviews from women who have tried the drug on themselves.
Release form and composition of the drug
Ginepristone is sold in pharmacies in the form of flat-cylindrical tablets, colored light yellow with a greenish tint. There are three types of packaging in which the drug can be found: strip packaging, a polymer jar or a cardboard box. Any of the offered packages contains up to two tablets of the product.
Active substance , contained in one tablet, allows you to terminate pregnancy at the initial stages. The following substances are indicated as auxiliary components in the instructions:
- microcrystalline cellulose;
- sodium carboxymethyl starch;
- calcium stearate.
pharmachologic effect
The drug is intended for cases where it is urgently necessary to prevent pregnancy. The chemical structure of mifepristone molecules allows us to speak of Ginepristone as a synthetic steroid drug. In the human body naturally Steroid hormones are produced by the adrenal glands.
Mifepristone, penetrating into a woman’s body, instantly blocks the receptors of progesterone, a hormone that helps female body create all conditions for the successful formation and course of pregnancy. Deprived of progesterone, the uterus is unable to provide the favorable environment necessary for the egg to fertilize, the mucus on the cervix thickens, and some changes occur related to its functional layer. As a result of the processes occurring, the egg is unable to attach to the walls of the uterus.
In addition, the instructions for use state that the drug slows down ovulation. Ovulation is the process when an egg is released from a mature ovarian follicle, which subsequently enters the fallopian tube, where it is fertilized. During normal operation reproductive system Ovulation occurs regularly every 19-45 days, depending on the menstrual cycle and the characteristics of the woman’s body.
Indications for use
Taking the drug is indicated if there is a risk of unwanted pregnancy after unprotected sexual intercourse or unreliable means of contraception. Due to its pharmacological properties, the drug allows you to stop the process fertilization of the egg. Reviews strongly recommend taking the product within three days after sexual intercourse, while it is possible to prevent fertilization of the egg. The most favorable time to take a pill is two hours before a meal or two hours after it.
Gynepristone: contraindications
The drug has a large list of contraindications, so you should read the instructions and reviews before starting medication use. The list of contraindications includes factors such as:
If the drug is taken by a woman during lactation, breast milk can be given to a child only after two weeks after taking a contraceptive. It is prohibited to use the medication during pregnancy.
Gynepristone: side effects
Gynepristone, whose side effects occur infrequently, has an effect on the body that sometimes leads to to the following unfavorable factors:
However, often taking the drug turns out to be painless and does not cause discomfort to the woman, which is confirmed by numerous reviews about the medication. Before using a contraceptive to terminate a pregnancy, you should consult a qualified gynecologist and find out the possible risks of side effects.
Directions for use and overdose
The drug should be taken no later than three days after sexual intercourse. It is advisable to take a tablet two hours before starting a meal or two hours after it. The medication has no or minimal effect on the menstruation process, so you can take the pills at any time, regardless of your cycle. The product should not be used as a primary contraceptive for continuous protection of sexual intercourse.
A dose of the drug up to two grams is considered safe for human body. As a result of an overdose, there is a risk of adrenal insufficiency. In this case, it is necessary to begin appropriate treatment.
Gynepristone: analogues
The drug has a large number of analogues containing the same active substance, the action of which is also aimed at emergency protection against unwanted pregnancy. Among the most popular and effective analogues are the following drugs:
- mifepristone;
- mytholian;
- Mifeprex;
- agesta;
- and others.
Reviews about the drug
Gynepristone, reviews of which are mostly positive, has been tried by thousands of women and is recommended to their friends. as an effective emergency contraceptive.
During sexual intercourse, my partner’s condom broke, and since pregnancy is now extremely undesirable for me, I had to buy a contraceptive that would quickly eliminate all risks. The pharmacy recommended this drug. The instructions indicate to take within three days after sexual intercourse. I was afraid of adverse effects on the body, but everything worked out. The product worked and left no negative consequences.
A favorite remedy for unwanted pregnancy when sexual intercourse occurs without contraception or it turns out to be unreliable. It acts gently, does not disrupt the cycle, periods come on time, and there are no troubles in the form of pain in the lower abdomen or headaches.
I purchased the drug when I encountered damage to the condom during sexual intercourse with my partner, after reading reviews about the drug. Most frightening were the comments about negative action on the body, but since there were more than half of purely positive opinions, I decided to try it. I was worried that my condition would worsen after taking the pill, but nothing happened, everything was fine. By the way, I took the product in the first days of menstruation, and it had no effect on the discharge.
Gynepristone is an effective contraceptive that helps a woman in emergency cases when sexual intercourse was unreliably protected or not protected at all. The drug causes abortion at the earliest early stages. The instructions describe in detail all aspects of taking the drug, and reviews confirm the effectiveness of the medication.
