Every girl, without exception, dreams of having a slim or toned body and makes attempts to combat excess weight. Often, it is necessary to reduce body weight for medical reasons, and then, in addition to diets, special medications may also be required, one of which is Reduxin. The contraindications and harms of this medicine are actively discussed by doctors and patients, and it, like any other medicine, should not be taken without consulting a specialist.
Description
The drug "Reduxin" is a drug for the treatment of obesity, the main active ingredient of which is sibutrabine hydrochloride.
While taking the drug, metabolism increases and energy consumption increases. The medicine suppresses the feeling of hunger and appetite, thanks to which, any, even the most strict diets easily carried.
"Reduxin" is a popular and widespread weight loss drug on the domestic market and is available in the form of capsules, which contain white-yellow powder inside.
Worth knowing! The drug is available in various dosages of the active substance, most often 10 and 15 mg.
In addition to suppressing hunger and significantly reducing appetite, the drug also affects fatty tissue, promoting more fast weight loss. The medication affects the central nervous system and brain, so taking it, especially if the recommended dosage is exceeded, can cause various side effects.
Important! In some cases, the use of Reduxin for weight loss and treatment of obesity is strictly contraindicated; moreover, it is not compatible with many medications, especially antipsychotics and sedatives.
Before taking the drug, you should undergo a full medical examination and consult with a nutritionist and your doctor.
Release forms
The drug "Reduxin" is available in various forms, differing in composition and action. In pharmacies you can find the following versions of the drug:
Composition and action
The main active ingredients of the drug "Reduxin" are:
- Sibutamine hydrochloride at a dosage of 10 or 15 mg;
- Microcrystalline cellulose – 158.5 mg.
In addition to the active ingredients, the capsules also contain:
- gelatin;
- calcium stearate;
- titanium dioxide;
- azarubine;
- proprietary blue dye.
The operation of the central nervous system is based on the creation and transmission of electrical impulses between neurons through special processes of various lengths and branches - dendrites and axons. This transmission is ensured by special substances called neurotransmitters, which affect the speed of signal transmission. These substances accumulate in nerve cells and are released only when a signal passes through a specific part of the nervous system, preserving the path along which the signal passed so that the response from the cerebral cortex is received in the same place from which the request came.
Worth knowing! The signal path in the nervous system created by neurotransmitters is called a synapse.
Neurotransmitters include many hormones, including norepinephrine and serotonin, which can not only create a synapse from a nerve cell, but also undergo reuptake, that is, return back to the cell from which they were previously released.
Sibutramine is a reuptake inhibitor and prevents the absorption of neurotransmitters into the processes of nerve cells, due to which the amount of norepinephrine and serotonin in the intercellular space and blood flow sharply increases.
Thus, sibutramine provides:
- dulling of hunger;
- acceleration of saturation;
- stimulation of metabolism (acceleration of metabolism);
- activity of the cardiovascular system;
- increase in thermal production;
- decreased levels of triglycerides, total cholesterol and uric acid in the blood serum;
- destruction of brown adipose tissue.
Microcrystalline cellulose is an active enterosorbent with a detoxifying effect. This element of the Reduxin drug is capable of binding and removing toxic substances, pathogenic microorganisms and their metabolic products from the body:
- xenobiotics;
- allergens;
- toxins of endogenous and exogenous nature;
- excess metabolic products;
- metabolites.
Indications
Considering that Reduxin is a potent drug sold by prescription, it should be taken if there are special indications.
The drug is prescribed for weight loss in conditions such as:
- Nutritional obesity with a body mass index of 30 kg/m² and above.
- Alimentary obesity with a body mass index of 27 kg/m² and higher in the presence of risk factors caused by excessive body weight (lipid metabolism disorders, type 2 diabetes mellitus, etc.).
Worth knowing! Body mass index is a special indicator developed by the Belgian sociologist and statistician Adolphe Quetelet in 1869 and used in official dietetics and medicine. The formula used to calculate BMI is weight/twice height in meters.
Often the drug is used by patients with a lower BMI than indicated by the manufacturer in order to obtain desired weight and figure, however, in any case, its use must be agreed with a specialist.
Important! Doctors prescribe Reduxin only when other weight loss methods have not provided the required result, and excess body weight threatens the patient’s health.
Contraindications
Considering the active effect of the drug "Reduxin" on the central nervous system, there are a number of contraindications for which taking the drug is strictly prohibited:
- Increased individual sensitivity to any of the ingredients of the drug.
- The presence of organic causes of excess weight (for example, hormonal disorders, hypothyroidism, etc.);
- Eating disorders – anorexia or bulimia arising from nervous disorders.
- Mental illnesses and disorders.
- Generalized tics (Gilles de la Tourette syndrome).
- Taking some medicines.
- Diseases of the cardiovascular system, including chronic heart failure, congenital heart defects, ischemic disease, arrhythmia and tachycardia. Peripheral arterial diseases, cerebrovascular diseases.
- Arterial hypertension (pressure more than 145/90 mmHg).
- Thyrotoxicosis.
- Pheochromocytoma.
- Severe liver or kidney dysfunction.
- Angle-closure glaucoma;
- Benign prostatic hyperplasia.
- Any addiction (medication, alcohol, drugs).
- Children's and elderly age(the drug is prohibited for use by persons under 18 and over 65 years of age).
In some situations, the drug "Reduxin" is used with extreme caution:
- presence of arrhythmia in the anemnesis;
- diseases of the coronary arteries, including previous ones;
- neurological disorders and disorders (delay mental development, convulsions, etc., including those suffered previously);
- mild to moderate disorders of the liver and kidneys;
- history of verbal and motor tics;
- cholelithiasis;
- controlled arterial hypertension.
Important! Taking the drug "Reduxin" is strictly contraindicated during pregnancy and breastfeeding, since there are no studies on the safety of its effects on the body of the mother and fetus during this period. Contraception should be used while taking the drug.
Side effects
According to the results of studies, including post-marketing studies, taking the drug "Reduxin" may be accompanied by some side effects. Undesirable manifestations associated with taking weight loss capsules are most pronounced on initial stage therapy and become weaker over time. In most cases, such effects are reversible and are not particularly severe.
Side effects of the drug may include the following symptoms:
- From the central nervous system:
- dry mouth;
- insomnia;
- headache;
- dizziness;
- anxiety;
- change in taste sensations;
- paresthesia;
- convulsions;
- short-term memory impairment.
- From the cardiovascular system:
- tachycardia;
- feeling of heartbeat;
- increased blood pressure;
- atrial fibrillation.
- From the gastrointestinal tract and digestive system:
- loss of appetite;
- constipation;
- nausea;
- exacerbation of hemorrhoids;
- diarrhea;
- vomit;
- urinary retention.
- From the skin:
- increased sweating;
- dysmenorrhea;
- swelling;
- purpura (bleeding into the skin);
- alopecia (hair loss).
- From the immune system:
- allergic reactions;
- hives;
- rashes;
- anaphylactic shock.
- From the mental side:
- suicidal feelings;
- psychosis;
- manic tendencies.
- From the visual organs:
- blurred vision;
- From the reproductive system:
- ejaculation disorder;
- lack of orgasm;
- impotence;
- female cycle disorders;
- uterine bleeding.
In addition to the described side effects during therapy with Reduxin, the following are also possible:
- flu-like syndrome;
- pain in the back and abdomen;
- paradoxical increase in appetite;
- increased thirst;
- rhinitis;
- drowsiness;
- depression;
- nervousness and irritability;
- increased liver enzymes in the blood;
- bleeding;
- acute nephritis.
Benefits and harms
The drug "Reduxin" has a number of useful properties:
Worth knowing! Taking Reduxin capsules ensures slow and gradual weight loss of up to 1 kg per week, and therefore does not create stress for the body caused by sudden changes in body weight.
Taking the drug is accompanied by a change in eating habits, patients begin to eat less and the need for food gradually decreases, so even after the end of Reduxin therapy, weight loss results persist for a long time.
Among the advantages of the drug, one can also note its ease of use (one capsule per day) and lack of addiction.
Despite the large number of advantages, the drug "Reduxin" is made on the basis of a potent chemical substance and can cause some harm to the body, especially if taken uncontrolled, in excess of the dosage and treated without consulting a doctor and prior medical examination.
According to the observations of doctors and patients, Reduxin therapy is accompanied by:
- Negative changes in the composition of the blood.
- Increased risk of strokes and heart attacks, especially in patients with a tendency to cardiovascular diseases.
- Lots of side effects.
- Deterioration of general condition and well-being.
- Irritability and nervous disorders.
Worth knowing! During animal studies conducted over two years, it was found that in male rats on which the drug was used, the incidence of benign tumors increased significantly, and the offspring of rabbits were born with noticeable anomalies.
Sibutramine, on the basis of which the drug "Reduxin" was created, is a potent psychotropic substance that has a tonic effect on the central nervous system, like a narcotic substance. As a result, the use of the drug does not stimulate weight loss, but creates a psychological state in which energy appears and appetite decreases.
Important! In 2010, the drug Reduxin was withdrawn from the American pharmaceutical market due to minimal effectiveness and a high risk of hazardous consequences for health in general and the cardiovascular system in particular.
Instructions for use
Reduxin capsules are intended for oral administration. They should be swallowed whole, without chewing or opening, with a significant amount of water.
Take 1 capsule per day, in the dosage prescribed by your doctor, starting with a minimum dose of 10 mg.
Worth knowing! If after a month of taking the drug the results of therapy are unsatisfactory and body weight has decreased by less than 5%, the dosage is increased to 15 mg.
The total duration of treatment for significant obesity should not exceed two years, since there is no data on the safety of taking the drug for a longer period of time.
If within three months the total body weight has not been reduced by 5% of the initial weight. treatment with Reduxin is canceled and another drug is selected.
Important! Therapy for obesity and weight loss with the use of the drug "Reduxin" should be carried out as prescribed and under the supervision of an experienced doctor. Treatment is combined with dietary nutrition and physical activity.
The instructions for the drug indicate that it can be taken on an empty stomach or immediately before meals. According to reviews, the greatest effectiveness of Reduxin is observed when taking the capsule in the middle of the day, since only in this case the feeling of hunger is suppressed until the evening.
special instructions
The drug "Reduxin" is used as part of complex therapy for obesity along with special dietary nutrition and physical exercises recommended by a specialist.
Exist special instructions things to consider while taking the drug:
- During treatment you should measure arterial pressure and heart rate. In the first months of treatment every two weeks. Then monthly. If the blood pressure level exceeds 145/90, the drug should be discontinued.
- Taking the drug "Reduxin" is prohibited in combination with therapy with MAO inhibitors (ephedrine, ethylamphetamine, fenfluramine, etc.), as well as other medicines, affecting the central nervous system, including antipsychotics and antidepressants, medications for sleep disorders and any other weight loss drugs that have a central effect. You can start Reduxin therapy no earlier than two weeks after taking such medications.
- When taking antiarrhythmic drugs, gastrointestinal motility stimulants, hypokalemia and hypomagnesemia at the same time, Reduxin is used with extreme caution.
- During therapy, you should pay attention to the occurrence of such undesirable symptoms as dyspnea (breathing problems), chest pain, swelling of the legs, but the relationship between the occurrence of such manifestations and taking Reduxin has not been proven.
- If you miss another dose of the drug, you should not take a double dosage at the next dose. Treatment continues according to the regimen prescribed by the doctor.
- Operating vehicles and machinery, as well as engaging in other activities that require concentration, should be done with extreme caution during Reduxin therapy.
Unfortunately, not everyone can cope with excess weight only with the help of diets and physical exercise. People who are obese often have to resort to medications. Modern official medicine does not have many means in its arsenal to combat overweight bodies. These include Reduxin. Why is this drug banned throughout the civilized world and is it worth taking for weight loss?
How dangerous is obesity and how to diagnose it yourself?
People with excess body weight can determine for themselves how much excess fat deposits threaten their life and health. To do this, you just need to measure your waist circumference. If the value exceeds 88 cm in women and 102 cm in men, this indicates obesity and is a serious reason for a radical change in lifestyle, as well as for immediate treatment. medical care. Morbid obesity is especially dangerous when the body mass index, defined as the ratio of the patient’s weight in kilograms to his height in meters, reaches 40–50 kg/m2. It will no longer be possible to cope with this condition on your own; besides, obesity can hide such serious diseases as:
- hypertension;
- atherosclerosis;
- stones in the kidneys;
- diabetes;
- oncology.
Diagnosing obesity is easy with a measuring tape
Only an experienced specialist, having carried out full examination, having established the degree and cause of obesity, can select an adequate treatment for this disease.
Indications for taking Reduxin
A doctor may prescribe Reduxin if the patient has:
- nutritional (or primary) obesity caused by excess caloric intake of food combined with low physical activity, but only if the body mass index is equal to or exceeds 30 kg/m2;
- diabetes mellitus of the second type, accompanied by obesity and dyslipidemia (impaired fat metabolism), if the body mass index is equal to or exceeds 27 kg/m2.
What is the effect of the drug based on?
Reduxin is not a harmless dietary supplement. This is a serious drug produced by domestic manufacturers to combat obesity, but not several extra pounds. In the case of Reduxin, self-medication is unacceptable - the product contains the potent substance sibutramine, which has a number of side effects and contraindications.
The mechanism of action of the drug is based on the complex effect of two active ingredients - sibutramine and microcrystalline cellulose. The first substance suppresses the feeling of hunger by sending appropriate signals to the area of the brain responsible for satiety. And the second removes all toxins from the body.
Reduxin contains sibutramine and microcrystalline cellulose, which block the feeling of hunger
Sibutramine, influencing serotonin and adrenergic receptors, helps cope with excessive appetite and causes a feeling of satiety even when eating small portions of food. This component has another important property - it enhances thermogenesis. This is why many patients feel a surge of warmth after taking Reduxin. If you have a significant amount of extra pounds, as a rule, metabolic processes are violated, the body does not spend fat on energy production, but stores a significant part of it “in reserve.” Under the influence of sibutramine, the layer of dangerous visceral brown fat, which interferes with the normal functioning of internal organs, begins to decrease. Along with this, the level of total cholesterol, as well as bad cholesterol containing low-density lipoproteins, decreases in the blood. But the level of good cholesterol, which is responsible for cleaning blood vessels and transporting bad cholesterol to the liver, on the contrary, increases. Another useful bonus from sibutramine is the normalization of sugar and uric acid levels, an excess of which often causes joint pathologies, urolithiasis and gallstone diseases.
The second active component is microcrystalline cellulose. Swelling in the stomach and filling its space, the substance allows the patient to feel full even without eating. Being an enterosorbent, cellulose binds and removes waste, toxins and allergens from the body.
Long-term practice of using Reduxin has proven the effectiveness of the drug in the fight against obesity. A course of capsules helps to get rid of excess fat deposits smoothly and systematically: the average rate of weight loss is 1–2 kilograms per week.
Video: mechanism of action of Reduxin
Contraindications, precautions and possible side effects when taking
Due to a wide range of cardiovascular and other contraindications, sibutramine is prohibited in many countries of the world, including the United States and the European Union, but is approved for targeted use in the Russian Federation under the supervision of doctors.
Due to the impressive list of contraindications, self-medication with Reduxin is unacceptable
In addition to any cardiovascular diseases that most obese patients suffer from, there are many other contraindications to taking the drug:
- increased sensitivity or individual intolerance to any of the components of the drug;
- hormonal disorders, including hypothyroidism, thyrotoxicosis, etc.;
- neurological eating disorders (anorexia, bulimia);
- presence of mental illness;
- generalized, motor and verbal tics;
- mental retardation;
- convulsions;
- epilepsy;
- taking antidepressants, sleeping pills with tryptophan and antipsychotics;
- taking phentermine, fenfluramine, dexfenfluramine, ethylamphetamine, ephedrine and other monoamine oxidase inhibitors;
- kidney and liver diseases;
- prostate problems;
- pheochromocytoma;
- glaucoma;
- alcohol, drug or pharmacological addiction;
- pregnancy and lactation;
- age under 18 and over 65 years.
The drug is prescribed with extreme caution and taken strictly under medical supervision if the patient has:
- any other neurological disorders;
- tendency to bleed;
- blood clotting disorder.
Before starting a course of taking Reduxin, you must undergo an appropriate examination and inform your doctor about taking any medications, since this remedy incompatible with many of them. These include some antibiotics, analgesics, anti-migraine drugs, drugs that affect hemostasis or platelet function, and many others.
Women of childbearing age while taking Reduxin should use effective means contraception - pregnancy during this period is extremely undesirable.
Driving a vehicle should be treated with extreme caution - the body's reaction to the drug may be unpredictable, as sibutramine can cause poor coordination, slower reactions and a feeling of drowsiness.
List of possible side effects The drug is no less impressive than the list of contraindications, especially for the first 4 weeks:
- headaches and dizziness;
- paresthesia, characterized by numbness, tingling, goose bumps on the skin, as well as taste disturbances;
- anxiety, sleep disorders, depression, increased irritability;
- drowsiness or emotional lability;
- psychosis, thoughts of suicide, mania;
- memory impairment;
- blurred vision, accompanied by a feeling of a veil before the eyes;
- tachycardia and surges in blood pressure;
- atrial fibrillation;
- relaxation of the muscle layer of the walls of blood vessels (vasodilation), accompanied by swelling and redness of the face, etc.;
- constipation or diarrhea;
- convulsions;
- nausea, vomiting;
- dry mouth;
- feeling of thirst, increased or complete loss of appetite;
- exacerbation of hemorrhoids;
- increased sweating;
- redness and itching of the skin;
- urticaria, Quincke's edema and anaphylactic shock;
- pain in the back and stomach;
- acute nephritis;
- urinary retention;
- bleeding or bleeding into the skin;
- increased liver enzymes in the blood;
- a decrease in the number of platelets, accompanied by increased bleeding and blood clotting disorders;
- alopecia (hair loss);
- sexual disorders, expressed in impaired ejaculation or orgasm, impotence;
- uterine bleeding and menstrual irregularities.
Many of the above manifestations can be directly related to a violation of the Reduxin dosage. Any undesirable reaction of the body to the drug should be reported to your doctor immediately. Based on this, the doctor can adjust the regimen for taking the drug or cancel it altogether.
In cases of overdose, it is necessary to rinse the stomach and take sorbents.
Reduxin or Reduxin Light: what is the difference?
If Reduxin is a drug based on sibutramine and microcrystalline cellulose, then Reduxin Light is a dietary supplement, the active component of which is a completely different substance - conjugated linoleic acid. Essential polyunsaturated fatty acid actively prevents accumulation subcutaneous fat, accelerates metabolic processes and stimulates the synthesis of proteins that promote muscle growth. The vitamin E contained in the supplement binds and removes free radicals from the body, thereby preventing the development of cancer. The supplement has a much smaller list of contraindications than the drug of the same name:
- children and adolescents under 18 years of age;
- pregnant and lactating women;
- persons with individual intolerance to any of the components of the drug.
Reduxin Light is a dietary supplement based on conjugated linoleic acid and vitamin E
Despite the fact that Reduxin Light is just a food additive, the drug is not so harmless and requires strict adherence to dosage and other precautions:
- It is better to avoid taking the drug if you have any diseases of the heart or blood vessels;
- During therapy with a dietary supplement, blood sugar levels should be monitored, as there have been cases where long-term use of linoleic acid provoked the onset of diabetes mellitus, as well as the formation of kidney and gallstones.
Rules for taking weight loss drugs Reduxin and Reduxin Light
The regimens for taking the anti-obesity medications under consideration are significantly different.
Reduxin
The drug is taken once a day, in the first half of the day, regardless of food intake, strictly in the dosage established by the doctor depending on the medical history. Take the capsules with a glass of plain water. It is recommended to start taking Reduxin with 10 mg. If poorly tolerated, the daily dose can be adjusted downward to 5 mg up to complete cancellation drug.
If the medicine is well tolerated, but after taking 10 mg capsules for 4 weeks, body weight decreases by less than 2 kg, then it makes sense to increase the dosage to 15 mg.
In addition to poor tolerability, the course of taking Reduxin is stopped in cases where:
- during 3 months of therapy, the patient was unable to reduce weight by at least 5% of the initial weight;
- Having achieved a sufficient reduction, body weight again increased by 3 kg or more.
The duration of therapy with Reduxin cannot exceed 1 year, otherwise the drug may be unsafe.
Reduxin alone is not a panacea for obesity - the process of losing weight needs to be approached comprehensively. Sustained weight loss is impossible without changes in eating behavior and adequate physical activity.
Aerobic and cardio exercises promote effective burning of excess fat deposits
Reduxin Light
Reduxin Light is taken during each meal, 1-2 capsules, but no more than 6 capsules per day. A course of taking the dietary supplement can last for 1–2 months, depending on tolerability and goals. If necessary, taking the drug can be resumed, but not earlier than after a month. Linoleic acid therapy is allowed 3-4 times a year.
As in the case of the drug of the same name, you should not place high hopes on just one supplement - there is no magic pill for obesity. Only a balanced diet and intense training can lead to the desired result. And Reduxin Light, as an adjuvant, will only help speed up the process a little. With an integrated approach to the problem of obesity, you can lose up to 5 kg per month with the help of a supplement.
Review of analogues
In addition to Reduxin, there are other drugs containing sibutramine. Let's look at some of them.
The most famous remedy, the German Meridia, was discontinued due to the high risk of causing heart attacks and strokes. The same fate befell the Indian Slimia and the Czech Lindaksa.
Goldline
A drug produced by the Indian pharmaceutical company Ranbaxy and the domestic Izvarino. This remedy has the same indications, contraindications and side effects as Reduxin. It differs from the latter in its much lower price and in that there is only one active ingredient - sibutramine. According to reviews from patients with normal tolerance, the drug really suppresses appetite. And with this product you can lose an average of 1 to 3 kg per week.
Goldline is a one-component capsule preparation with sibutramine
Goldline Plus
This anti-obesity remedy is produced by the same pharmaceutical companies as Goldline, but it already contains two active ingredients - sibutramine and microcrystalline cellulose. Goldline Plus is almost a complete analogue of Reduxin, with the only difference being that the price of the former is significantly lower.
Two-component capsule drug for obesity with sibutramine and microcrystalline cellulose
Both products are available in the form of 10 mg and 15 mg capsules and are intended for the treatment of second and third degree obesity.
It is worth noting that the same pharmaceutical companies produce the dietary supplement Goldline Light, which, like Reduxin Light, has nothing to do with the drugs of the same name. The action of the supplement is based on L-carnitine-L-tartrate and alpha-lipoic acid. This drug is intended for patients struggling with excess body weight through active physical activity.
What do doctors say about sibutramine?
All doctors are of the same opinion: it is necessary to use drugs based on sibutramine strictly as prescribed and under the supervision of specialists.
Professor, endocrinologist, director of the Institute of Diabetes Marina Shestakova believes that prescribing drugs that affect the brain must be extremely careful, especially since it is unacceptable to self-medicate. Sibutramine therapy should be carried out strictly under the supervision of the treating doctor.
Alexander Myasnikov, chief physician of the Kremlin hospital and a reputable TV presenter, gives sibutramine a very negative assessment. The doctor calls it a crime to produce drugs based on this substance and their uncontrolled sale by pharmacies. Moreover, such means are prohibited throughout the civilized world.
Video: opinion of leading doctors on drugs based on sibutramine
Doctor of Medical Sciences, TV presenter Elena Malysheva believes that sibutramine can only be prescribed to those obese people who suffer from food addiction and are unable to get enough of a small amount of food. In the Channel One television project “Drop the Extra Thing,” a group of patients lost weight with the help of Reduxin. Many of them successfully completed the task and achieved good results. But any pills are powerless without changing eating behavior.
Video: Dr. Elena Malysheva about Reduxin
There are only a few approved drugs for obesity, and they all act differently. Find out about them from a video from endocrinologist, Professor Ekaterina Troshina.
What woman does not dream of having a slim and fit figure, and without making any effort. Today, more and more people, instead of going to the gym and following, prefer an easier way to lose weight - they start taking special pills.
Reduxin is considered one of the most effective and efficient means for weight loss. Reviews about this drug are mostly positive. This medication helps control appetite and stabilizes metabolic processes, so the pounds begin to quickly fall off. But before starting therapy, you need to figure out how to take Reduxin so as not to harm your health.
Reduxin and Reduxin Light are Russian-made products developed specifically for the treatment of obesity and weight loss. The main active component of the drug is sibutramine - this compound blocks the feeling of hunger and allows you to get enough of it in minimal portions.
As a result of this impact, a person begins to eat not only less, but also less often. A loss excess weight in this case, it happens quite quickly, since the intake of calories decreases several times.
The positive effect of Reduxin is also achieved due to the fact that the product normalizes metabolism and increases energy consumption.
As a result, the body’s heat transfer increases and fat deposits begin to burn quickly.
If you decide to take the drug Reduxin, most doctors advise you to simultaneously change your diet and stop consuming “harmful” foods, since this will make the process of losing weight much faster. In addition, moderate physical exercise.
Important! Since the tablets contain a toxic compound, they are only available with a prescription.
Indications for use
Since some pharmacy chains sell this product without a prescription, today everything more women resort to using it. But doctors warn that illiterate use of Reduxin can cause side effects and negatively affect health.
The drug is allowed to be taken only if there are absolute indications:
- Severe obesity, in which the body mass index exceeds 30 kg/m2
- Obesity with an index of 27 kg/m2 or more, if a person has elevated sugar levels.
If a woman dreams of getting rid of several kilograms, there is no point in taking such a remedy. A more suitable option in this case would be to adjust the diet.
Consequences of improper use
Before starting therapy, you must read the instructions for using Reduxin for weight loss. The dosage and duration of therapy is selected only by the attending physician.
An overdose can cause serious complications, which will then be extremely difficult to get rid of. Although Reduxin is modern means, many people who use it complain that side effects appear at the beginning of therapy, which only subside towards the end of the course.
The most common of them are:
- constant headache;
- the occurrence of insomnia;
- increased blood pressure;
- constant dry mouth;
- increased sweating;
- stool disorder.
In most cases, complications develop within the first two weeks. If during this period the patient feels unsatisfactory, it is recommended to tell the doctor about this, who will tell you whether to discontinue the drug.
On a note! Unlike most other similar medications, after discontinuation of Reduxin, withdrawal syndrome does not appear (a person’s appetite does not increase).
Reduxin Light: composition and release form
Unlike regular Reduxin, this product is a dietary supplement. The active component of the drug is linoleic acid. As excipients, the capsules contain tocopherol, gelatin, microcrystalline cellulose and glycerin.
The product is produced exclusively in the form of capsules, which are packaged in plastic jars. Depending on the volume, the package may contain 30, 90 or 120 pills. Many patients are interested in which Reduxin is more effective for weight loss.
Doctors claim that regular Reduxin is more effective, but Reduxin Light has a softer and more delicate effect on the body.
If a woman is not obese, but just wants to slightly adjust her silhouette, preference should be given to the second drug. The risk of side effects and complications in this case will also be minimal.
According to the attached instructions, you need to drink 1-2 capsules before each meal. The maximum permissible daily dose is 6 capsules. With this regimen, you can lose weight with Reduxin in a month. The drug can be used for no more than 2 months.
Method of use and contraindications to therapy
How to drink Reduxin to lose weight, the doctor will tell you after an examination and identification of the general clinical picture. Before using capsules, you must ensure that there are no contraindications, otherwise such therapy should be abandoned.
The product should not be used for the following health problems:
- obesity caused by;
- mental disorders;
- problems with the functioning of the gastrointestinal tract;
- arrhythmia, tachycardia, heart failure;
- severe liver or kidney failure;
- increased activity of the thyroid gland;
- Availability ;
- bearing a child and lactation period;
- age less than 18 years.
If the patient has no contraindications, the product can be used. More often, a single use of the drug per day is prescribed, and the amount of the drug is selected individually for each person. The standard dose is 10 mg per day. If intolerant, it can be reduced to 5 mg.
It is recommended to take the tablet in the morning with plenty of water. It is allowed to use both on an empty stomach and during meals. If, after 3 days after starting treatment, the patient loses less than 2 kg, the dosage is increased to 15 mg. per day. Treatment with the drug should not last more than 2 months, with the exception of special cases.
On a note! To lose weight, one dose will not be enough. The patient will need to reconsider his lifestyle, change his diet and start exercising.
Side effects
Since Reduxin is a fairly powerful drug, its use is not always well tolerated by the body.
Many patients experience the following complications:
- increased heart rate and dilation of peripheral blood vessels;
- loss of appetite, severe nausea;
- exacerbation of hemorrhoids;
- on the part of the nervous system, feelings of anxiety, sudden mood swings, and depression may occur;
- the appearance and pinpoint hemorrhages under the skin;
- Some women experience disruptions to their menstrual cycle while taking Reduxin.
If such complications occur, you need to consult a doctor who will tell you what to do next.
Efficiency mark
Most patients taking this weight loss product are satisfied with it. This is due to the fact that with an integrated approach, the drug really helps to reduce weight and correct the contours of the figure.
There are also negative reviews, but not many of them. Negative opinions are almost always associated with complications that arise during therapy, and not with a lack of effect.
Share your feedback in the comments below the article
Conclusion
Most doctors and nutritionists believe that Reduxin is one of the most effective, but at the same time safe drugs. But before you start taking it, in any case, you need to visit a specialist and draw up an individual application regimen.
In this article you can read the instructions for use of the drug Reduxin. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Reduxin in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Reduxin in the presence of existing structural analogues. Use for the treatment of nutritional obesity and weight loss, including during pregnancy and lactation.
Reduxin- a combined drug for the treatment of obesity, the effect of which is determined by its constituent components. Reduxin (its active ingredient Sibutramine) is a prodrug and exhibits its effect in vivo due to metabolites (primary and secondary amines) that inhibit the reuptake of monoamines (mainly serotonin and norepinephrine). An increase in the content of neurotransmitters in synapses increases the activity of central serotonin 5-HT receptors and adrenergic receptors, which increases the feeling of satiety and reduces the need for food, as well as an increase in thermal production. By indirectly activating beta3-adrenergic receptors, sibutramine acts on brown adipose tissue. A decrease in body weight is accompanied by an increase in the concentration of HDL in the blood serum and a decrease in the amount of triglycerides, total cholesterol, LDL, and uric acid.
Reduxin and its metabolites do not affect the release of monoamines and do not inhibit MAO; have no affinity for a large number neurotransmitter receptors, including serotonin (5-HT1, 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C), adrenergic receptors (beta1, beta2, beta3, alpha1, alpha2), dopamine (D1, D2), muscarinic, histamine (H1), benzodiazepine and NMDA receptors.
Microcrystalline cellulose is an enterosorbent, has sorption properties and a nonspecific detoxification effect. Binds and removes from the body various microorganisms, their metabolic products, toxins of exogenous and endogenous nature, allergens, xenobiotics, as well as an excess of certain metabolic products and metabolites responsible for the development of endogenous toxicosis.
Compound
Reduxin consists of two components:
- sibutramine hydrochloride monohydrate
- microcrystalline cellulose
Pharmacokinetics
After taking the drug orally, sibutramine is quickly absorbed from the gastrointestinal tract, by at least 77%. Active metabolites undergo hydroxylation and conjugation to form inactive metabolites, which are excreted primarily by the kidneys.
Indications
For weight loss in the following conditions:
- nutritional obesity with a body mass index (BMI) of 30 kg/m2 or more;
- nutritional obesity with a BMI of 27 kg/m2 or more in combination with other risk factors caused by excess body weight (type 2 diabetes mellitus/non-insulin dependent/or dyslipoproteinemia).
Release forms
There is no dosage form in the form of tablets for the drug Reduxin. If you've seen a mention of pills somewhere, don't believe them, they're counterfeits that can be dangerous to your health.
Capsules 10 and 15 mg.
Reduxin Light - capsules 625 mg.
Instructions for use
Reduxin is prescribed orally once a day. The dose is set individually, depending on tolerability and clinical effectiveness. The recommended starting dose is 10 mg; in case of poor tolerance, a dose of 5 mg can be taken. Capsules should be taken in the morning, without chewing and with sufficient liquid. The drug can be taken on an empty stomach or combined with meals.
If within 4 weeks from the start of treatment a reduction in body weight of 5% or more is not achieved, then the dose is increased to 15 mg per day. The duration of therapy with Reduxin should not exceed 3 months in patients who do not respond well to therapy (i.e., who fail to reduce weight by 5% of initial body weight within 3 months of treatment). Treatment should not be continued if, with further therapy (after achieving a reduction in body weight), the patient again gains 3 kg or more in body weight.
The total duration of therapy should not exceed 2 years, since there are no data on efficacy and safety for a longer period of taking sibutramine.
Therapy with Reduxin should be carried out by a doctor with practical experience in the treatment of obesity. Taking the drug should be combined with diet and exercise.
Differences Reduxin Light
Unlike the usual Reduxin Light form, it is a biologically active supplement (BAA) and is sold in any pharmacy without a prescription.
Side effect
- dry mouth, insomnia;
- headache, dizziness;
- anxiety;
- paresthesia;
- depression;
- drowsiness;
- emotional lability, anxiety, irritability, nervousness;
- convulsions;
- tachycardia, palpitations;
- increased blood pressure;
- loss of appetite;
- constipation;
- nausea;
- sweating;
- skin itching;
- dysmenorrhea;
- swelling;
- flu-like syndrome;
- bleeding;
- thrombocytopenia.
Most often, side effects occur at the beginning of treatment (in the first 4 weeks). Their severity and frequency weaken over time. Side effects are generally mild and reversible.
Contraindications
- the presence of organic causes of obesity (for example, hypothyroidism);
- serious eating disorders (anorexia nervosa or bulimia nervosa);
- mental illness;
- Gilles de la Tourette syndrome (generalized tics);
- simultaneous use of MAO inhibitors (for example, phentermine, fenfluramine, dexfenfluramine, ethylamphetamine, ephedrine) or their use within 2 weeks before prescribing Reduxin; use of other drugs acting on the central nervous system (for example, antidepressants, antipsychotics); drugs prescribed for sleep disorders containing tryptophan, as well as other centrally acting drugs for weight loss;
- IHD, decompensated chronic heart failure, congenital heart defects, occlusive diseases of peripheral arteries, tachycardia, arrhythmias, cerebrovascular diseases (stroke, transient cerebrovascular accidents);
- uncontrolled arterial hypertension (BP above 145/90 mmHg);
- thyrotoxicosis;
- severe liver dysfunction;
- severe renal dysfunction;
- benign prostatic hyperplasia;
- pheochromocytoma;
- angle-closure glaucoma;
- established drug, drug or alcohol dependence;
- pregnancy;
- lactation (breastfeeding);
- children's and adolescence up to 18 years old;
- old age over 65 years;
- established hypersensitivity to sibutramine or other components of the drug.
Use during pregnancy and breastfeeding
The drug should not be used during pregnancy due to the lack of sufficiently convincing studies on the safety of the effects of sibutramine on the fetus.
Women of childbearing age should use contraception while taking Reduxin.
Reduxin should not be used during breastfeeding.
special instructions
Reduxin should be used only in cases where all non-drug measures for weight loss are ineffective - if the weight loss over 3 months is less than 5 kg.
Treatment with Reduxin should be carried out as part of complex therapy for weight loss under the supervision of a physician with practical experience in the treatment of obesity.
Complex therapy for obesity includes both changes in diet and lifestyle, as well as increased physical activity. An important component of therapy is the creation of prerequisites for permanent changes in eating habits and lifestyle, which are necessary to maintain the achieved weight loss even after drug therapy is discontinued. As part of therapy with Reduxin, patients need to change their lifestyle and habits in such a way as to ensure that the achieved weight loss is maintained after completion of treatment. Patients should be clear that failure to comply with these requirements will lead to repeated weight gain and repeated visits to their doctor.
In patients taking Reduxin, it is necessary to measure blood pressure and heart rate. During the first 2 months of treatment, these parameters should be monitored every 2 weeks and then monthly. In patients with arterial hypertension (whose blood pressure levels are above 145/90 mmHg during antihypertensive therapy), this control should be carried out especially carefully and, if necessary, at shorter intervals. In patients whose blood pressure exceeded 145/90 mmHg twice during repeated measurements. treatment with Reduxin should be suspended.
The interval between taking MAO inhibitors and Reduxin should be at least 2 weeks.
The connection between taking Reduxin and the development of primary pulmonary hypertension has not been established, however, given the well-known risk of drugs in this group, with regular medical monitoring it is necessary to pay special attention to symptoms such as progressive dyspnea (breathing difficulty), chest pain and swelling in the legs.
Impact on the ability to drive vehicles and operate machinery
Taking the drug Reduxin may limit the patient's ability to drive vehicles and operate machinery.
Drug interactions
Inhibitors of microsomal oxidation, incl. inhibitors of cytochrome P450 isoenzyme 3A4 (including ketoconazole, erythromycin, cyclosporine) increase plasma concentrations of sibutramine metabolites with an increase in heart rate and a clinically insignificant increase in the QT interval. Rifampicin, macrolide antibiotics, phenytoin, carbamazepine, phenobarbital and dexamethasone can accelerate the metabolism of sibutramine. The simultaneous use of several drugs that increase the level of serotonin in the blood can lead to the development of a serious interaction. The so-called serotonin syndrome can develop in rare cases when Reduxin is used simultaneously with selective serotonin reuptake inhibitors (drugs for the treatment of depression), with certain drugs for the treatment of migraines (sumatriptan, dihydroergotamine), with potent analgesics (pentazocine, pethidine, fentanyl) or antitussives drugs (dextromethorphan). Sibutramine does not affect the effect of oral contraceptives.
When taking sibutramine and ethanol (alcohol) simultaneously, no increase in negative action ethanol However, alcohol consumption is absolutely not combined with the dietary measures recommended when taking sibutramine.
Analogues of the drug Reduxin
Structural analogues according to active substance:
- Reduxin Light
If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and look at the available analogues for the therapeutic effect.
It is known that an increasing proportion of the world's population has been suffering from obesity in recent decades. It's no secret that the point here is not even about aesthetic shortcomings, but rather about the potential for very serious diseases, such as arterial hypertension, coronary heart disease, myocardial infarction, type 2 diabetes mellitus, infertility, and so on.
Anyone who has ever decided to fight the notorious kilograms knows how difficult it is: grueling diets, severe physical activity, giving up your favorite foods, limiting yourself in almost everything. People are ready to lose weight by any means in order to quickly get rid of fat, which is why many people who want to lose weight are looking for new ways to lose weight. We are talking about taking medications. In the treatment of obesity, drugs of a wide variety of types are used. But reduxin is best known for its combined effect.
About the drug
Reduxin (REDUKSIN) is a domestic drug for weight loss, the main active component of which is sibutramine, a potent substance with a complex effect on the body.
Its first and main effect is to provide an anorexigenic effect, which is based on blocking the reuptake of neurotransmitters in the synapses of the brain, as a result of which a feeling of satiety occurs much earlier than usual.
The second effect is associated with stimulating metabolism. In this case, the body begins to experience a greater need for energy, the consumption of which begins to increase. All this leads to the fact that the absorption of food and the use of nutrients contained in food is much more active.
Reviews from doctors
After examination and observation of patients who took Reduxin, doctors’ reviews can be summarized as follows:
- 98.5% of patients experienced a noticeable decrease in appetite;
- The portions eaten and the patient’s usual daily calorie intake are significantly reduced. On average 2 – 2.5 times;
- in the process of taking the drug, those losing weight develop correct eating behavior;
- this drug for weight loss gives the most stable results, which patients manage to maintain for a long time;
- In general, sibutramine is well tolerated by patients and is not addictive.
Thanks to all this, rapid weight loss is achieved. The patient receives visible motivation.
Vladimir Larionov, nutritionist
I know from practice that Reduxin is excellent in treating obesity when folk remedies for weight loss are already incapable of bringing good results. At the same time, having read only the most general reviews, some women, and often men, begin to drink it on their own. After this, serious side effects occur. I can recommend this drug to combat obesity. But only on condition that a doctor is constantly involved in this process.
To achieve a lasting effect, taking the drug should last at least three months, and its use should be combined with moderate physical activity and a balanced diet.
Positive effects of taking Reduxin
In general, reduxin has established itself as one of the best drugs for the treatment of obesity and weight loss, and there is a feeling that humanity has invented universal anti-obesity pills, taking which you can get rid of terrible problems forever.
Reviews from doctors allow us to mark it as the optimal drug, the use of which does not depend on food intake. It is very convenient when you can take just 1 tablet a day without having to adjust to the need to eat something.
What side effects can reduxin cause?
But like any pharmaceutical drug, reduxin has a number of side effects:
- headache;
- changes in appetite;
- constipation;
- heartburn;
- dry mouth;
- weakness;
- backache;
- nervousness;
- difficulty falling asleep or poor sleep;
- runny nose;
- flu symptoms.
Some side effects may be serious. The following symptoms are not typical, but if any of them are present, you should consult a doctor immediately: rapid heartbeat, chest pain, difficulty breathing, nausea, intense pain in the stomach, vomiting, euphoria, restlessness, anxiety, depression, dizziness, loss of consciousness, confusion, uncoordinated or abnormal movements, muscle stiffness, uncontrollable hand shaking, seizures, trembling, excessive sweating, fever, sore throat, dilated pupils, vision changes, eye pain, rash, redness of the skin, itching, difficulty speaking , breathing or swallowing, hoarseness, swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles.
In addition, reduxin is not compatible with most medications; it puts increased stress on the liver, and can even cause poisoning with regular flu powders containing paracetamol. Remember that taking strong weight loss medications on your own can be dangerous to your health. Therefore, reduxin should be prescribed by a competent doctor after carrying out special diagnostic measures.
