Nise tablets what are they for? Compatibility of Nise gel and polydex. Special instructions for use of Nise

Nise is a popular drug for relieving pain and inflammation. It is available in a variety of dosage forms, which makes use comfortable and suitable for various situations. But the contraindications of the drug must be taken into account - like other non-steroidal anti-inflammatory drugs (NSAIDs), if taken uncontrolled, it can have many unpleasant effects.

The medicine Nise is part of the NSAID group. It is often prescribed for various inflammations in the body, for menstrual pain and headaches. The composition of Nise varies depending on the form of the drug in terms of the inclusion of additional components, but the main active substance one. This is nimesulide, a sulfonanilide derivative, one of the first non-steroidal anti-inflammatory drugs developed.

The form of release of the medicine varies. There are no ampoules for injection in pharmacies - injections with this active substance are not performed. Here are the main types of the product:

Nise tablets contain a dose of 100 mg of nimesulide.
Soluble (dispersible) tablets include 100 mg or 50 mg of nimesulide.
The gel in aluminum tubes (20 g and 50 g) contains a 1% concentration of the active substance.
Nise suspension is based on 50 mg of nimesulide in every 5 ml of solution. Intended for children's use (from 2 years).

To ensure the desired shape and more pleasant taste, the product contains a number of other ingredients. For example, orange, lemon and other flavors, citric acid, sucrose, and maltodextrin are added to the suspension and soluble tablets. These dosage forms are less irritating to the gastrointestinal mucosa.

Nise gel has a transparent structure, slightly yellowish. It contains various preservatives, potassium compounds, water, fragrance, thimerosal, propylene glycol. The composition of Nise in tablet form is represented by a complex set of components - it includes calcium hydrogen phosphate, cellulose, starch, talc, magnesium compounds, silicon, etc. Most manufacturers produce tablets with a score, along which the product can be divided in half (50 mg each).

Like other drugs in the group, this drug has a number of positive effects on the body:

Pain reliever;
Antipyretic;
Anti-inflammatory.

Such wide possibilities are due to the ability to suppress a special enzyme - cyclooxygenase. When it is released, leukotrienes and prostaglandins, which are also called inflammatory mediators, begin to be produced. With their increased production, the inflammatory process in the tissues is maintained, therefore, many toxic substances and cell breakdown products are released into the blood. This leads to swelling, pain, and increased temperature.

After taking Nise, the activity of inflammation quickly decreases, the symptoms subside. The description of the medicine states that its effect is not specific - this means it is effective for any type and location of the inflammatory reaction. In terms of effectiveness, the drug is superior to drugs based on ibuprofen, diclofenac, acetylsalicylic acid, especially in terms of antipyretic action.

Nise ointment (gel) is a local form of the drug and is practically not absorbed into the general bloodstream. Therefore, it has less broad contraindications. Tablets and granules are quickly absorbed, and the maximum concentration in the blood is reached after 1.5 hours. Due to its ability to penetrate into the female reproductive system, into the synovial fluid of blood vessels, the medicine is used in gynecology, traumatology, orthopedics, and surgery.

The main indications will depend on the form of the product. The ointment can only be applied topically, used as prescribed by a doctor (in courses) or independently (one-time, short courses). The main indications for the use of Nise in local form are pain, swelling, redness, swelling, and stiffness. The gel is widely used for muscular-articular syndrome against the following diseases of the musculoskeletal system:

Gouty arthritis, exacerbation of gout;
Radiculitis, sciatica, lumbodynia;
Rheumatism of the joints (rheumatoid arthritis);
Juvenile arthritis;
Infectious joint damage;
Bursitis;
Synovitis;
Tendinitis;
Tenosynovitis;
Psoriatic arthritis;
Osteoarthritis;
Osteochondrosis;
Hernial protrusion of the intervertebral disc;
Disc protrusion;
Arthrosis of intervertebral discs;
Spondylitis;
Ankylosing spondylitis;
Ankylosing spondylitis;
Radicular syndrome in osteochondrosis;
Cervicalgia;
Myalgia.

Nise in local form helps with any injury to bones, soft tissues, joints (as a symptomatic remedy). It reduces pain in the area of bruises and hematomas. You can also use the analgesic properties of the drug against neuralgia of the facial nerve and other localizations.

What do Nise tablets help with? They are recommended for acute pain, difficult to relieve with local remedies, which occurs against the background of sprains, fractures, dislocations, bruises and other injuries. Painkillers are also prescribed for severe pain in the back, neck, knees, other joints, muscle and skeletal system. The drug has proven itself well for headaches, migraines, pain in teeth and jaws. The medicine will help with painful periods, pain due to inflammation in the genital area, kidneys, and bladder.

It should be remembered that Nise does not have a therapeutic effect in most pathologies and does not affect the course of the disease, it only reduces the activity of inflammation. In parallel, pathogenetic therapy must be carried out.

For the drug Nise, the attached instructions for use (in tablet form) must be followed very strictly. You should take the tablets or suspension after meals. For people susceptible to exacerbations of gastritis and peptic ulcers, it is important to take Omez, Omeprazole, Nolpaza or other drugs that reduce acid production in the stomach in advance. The drug should be swallowed in tablets without chewing, with 100-200 ml of water. Soluble tablets should be pre-diluted with the same volume of warm liquid.

The dosage of Nise in tablets (from 12 years of age) is as follows:

For pain, fever, to reduce inflammation in any area of the body - 100 mg twice a day (taken after 12 hours);
For severe pain - 100 mg four times a day (every 6 hours).

Taking more than 400 mg/day can cause an overdose! The duration of therapy is determined only by the doctor. It ranges from 2 days to 2-3 weeks. Children 2-12 years old are given Nise in the form of a suspension. Dose – 3-5 mg/kg body weight per day, divided into 2-3 doses.

Nise gel has the following instructions for use. It is applied to clean, dry skin in a thin layer, evenly. To apply, squeeze out the gel no more than 3 cm (strip). This dose can be used up to 4 times a day. You cannot use the external remedy for more than 10 days without additional consultation with a doctor! When applying more than 50 g of the product to large areas of the skin, there is a high risk of systemic side effects or overdose.

Nise gel has a much smaller list of contraindications than tablets. These include pregnancy, breastfeeding, intolerance to nimesulide, as well as a number of diseases:

Dermatoses, eczema;
Areas of violation of skin integrity;
Infectious skin pathologies covering the painful area.

Long courses are not recommended if you are prone to acute gastritis, recurrent ulcers, organ failure (including cardiac failure), or severe hypertension. Only under the supervision of a physician should the gel be used by asthmatics whose pathology is associated with intolerance to aspirin and other NSAIDs. Children under 12 years old should not use the gel.

Nise tablets, like other oral forms, have more extensive contraindications. In addition to those mentioned above, prohibitions include:

Bleeding from any part of the gastrointestinal tract;
Nasal polyposis;
Vascular bleeding;
Crohn's disease;
Bleeding disorders;
Acute liver pathology;
Addiction;
Alcoholism;
Early period after operations on the heart and blood vessels.

Nise tablets can only be taken after reaching 12 years of age. From 2 years of age it is allowed to use the drug in suspension.

Side effects

The drug often gives various side effects. With excessively long or extensive application, even Nise gel can manifest itself as systemic side effects. These include, first of all, symptoms from the gastrointestinal tract: nausea, pain in the stomach, abdomen, exacerbation of gastritis, increased acidity, diarrhea. In severe cases, taking NSAIDs can even provoke the development of intestinal and stomach ulcers. In some patients, liver function tests increase (drug-induced hepatitis).

Headaches, dizziness, and allergies are also possible as a reaction to treatment with the drug. The hematopoietic system often malfunctions when taking medication - the amount of hemoglobin, leukocytes and granulocytes, and platelets decreases. Typically, such disorders are reversible and disappear after completion of therapy. In people with kidney pathologies or hypersensitivity to nimesulide, hematuria and edema are possible. The appearance of any “side effects” requires discontinuation of therapy!

The cost of 20 tablets with this name is 260 rubles; for the powder for making the suspension you need to pay a price of about 320 rubles. Nise tablets in the amount of 10 pieces have a price of 170 rubles. How much the gel for external application costs depends on the volume - 20 ml - 250 rubles, 50 ml - 360 rubles.

An analogue of the drug with the same active ingredient is Nimesulide-Teva. The medicine Nimesil is also sold in bags of granules for internal use. Nimesulide also contains the following:

Nimulid;
Nimika;
Nemulex;
Nimesan.

Nise's analogs drug group very diverse. These are tablets Amelotex, Diclofenac, Ibuklin, Ketonal Duo, Meloxicam. Analogues of the ointment are external agents Fastum-gel, Bystrumgel, Ketoprofen, Diklak and many others.

Nise (active ingredient nimesulide) – medicinal product anti-inflammatory, antipyretic and analgesic effects. Effectively relieves the symptoms of the disease, but does not affect the root cause of the disease.

Release form

The medicine is produced in the following forms:

In the form of tablets;
In the form of a gel or cream for external use;
In the form of granules and powder for preparing a suspension;
In the form of ampoules for the preparation of solutions for injections;
In the form of candles.

Indications for use

Nise tablets are prescribed for:

Any types of arthritis;
Exacerbation of gout;
Problems with joints;
Spondylitis;
All types of osteochondrosis and radicular syndrome;
Inflammation of ligaments and tendons;
Consequences of operations and injuries;
Neck pain and sprains;
Various pains (headache, toothache, arthralgia);
Low blood pressure.

Suspensions are used:

For the treatment of osteoarthritis;
For severe pain in the back and lower back;
After injuries and dangerous stretch marks;
For toothache;
With algodismenorrhea.

The gel is effective:

For chronic diseases of the musculoskeletal system;
With articular syndrome;
For the treatment of osteochondrosis and arthrosis;
When tendons rupture;
To relieve severe muscle pain;
To relieve inflammation in tissues;
For severe bruises.

Contraindications for use

If you are allergic to the components of the medicine;
Patients with asthma;
For ulcerative formations on the gastric mucosa;
At the time of bleeding;
For inflammation in the intestines;
If the patient has a blood clotting disorder;
With insufficiency in the kidneys and liver;
Patients suffering from alcoholism and drug addiction;
With hyperkalemia;
Pregnant and breastfeeding women.

Nise in gel form can provide negative impact at:

Sinus polyposis;
Ulcer in the stomach;
Dermatosis;
Various lesions on the skin;
Kidney failure in a severe stage.

Use of medication during pregnancy

prohibited for use during pregnancy and breastfeeding. If a doctor prescribed this drug during lactation, the child should be switched to special feeding formulas. Experts advise women to stop using Nise at the stage of pregnancy planning (preferably several months before conceiving a child).

Side effects from taking tablets and Nise suspension

An incorrectly calculated dose of the drug or the patient’s individual intolerance to its components leads to side effects. From the lymphatic system, they manifest themselves as follows:

anemia;
the occurrence of eosinophilia;
thrombocytopenia;
agranulocytosis;
pancytopenia.

External symptoms are expressed in:

profuse rash and severe itching;
hives;
swelling of the skin;
Stevens-Johnson syndrome;
exudative erythema;
Lyell's syndrome.

The nervous system also experiences discomfort. There are:

nausea and vomiting;
constipation;
gastritis;
diarrhea;
bleeding in the stomach;
damage to mucous membranes;
stomatitis;
flatulence.

Among other things, there are:

general malaise of the body;
problems with urination;
dysuria;
bronchial asthma;
tachycardia and increased blood pressure;
loss of vision;
allergy attacks and anaphylactoid reactions.

Side effects from using Nise gel and ointment

In these forms, the drug has its own specific side effects:

itching and rash;
burning sensation on the skin;
irritation;
peeling of the skin;
erythema.

If any side effects from using Nise it is necessary immediately seek advice from a specialist. The doctor will either adjust the dosage of the medication or interrupt the course of treatment.

Basic precautions when taking tablets

In some cases, the use of Nise is prescribed with extreme caution:

For stomach diseases;
With low blood clotting;
Elderly patients;
For liver diseases;
If the patient has abdominal pain and dark urine;
For cardiac disorders;
For kidney problems.

Patients with diabetes are advised to use the drug in suspension form with extreme caution. This is due to the fact that it contains sucrose.

Driving during treatment

When taking painkillers, Nise is better refuse from activities that require increased concentration. For example, from driving a car. Nise in gel form does not inhibit reactions and does not affect the safety of driving.

Nise tablets instructions for use

Nise tablets are taken before meals, washed down with plenty of water. Depending on the age of the patient, the dosage of the drug is as follows:

For adults: no more than 100 mg of the drug per day. In rare cases, doctors allow the dose to be increased to a maximum of 400 mg.
Teenagers over 14 years old: with a body weight of more than 40 kg, the daily dose allowed for an adult is 100 mg. Nise dispersible tablets are dissolved in a teaspoon clean water and taken after meals. In this form, the drug is prescribed to adults and, in extreme cases, to adolescents over 14 years of age.

Gel Nise instructions for use

The medicine in gel form has its own nuances of use:

The gel must be applied to clean, intact skin;
The amount of gel should be moderate (no more than 3 cm according to the special dosage measurement column that comes with the medicine);
The gel is applied to the most painful area of the body and rubbed in with massaging movements;
Gel Nise is used no more than 3 times a day.

Interaction with other drugs

Parallel use of Nise is possible with drugs from these groups:

diuretics;
non-steroidal drugs;
anticoagulants;
lithium preparations;
hypoglycemic drugs.

However, the advisability of such an appointment must be confirmed by a doctor.

Drug overdose

An excess of drug components in the human body can cause complications:

Renal function is impaired;
The mucous membranes of the stomach are irritated;
Breathing problems appear;
Blood pressure increases;
Sharp convulsions are observed.

In such situations, emergency therapy will help. The patient's stomach is washed and given Activated carbon to absorb excess substances in the blood. Until the overdose symptoms completely subside, the patient should be observed by a specialist.

Alcohol compatibility

During treatment with Nise it is worth refuse from drinking alcoholic beverages. Alcohol in combination with the components of the drug leads to irreversible liver damage and poses a threat to the patient’s life.

Storage method and shelf life

Nise tablets are stored in a dark, dry place at a temperature no higher than 25 degrees, no more than 3 years from the date of manufacture indicated on the package.

Gel Nise should not be stored in the refrigerator or frozen. Its storage temperature should not exceed 20 degrees. The shelf life of the medicine in gel form is 2 years from the date of manufacture.

Price

The cost of the drug varies depending on the form of release:

In the form of tablets 100 mg - price for 20 pieces is 180-190 rubles.
In the form of a gel 1% - 160-170 rubles per tube of 20 g.
In the form of a gel - 270-300 rubles per tube of 50 g.

Nise is available with a doctor's prescription.

Analogs

Products with a similar effect to Nise are available from both Russian and foreign manufacturers:

Nimesil;
Nimid;
Nimesulide;
Ibuprofen;
Aponil;
Nimegesic;
Remisid;
Nimika;
Cockstral.

When severe pain appears in the back, lower back, joints, of course, first of all it is necessary to determine the cause of its occurrence. If it is a lumbago from hypothermia, lumbago, or pinched sciatic nerve, intervertebral hernia, etc., you should definitely undergo examination by a neurologist, osteopath, and possibly a gynecologist, urologist, gastroenterologist, since back pain can be not only from spasm of muscles and ligaments , but also for some diseases of internal organs. After a thorough diagnosis, the doctor may prescribe NSAIDs and B vitamins in injections for back pain as part of complex therapy.

Contents [Show]

What injection medications exist to relieve back pain?

NSAIDs

Today, in the treatment of acute pain in the lumbar region and back, medicine finds new principles and algorithms than 50 years ago. The main emphasis in the fight against painful sensations is done to eliminate pain with the help of NSAIDs - non-steroidal anti-inflammatory drugs, which suppress inflammation and reduce pain, as well as muscle blockades.

And after the removal of severe spasms, it is recommended to refuse to immobilize the patient, that is, to conduct physical therapy exercises and perform massage. Most doctors insist that a person during back pain syndromes should not limit his activity as much as possible.

B vitamins

It has also become popular and effective to prescribe combined vitamin complexes, which may have a moderate analgesic effect are vitamins B12, B6, and B1. It is believed that vitamin B12 has a more significant analgesic property. Why these particular vitamins?

Recently, these drugs have begun to be considered in medicine as moderate analgesics, since they are neurotropic - they normalize the innervation of muscles, participate in the transmission of excitation, in the metabolism of mediators, influence metabolism, processes in the nervous system, and promote the restoration of damaged nerves.

Over 90 different studies have proven that the use of B vitamins in clinical practice led to a significant reduction in pain in the acute phases of inflammation in complex treatment. Therefore, they can be used either individually or in the form of complex preparations of B vitamins.

Most complex drugs in this group contain the anesthetic lidocaine, which enhances the local analgesic effect. However, it should be remembered that the use of this group of vitamins makes sense only for acute pain in the back, joints, alcoholic polyneuropathy, myasthenia gravis B12 for 10-14 days, and for chronic recurrent diseases they become ineffective.

Blockade

In cases where painkillers do not help, specialists can offer the patient a method of injections and stretching. It is as follows: after the patient lies on his stomach, the most painful seals or points where the pain is most intense are found in the muscles, and an injection with a novocaine solution is made exactly perpendicularly.

Immediately after the injection, passive stretching of the muscle is performed, after which a hot compress is placed on this place. Then, when the compress is removed, the patient should make active movements, exposing the painful muscle to maximum movement.

The purpose of the novocaine blockade is to “turn off” the nerve. Therefore, the injection points should be as close as possible to the exit points of the nerves, for example, sciatic - at the greater trochanter of the femur, for intercostal neuralgia - in the corresponding intercostal space, for osteochondrosis - at the outer edge of the extensor of the back, etc. It is also advisable to carry out epidural blockades for chronic pain syndrome, for example, for herniated intervertebral discs.

Below is a list of medications prescribed by your doctor according to indications. Only a doctor determines the advisability of using B vitamins, NSAIDs, muscle relaxants, and chondoprotectors. The information below is for informational purposes only; the course of treatment and dosage is determined by a specialist.

When your back or joints hurt, injections of B vitamins should help

B vitamins can also be taken in tablet form, but naturally, intramuscular administration of drugs is considered more effective. Let's consider what drugs of this group exist on the modern pharmaceutical market, their general indications, contraindications, side effects, methods of use and comparative prices in pharmacies:

Milgamma

Milgamma 5 amp. price in pharmacies 220 rubles, 10 amp. 400 rub. 25 amp. 900 rub.

The composition of all these drugs is the same: Lidocaine, Thiamine, Pyridoxine Cyanocobalamin.

Indications: Used for neurological diseases and nervous system disorder syndromes in complex therapy:

Neuritis, facial paresis, trigeminal neuralgia
Back pain caused by diseases of the spine, neurological manifestations (radiculopathy, lumbar ischialgia, musculo-tonic lumbar, cervical, cervical-brachial syndromes, intercostal neuralgia, radicular syndrome due to degenerative changes spine)
night muscle cramps, alcoholic, diabetic polyneuropathy, herpes zoster.

Combilipen

Combilipen 5 amp. 100 -120 RUR, 10 amp. 170-210 rub.
Compligam 160 rub.

Contraindications: Treatment cannot be carried out if:

Pregnancy, lactation
acute, severe types of heart failure
hypersensitivity to components of combined B vitamins
due to lack of research - childhood

Neurobion

3 amp. 220 RUR - Neurobion does not contain Lidocaine in its composition

Side effects: Tachycardia, increased sweating, rarely - allergic reactions - rash, itching, urticaria, skin reactions, difficulty breathing, anaphylactic shock. In case of overdose - nausea, vomiting, dizziness, tachycardia.

Trigamma

5 amp. about 100 rub.

Application: All of the listed injections for back pain are administered deeply intramuscularly, 2 ml 1 time per day for 5-10 days, then you should switch to 2-3 times per week for 14-21 days. or taking vitamins orally.

Efficacy, contraindications and side effects of NSAIDs

Painkillers, of course, are used only as symptomatic therapy; they help eliminate pain in the joints and back, but do not eliminate the cause of its occurrence; in addition, 50% of patients may experience various side effects.

In more than 50 studies aimed at identifying the best pain reliever, researchers found that not a single NSAID drug was more effective than other pain relievers, and some of them are very expensive drugs. The only thing to pay attention to when choosing is that some generics (Russian diclofenac, for example) are significantly inferior in effectiveness to original drugs (European Diclofenac).

Also, these studies were aimed at identifying a drug with the least side effects. As a result, it was found that Ibuprofen is the least toxic of all NSAIDs.

The manufacturers of the new Cox-2 inhibitor, Celebrex, claimed that it had the least side effects, but studies did not find convincing evidence of this fact.

Therefore, when choosing a non-steroidal anti-inflammatory drug, you should remember that they have almost the same anesthetic properties, the same side effects, but different frequency, intensity, severity of side effects, harmful effects, and, not least important, different prices. For example, Meloxicam has less effect on the stomach and intestines than aceclofenac (Aertal). Indomethacin gives a pronounced analgesic effect, but destroys cartilage with prolonged use and is now used less and less.

Moreover, doubling the dose does not reduce the intensity of pain, and in the case when one non-steroidal drug does not help (if it is not a fake), replacing it with another does not make sense. Moreover, based on research, we can also conclude that they are not much more effective than regular paracetamol. You can learn more about all ointments for back pain from our article.

Choice of pain medications

For chronic pain, before prescribing an anesthetic, the doctor determines the causes and nature of chronic pain - referred, neuropathic or central, and prescribes appropriate treatment.

If the pain is acute, then the doctor determines the risk of side effects on the gastrointestinal tract, cardiovascular complications, if the risks are not great, and:

no dyspepsia - then any NSAID
If you have dyspepsia, it is better to use ibuprofen (or diclofenac, naproxen), nimesulide (or miloxicam)

If the risk of cardiovascular complications is high, then NSAIDs should be avoided and Paracetamol and opioids should be used. With a moderate risk, it is possible to prescribe nimesulide, subject to adequate correction of blood pressure (amlodipine, see drugs for lowering blood pressure).

If the risk of gastrointestinal bleeding is high, NSAIDs + definitely proton pump inhibitors (omeprazole). It is understood that taking NSAIDs in itself is a sufficient risk even with a single dose, so the standard is that all NSAIDs are taken in combination with proton pump blockers, regardless of the risks of gastroduodenal bleeding.

When combining the risks of gastrointestinal side effects and cardiovascular complications - Nimesulide + acetylsalicylic acid + omeprazole.

If the pain subsides within 5-7 days, then continue treatment until it is completely relieved.
If sharp pain does not subside within a week, then muscle relaxants and local anesthetics are prescribed. Local administration of corticosteroids is possible if the diagnosis of tuberculosis of the joints or spine is excluded. If the pain is very severe and there is no effect from painkillers, the infectious nature of the pain should be excluded (tuberculosis pathology - consultation and examination at an anti-tuberculosis dispensary), joint pain due to gonorrhea, syphilis or other infection.

See How to give an intramuscular injection yourself and Ointments for back pain.

Review of painkillers in injections

All known NSAIDs for injection, with their general contraindications and side effects, and average prices in pharmacies are presented in the table:

Meloxicam

Movalis(3 amp. 530 rub.) Amelotex(3 amps - 280 rub.) Arthrozan(3 amp. 190 rub.)

Indications for the use of NSAIDs: Symptomatic treatment of ankylosing spondylitis, osteoarthritis, rheumatoid arthritis, elimination of pain - musculoskeletal, back pain of any etiology, postoperative and other pain.

Ketoprofen

Artrosilene(6 amp. 170 rub.) Ketonal(10 amp. 200 rub.) Flamax(5 amps 110 rubles). Flexen(6 amp. 280 rub.)

Contraindications: Hypersensitivity to any component of the drug, heart failure, pregnancy and lactation, severe liver or kidney failure, aspirin-induced bronchial asthma, children under 16-18 years of age, inflammatory bowel diseases, exacerbations of gastric ulcers, gastrointestinal bleeding. Cerebrovascular diseases, ischemic disease heart disease, any severe diseases of the cardiovascular system, concomitant use of antiplatelet agents (clopidogrel, acetylsalicylic acid) prednisolone, liver dysfunction, severe somatic diseases.

With caution: gastrointestinal diseases, Helicobacter pylori infection, edema, fluid retention, diabetes mellitus, long-term use of NSAIDs.

Ketorolac

Ketorol(10 amp. 130-150 rub.), Ketanov(10 amp. 100 rub.) Ketorolac(10 amps 70-90 rub.)

Application: The solution for injections for back pain should be administered deeply intramuscularly in a dosage selected by the doctor depending on the age of the patient and the intensity of the pain. Up to 65 years of age, a single dose of 10-30 mg is prescribed. IM every 4-6 hours. For persons with impaired renal function or over 65 years of age, a dose of 10-15 mg IM once or every 4-6 hours. The maximum daily dose should not be more than 60-90 mg. and the duration of therapy is no more than 5 days.

Diclofenac

Diclofenac(5 amp. 40 rub.) Voltaren(5 amp. 270 rub.) Naklofen(5 amp. 50 rub.), Ortofen(10 amp. 40 rub.)

Side effects: Digestive system: often - diarrhea, gastralgia, constipation, vomiting, nausea, heartburn, hepatitis, acute pancreatitis.
Urinary system: frequent urination, nephritis, edema, acute renal failure.
Respiratory system: shortness of breath, laryngeal edema, allergic rhinitis, difficulty breathing.
CNS: dizziness, headache, drowsiness, hyperactivity, psychosis, hearing loss, depression, blurred vision.
CVS: fainting, increased blood pressure, pulmonary edema.
Hematopoietic organs: eosinophilia, anemia, leukopenia.
Blood clotting: rectal, nasal, gastric bleeding, from a postoperative wound.
Dermatological manifestations: urticaria, skin rash, skin peeling, Lyell's syndrome, Stevens-Johnson syndrome.
Allergic reactions: swelling of the eyelids, wheezing, shortness of breath, change in facial skin color, itching of the skin, rash, heaviness in the chest.
Other: often - weight gain, swelling of the ankles, face, fingers, legs, increased sweating.

Lornoxicam

Xefocam(5 amp. 700-720 rub.)
Tenoxicam
Texamen 1 bottle 200 rub.

Overdose: vomiting, nausea, abdominal pain, peptic ulcers, metabolic acidosis, renal dysfunction.

Interaction: Simultaneous use of NSAIDs with acetylsalicylic acid or other non-steroidal painkillers, as well as corticosteroids, calcium supplements, ethanol, can lead to gastrointestinal bleeding and the formation of gastrointestinal ulcers. Concomitant use with paracetamol increases the risk of nephrotoxicity.

Painkillers in tablets

When your back hurts badly, your doctor may prescribe anti-inflammatory, painkillers in tablets; previously it was believed that oral administration slows down the onset of action, reduces effectiveness and leads to more severe side effects from the gastrointestinal tract. Today it is believed that intramuscular administration and oral administration provide the same bioavailability of the drug. Side effects from the gastrointestinal tract are realized through the suppression of the arachidonic acid system, that is, not through direct contact with the mucous membrane, but after absorption into the blood. Therefore, the side effects are almost the same when taken orally and when injected.

Basic NSAIDs in tablets

Celebrex (active ingredient celecoxib 10 pcs. 400-420 rubles)
Arcoxia (active ingredient etoricoxib 7 pcs. 520 -600 RUR)
Texamen (active ingredient tenoxicam 10 pcs. 200-250 rubles)
Nise, Nimulid, Nimika (active ingredient nimesulide price 20 pcs. 80-140 rubles)
Nalgesin (active ingredient naprxen 10 pcs. 110-130 rubles)
Movalis, Arthrozan, Meloxicam (substance Meloxicam price 20 tablets 40 rubles, Movalis 20 tablets 250 rubles)
Ketanov, Ketarol, Ketorolac (substance Ketorolac price 20 tablets 40-60 rub.)
Naproxen, Nalgesin (substance Naproxen, 120-260 rubles)
Artrosilene, Bystrumkaps, Ketonal, Flexen (substance ketoprofen 20 pcs. 150 rub., Bysrumkaps 10 pcs. 250-270 rub., Flexen 30 pcs. 170 rub.)
Burana, Nurofen, Faspik, Ibuprofen (substance Ibuprofen price 20 pcs. 15 rubles, Nurofen 12 pcs. 110 rubles, Faspik 6 pcs. 100 rubles, Burana 10 pcs. 80 rubles)
Voltaren, Diclak, Naklofen, Ortofen, (substance Diclofenac price 20 pcs. 40 rub., Voltaren 20 pcs. 200 rub., Ortofen 30 pcs. 20 rub., Diclofen 10 pcs. 70-100 rub.)
Aertal 20 tab. 400 rub. - active substance Aceclofenac.
Xefocam 10 pcs. 130-200 rub. - Lornoxicam.

Combined painkillers

Dolaren, Panoxen (20 pcs. 120 rubles) - diclofenac + paracetamol.

Neurodiclovit (30 pcs. 300 rubles) - diclofenac + B vitamins.
Next (RUB 120-170) - paracetamol and ibuprofen.

Muscle relaxants

Most of the pain is based on muscle spasm, which itself tightens the nerve root and causes secondary radicular syndrome, so in many cases muscle relaxants are prescribed as an anesthetic:

Tolperisone - peripheral action, Mydocalm (instructions for use, tablets, injections 30 tablets of 50 and 150 mg 300-400 rubles), Tolperisone 30 pcs. 150-200 rub.
Hydroxyzine - central with inhibition of the central nervous system, suitable for severe pain, Atarax 25 pcs. 300 RUR, Hydroxyzine 25 pcs. 200 rub.
Baclofen is also centrally acting, Baklosan.
Tizanidine - central action, Sirdalud (2 mg. 30 pcs. 230 rub., 4 mg. 30 pcs. 330 rub.), Tizanil (2 mg. 30 pcs. 170 rub., 4 mg. 30 pcs. 250 rub.), Tizalud (2 mg. 30 pcs. . 140 rubles), Tizanidine 4 mg. 30 pcs. 150-200 rub.

Chondoprotectors

Chondroitin sulfate

Mucosat(5 amps 250-500 rubles), Chondrogard(10 amp. 600 rub.), Chondrolone(10 amp. 800-1100 rubles), Artradol(10 amp. 700 rub.)

Chondroitin sulfate - this drug is an anti-inflammatory drug, which is prescribed for the treatment of diseases of the joints and spine. It slows down bone tissue resorption, improves calcium-phosphorus metabolism in cartilage tissue, stops the destruction of connective and cartilaginous tissue, and accelerates recovery processes. Reduces pain and increases mobility of the spine and joints. It is structurally similar to heparin, and therefore prevents the formation of blood clots in the subchondral and synovial beds.

Alflutop

Alflutop (10 amp. 1400-1500 rub.)

This is a modern drug, which is a concentrate from small sea fish that regulates the metabolism of cartilage tissue. The composition of the bioactive concentrate includes amino acids, potassium, sodium, copper, iron, calcium and zinc ions, as well as mucopolysaccharides and peptides. This remedy stimulates the processes of restoration of cartilage tissue, inhibits the destruction of the structures of osteochondral tissues, which provides a moderate analgesic effect.

The drug is prescribed only to adults with osteochondrosis or polyosteoarthrosis; it should be administered intramuscularly at a dose of 1 ml/day for 20 days. If large joints are affected, then it is possible to administer the drug into the joint once every 3-4 days, 1-2 ml, in a course of 5-6 injections.

Video on how to give an intramuscular injection.

Video on how to quickly relieve back pain with exercises.

In this article you can read the instructions for use of the drug Nise. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Nise in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Nise in the presence of existing structural analogues. Use for the treatment of pain and inflammation in joints and muscles in adults, children, as well as during pregnancy and breastfeeding.

Nise- non-steroidal anti-inflammatory drug. Selective inhibitor of COX-2 - an enzyme involved in the synthesis of prostaglandins - mediators of edema, inflammation and pain. The drug has anti-inflammatory, analgesic and antipyretic effects.

Reversibly inhibits the formation of prostaglandin E2, both at the site of inflammation and in the ascending pathways of the nociceptive system, including the pathways of pain impulses in the spinal cord.

Reduces the concentration of short-lived prostaglandin H2, from which prostaglandin E2 is formed under the action of prostaglandin isomerase. A decrease in the concentration of prostaglandin E2 leads to a decrease in the degree of activation of EP-type prostanoid receptors, which is expressed in analgesic and anti-inflammatory effects.

It has a slight effect on COX-1 and practically does not interfere with the formation of prostaglandin E2 from arachidonic acid under physiological conditions, thereby reducing the number of side effects of the drug.

Nise suppresses platelet aggregation by inhibiting the synthesis of endoperoxides and thromboxane A2, and inhibits the synthesis of platelet aggregation factor. Suppresses the release of histamine and also reduces the degree of bronchospasm caused by exposure to histamine and acetaldehyde.

It has been shown that nimesulide (the active ingredient of the drug Nise) is able to suppress the synthesis of interleukin-6 and urokinase, thereby preventing the destruction of cartilage tissue. Inhibits the synthesis of metalloproteases (elastase, collagenase), preventing the destruction of proteoglycans and collagen of cartilage tissue.

It has antioxidant properties and inhibits the formation of toxic oxygen breakdown products by reducing the activity of myeloperoxidase. Interacts with glucocorticoid receptors, activating them through phosphorylation, which also enhances the anti-inflammatory effect of the drug.

When applied topically, it causes a weakening or disappearance of pain at the site of application of the gel, incl. pain in the joints at rest and during movement, reduces morning stiffness and swelling of the joints. Helps increase range of motion.

Pharmacokinetics

After oral administration, Nise is well absorbed from the gastrointestinal tract. Eating reduces the rate of absorption without affecting its extent. Penetrates into the tissues of the female genital organs, where after a single dose the concentration of nimesulide is about 40% of the concentration in plasma. Penetrates well into the acidic environment of the inflammation site (40%) and synovial fluid (43%). Easily penetrates histo-hematological barriers. The metabolite is excreted by the kidneys (65%) and bile (35%).

Indications

rheumatoid arthritis;
articular syndrome with rheumatism and exacerbation of gout;
psoriatic arthritis;
ankylosing spondylitis;
osteochondrosis with radicular syndrome;
radiculitis;
sciatica;
lumbago;
osteoarthritis;
arthritis of various etiologies;
arthralgia;
myalgia of rheumatic and non-rheumatic origin;
inflammation of ligaments, tendons, bursitis;
post-traumatic inflammation of soft tissues and the musculoskeletal system (damage and rupture of ligaments, bruises);
pain syndrome of various origins (including in the postoperative period, with injuries, algodismenorrhea, toothache, headache);
fever of various origins (including with infectious inflammatory diseases).

Release forms

Tablets 100 mg.

Dispersible tablets 50 mg (can be used to prepare a suspension or syrup by dissolving in water, this form convenient for use in children).

Gel for external use 1%.

Instructions for use and dosage

Pills

Adults are prescribed 100 mg orally 2 times a day. The maximum daily dose is 400 mg.

It is preferable to take the drug in the form of a suspension before meals, but if you feel discomfort in the stomach, you can take it at the end or after a meal.

The drug in the form of dispersible tablets should be taken at the end or after meals. Before taking, 1 tablet is dissolved in 5 ml (1 teaspoon) of water.

For children over 2 years of age, the drug is prescribed in the form of a suspension, for children over 3 years of age - in the form of dispersible tablets or suspensions, for children over 12 years of age, the drug can be prescribed in the form of tablets (100 mg 2 times a day). The recommended dose is 3-5 mg/kg body weight 2-3 times a day. The maximum dose is 5 mg/kg per day in 2-3 divided doses. For adolescents weighing more than 40 kg, the drug is prescribed 100 mg 2 times a day.

The maximum dose is 5 mg/kg body weight per day. The duration of use of the drug is 10 days.

Before using the gel, wash and dry the skin surface. Apply a strip of gel approximately 3 cm long in an even thin layer, without rubbing, to the area of maximum pain 3-4 times a day.

The amount of gel and the frequency of its use (no more than 4 times a day) varies depending on the size of the skin area being treated and the patient’s reaction.

The maximum dose is 5 mg/kg per day (30 g per day). The duration of use of the drug is no more than 10 days without consulting a doctor.

Side effect

heartburn;
nausea, vomiting;
pain in the stomach;
diarrhea;
erosive and ulcerative lesions of the gastrointestinal tract;
headache;
dizziness;
thrombocytopenia, leukopenia, anemia, agranulocytosis;
skin rash;
anaphylactic shock;
bronchospasm;
fluid retention;
prolongation of bleeding time;
hematuria (blood in the urine);
when applying the gel - itching, urticaria, peeling, transient change in skin color (does not require discontinuation of the drug).

Contraindications

erosive and ulcerative lesions of the gastrointestinal tract in the acute phase;
bleeding from the gastrointestinal tract;
"aspirin triad";
liver dysfunction;

severe renal failure (CK

Nise is a non-narcotic

anesthetic And

antipyretic drug from the group of non-steroidal anti-inflammatory drugs (NSAIDs). Nise is used as a symptomatic drug as part of complex therapy for various conditions and diseases accompanied by elevated temperature body, pain and inflammation. The main areas of application of Nise are the treatment of osteoarthritis and

osteoarthritis

As well as relieving pain of various etiologies and localizations (for example, injuries, toothache, menstrual pain, diseases of the ear, throat, nose, etc.) and reducing body temperature during infections.

Names, varieties and forms of release

Currently, Nise is available in the following dosage forms:

Tablets for oral administration;
Dispersible tablets (soluble in a small amount of water) for oral administration;
Suspension for oral administration;
Gel for external use.

These dosage forms are conventionally considered varieties of the drug Nise. Of course, it is correct to classify the listed drug variants as different dosage forms, but for everyday use the term “varieties” is quite suitable, provided that all participants in the discussion mean the same thing by it.

Tablets for oral administration are simply called tablets or “Nise 100”, and various terms are often used to refer to the suspension, such as syrup, solution and others, which are united by the fact that they imply a liquid dosage form intended for oral administration. The suspension is also called “Nise for children”, since this particular form of the drug is approved for use in children from 2 years of age. Dispersible tablets are sometimes called soluble tablets because they are intended to be taken orally after first dissolving in a small amount of water. These tablets differ from the usual ones in a lower dosage of the active substance, as well as a minimal risk of irritation of the gastric mucosa.

Gel for external use is often mistakenly called ointment. However, since Nise is not available in this dosage form, when people say “Nise ointment,” they mean the gel.

Nise - composition

As an active substance, all dosage forms of Nise include

nimesulide in the following different dosages:

Tablets for oral administration – 100 mg of nimesulide per tablet;
Dispersible tablets – 50 mg of nimesulide per tablet;
Suspension – 50 mg of nimesulide per 5 ml of solution;
Gel – 1% (10 mg nimesulide per 1 g).

Excipients of all dosage forms of Nise are shown in the table.

Auxiliary components of Nise tablets	Auxiliary components of Nise dispersible tablets	Auxiliary components of Nise suspension	Auxiliary components of Nise gel
Microcrystalline cellulose		Sucrose	Methyl salicylate
Corn starch		Sorbitol	Diaethyl phthalate
Magnesium stearate		Methylparaben	Propylene glycol
Talc		Propylparaben	Sodium benzoate
Colloidal silicon anhydrate	Pineapple flavor	Pineapple flavor	Diethylene glycol monoethyl ether
Sodium glycogen glycollate	Sodium carboxymethyl starch	Quinoline yellow dye	Polyoxyl 40 from castor oil
Calcium hydrogen phosphate	Calcium phosphate	Xanthan gum	Carbomer 940
	Silica	Polysorbate 80	Disodium edetate
	Aspartame	Lemon acid	Water
		Glycerol	Butylated hydroxytoluene
		Water	Capsaicin
			Menthol
			Trometamol

Therapeutic effect

Nise is a drug from the group of non-steroidal

anti-inflammatory drugs(NSAIDs) and has three main therapeutic effects:

Analgesic effect (analgesic);
Antipyretic effect (reduces body temperature);
Anti-inflammatory effect.

All three therapeutic effects are due to the ability of the active substance Nise to block the work cyclooxygenase– an enzyme that synthesizes prostaglandins and leukotrienes. Prostaglandins and leukotrienes are substances that activate and maintain the inflammatory process, causing tissue damage, swelling, pain and redness. In turn, inflammation provokes cell death and the formation of large amounts of toxic substances that enter the systemic bloodstream and provoke an increase in body temperature.

Nise, by blocking the work of cyclooxygenase, prevents the formation of leukotrienes and prostaglandins, which, in turn, stops the active course of the inflammatory process. Since the inflammatory process is minimized, the pain, heat, swelling and redness associated with it are relieved. The functioning of the affected organ is also facilitated.

Since Nise has a nonspecific effect, it is capable of providing a therapeutic effect in the inflammatory process, regardless of the location and nature of the cause that caused it. That is why Nise is able to relieve pain during menstruation, joint diseases, injuries, neuralgia, headaches and toothache etc. The drug also perfectly reduces body temperature during viral or bacterial infection, and also reduces the severity of any inflammatory process, regardless of what exactly it is caused by (for example, infection, autoimmune disease, injury, etc.).

In terms of the severity of the anti-inflammatory effect, Nise is superior to Indomethacin, Diclofenac, Ibuprofen and Piroxicam. The analgesic effect of Nise is the same as that of Ibuprofen, but less pronounced compared to Indomethacin. The antipyretic effect of Nise is more powerful than that of Indomethacin, Ibuprofen, Aspirin and Paracetamol.

Since Nise can exert its effects locally and systemically, it is used in various dosage forms depending on the location of the inflammatory process and pain. For example, when pain and inflammation are localized in internal organs and mucous membranes, it is necessary to take Nise orally so that the drug can reach all affected cells and tissues through the bloodstream. And if the pain is localized in the muscles or skin, you can not take Nise orally, but apply it externally, directly to the affected area, so that the active substances penetrate to the source of inflammation through the skin structures. Often, to enhance the therapeutic effect, the drug is simultaneously taken orally and applied externally, especially for chronic joint diseases.

In addition to the antipyretic, anti-inflammatory and analgesic effects, Nise has a number of other, less significant and less pronounced effects. Thus, the drug reduces the ability of platelets to stick together (aggregate) and form blood clots by suppressing platelet activity factor.

Nise - indications for use

Let's consider the indications for the use of forms for oral and external use in children and adults.

Tablets, dispersible tablets and Nise suspension

All dosage forms of Nise for oral administration are indicated for use in adults with the following diseases or conditions:

Rheumatoid arthritis;
Joint damage due to rheumatism;
Periods of exacerbation of gout;
Psoriatic arthritis;
Ankylosing spondylitis;
Osteochondrosis;
Radiculitis;
Sciatica;
Lumbago;
Osteoarthritis;
Arthritis of any cause;
Joint pain (arthralgia);
Muscle pain (myalgia);
Inflammation of ligaments and tendons (tendinitis, tendovaginitis, etc.);
Bursitis;
Traumatic inflammation of the soft tissues of the musculoskeletal system (for example, after bruises, ruptures and sprains, etc.);
Pain of various origins and localization (menstrual, dental, joint, headache, pain after surgery, with gynecological and ENT diseases, etc.);
Increased body temperature of any origin.

Nise suspension is indicated for use in children with the following diseases or conditions:

Increased body temperature due to any disease, including after vaccination;
Inflammatory process of the ENT organs and respiratory tract during viral or bacterial infections;
Relief of pain after operations, injuries, soft tissue injuries, etc.

It should be remembered that in children and adults Nise is a symptomatic remedy that does not cure the disease, but can only relieve pain, relieve fever and reduce inflammation, thereby easing and improving the general condition of a person. Therefore, it should always be used in combination with other medications, the effects of which are aimed at curing pathology or achieving remission.

Nise gel (ointment)

The gel is used externally in adults and children over 7 years of age with the following diseases or conditions:

Inflammatory or degenerative diseases of bones, joints, ligaments, muscles and tendons, such as gout, rheumatism, arthritis, osteoarthritis, osteochondrosis, radiculitis, lumbago, bursitis, tendinitis, sciatica, etc.;
Muscle pain of any origin;
Traumatic inflammation of the musculoskeletal system (for example, bruises, tears or sprains of muscles, ligaments, etc.).

The gel, like the oral forms, is intended exclusively for symptomatic therapy, that is, relieving pain, fever and reducing inflammation. The gel will not cure a torn ligament, but will only relieve the symptoms of this condition. Therefore, in combination with Nise gel, it is necessary to use drugs or manipulations whose action is aimed at curing the disease.

Instructions for use

Let's consider the rules for using different dosage forms of Nise separately to avoid confusion.

Nise tablets - instructions for use

The tablets should be taken immediately after meals. The tablet is swallowed whole, without biting, chewing or crushing in any other way, but with a small amount of water (100 - 200 ml). It is not recommended to use Nise tablets before meals, as this may cause irritation or discomfort from the stomach.

Nise tablets can be given to children from 12 years of age.

Nise is given to children over 12 years of age in the same dosages as adults. Elderly people over the age of 65 should also take Nise in standard, unreduced dosages. In case of renal failure with creatinine clearance determined by the Rehberg test of at least 30 ml/min, there is also no need to reduce the dosage of the drug. If creatinine clearance is below 30 ml/min, then Nise cannot be used in any dosage.

To relieve pain, relieve fever or reduce the severity of inflammation, it is recommended to take Nise 1 tablet (100 mg) twice a day. It is advisable to take the tablets at regular intervals, for example every 12 hours. If necessary, you can increase the number of tablets to 4 tablets per day, which can be taken at intervals of at least 6 hours. The maximum permissible daily dosage of Nise is 400 mg, exceeding which can cause an overdose.

The duration of taking Nise is determined by the speed of healing and reduction in the severity of painful symptoms. That is, in each specific case, the duration of the course of therapy is determined individually and can range from several days to several weeks.

Instructions for use of Nise dispersible tablets

Dispersible tablets must be taken either with or immediately after a meal. It is not recommended to take the drug in this form before meals, since there is a high risk of developing side effects from the digestive tract.

Before taking, one tablet is dissolved in a teaspoon of water. If you need to take two tablets at once, it is optimal to dissolve them both in a tablespoon of water. In general, to calculate the required amount of water, you can use the following ratio - one tablet per 5 ml of water (1 teaspoon).

Dissolved tablets are taken without additional water or any other drinks. If a person has a desire to wash away the feeling and taste of tablets from the oral mucosa, then they can take a large sip of clean water.

Dispersible tablets can be given to children from three years of age.

To relieve pain, fever and inflammation in various diseases, adults and adolescents over 12 years of age should take Nise 100 mg (2 dispersible tablets) twice a day. If necessary, you can increase the frequency of taking tablets up to 4 times a day, keeping at least 6-hour intervals between them. The maximum permissible daily dosage of Nise for adults and children over 12 years of age is 400 mg.

In elderly people over 65 years of age and with renal failure with a creatinine clearance of at least 30 ml/min, Nise is used in normal dosages, which do not need to be reduced. In case of renal failure with creatinine clearance below 30 ml/min, Nise cannot be used in principle.

For children aged 3 – 12 years, the daily dosage of Nise is calculated individually according to body weight, based on the ratio of 3 – 5 mg per 1 kg of weight. For example, a child weighing 20 kg should take Nise at a dosage of 3 * 20 = 60 mg and 5 * 20 = 120 mg, that is, 60 – 120 mg per day. The daily dosage calculated in this way is divided into 2 - 3 equal parts for administration 2 - 3 times a day at approximately equal intervals. The maximum permissible daily dosage of Nise is 5 mg per 1 kg of child’s body weight. If the child weighs more than 40 kg, but is under 12 years old, then he is given Nise in an adult dosage of 100 mg twice a day.

The duration of use of Nise is determined individually depending on the speed of disappearance of symptoms.

Instructions for use of Nise suspension

Before use, shake the bottle with the suspension so that its contents become homogeneous, then pour the required amount into a measuring cup or syringe and drink. If necessary, you can wash down the suspension with a small amount of water.

Nise in the form of a suspension can be used for children from two months in the following dosages:

Children aged 2 months - 2 years - the dosage of the suspension is calculated individually according to body weight, based on the ratio of 1.5 mg per 1 kg of weight. That is, a child weighing 10 kg needs 1.5 * 10 = 15 mg of Nise per day. The calculated daily amount of the drug is divided into 2 - 3 equal parts and given to the child 2 - 3 times a day. In our example, 15 mg/3 = 5 mg, that is, the child needs to be given a Nise suspension of 5 mg (which corresponds to 0.5 ml or 13 drops) three times a day;
Children aged 2 – 5 years – take 2.5 ml of suspension 2 – 3 times a day;
Children 5 – 12 years old – take 5 ml of suspension 2 – 3 times a day;
Children over 12 years old - take the drug in an adult dosage in any dosage form, that is, 100 mg 2 times a day, which corresponds to 10 ml of suspension, 1 regular tablet or 2 dispersible tablets.

The suspension can be used not only for children, but also for adults who, for some reason, cannot or do not want to take tablets. In all cases, for a person of any age there are no restrictions on the use of the Nise suspension; it is only necessary to dose the drug correctly. The only category of people who are undesirable to take Nise in the form of a suspension due to the presence of sucrose in it are patients with diabetes mellitus.

The duration of taking Nise suspension is different and depends on the speed of normalization of the person’s condition and the disappearance of symptoms. In acute conditions, it is recommended to use Nise for no more than 5–10 days.

Gel (ointment) Nise - instructions for use

The gel is applied to previously washed and dried areas of the skin in the area of direct projection of pain and inflammation. If

not open, then wash the skin with warm water and soap and dry it well with a soft towel. If there is an open wound on the skin, symptoms

dermatitis

or any damage, then Nise gel cannot be applied.

For a one-time application, squeeze out approximately 3 cm of gel from the tube and, without rubbing, distribute it evenly over the affected surface. Then leave for 1 - 2 minutes so that the composition is absorbed into the skin. After this, you can apply a regular gauze bandage to the damaged area or leave it uncovered. Airtight dressings should not be applied over the gel.

The gel is applied to the skin 3 – 4 times a day. It is not recommended to apply the gel more than 4 times a day, as this may cause the development of side effects. The maximum allowable amount of gel that can be used during the day is 30 g, which corresponds to 1.5 tubes of 20 g.

The duration of use of the gel is determined individually depending on the speed of disappearance of unpleasant symptoms. It is not recommended to use Nise gel for more than 10 days in a row without consulting a doctor.

When rubbing the gel into the surface of the skin, a burn may occur, which will go away on its own within a few days. If irritation appears in the area where the gel is applied, you should stop using Nise.

Capsaicin, which is part of the gel, can provoke a burning sensation and redness of the skin in the area of application. In rare cases, the burning sensation does not disappear, but turns into increased sensitivity this area of skin. These effects are a normal skin reaction to the gel and do not require discontinuation of the drug.

When using the gel, it is necessary to avoid contact with the eyes, as well as the mucous membranes of the nose, mouth and other organs. After using the drug, close the tube tightly and wash your hands with soap.

special instructions

Nise in the form of tablets, dispersible tablets and suspension should be used with caution in people suffering from

eye diseases

Kidney and liver. If creatinine clearance due to renal failure is less than 30 ml/min, then Nise cannot be used. In other cases, with renal failure, the drug is allowed for use, but with caution and under the close supervision of a physician. During the entire period of therapy, if it lasts more than a week, liver function should be monitored and

If there is a deterioration in the condition or function of the kidneys or liver, then Nise should be discontinued and any drugs containing nimesulide should not be used in the future.

Nise should also be used with caution by people suffering from cardiovascular diseases, dehydration, asthenia, metabolic disorders and diseases of the digestive tract.

Since Nise can reduce blood clotting, it should be used with caution by people prone to bleeding, taking anticoagulants and suffering from hemorrhagic diathesis. If these conditions are present, blood clotting parameters (platelet count, fibrinogen, APTT, PTI, INR, TV, etc.) should be monitored during the entire course of using Nise.

In order to reduce the risk of side effects, it is necessary to use Nise in the minimum effective dosage. If a person’s condition does not improve within 2–3 days while using Nise, then you should stop taking the drug and consult a doctor.

If, while taking Nise tablets or suspension, a person experiences nausea, anorexia, vomiting, abdominal pain, dark urine, yellowing of the skin, increased activity of AST and ALT, as well as fatigue, then you should immediately stop using the drug and consult a doctor, since these symptoms indicate the development of liver damage. In the future, a person who experiences similar symptoms should not take Nise or any other medications containing nimesulide.

Impact on the ability to operate machinery

Gel Nise does not impair the ability to operate machinery. Nise tablets and suspension can provoke

dizziness

drowsiness

Therefore, while taking these dosage forms of the drug, you should refrain from any activities that require a high speed of reactions and concentration.

Overdose

The gel, as a rule, does not cause an overdose. However, when applying more than 50 g of gel at a time, this is possible. When using tablets and suspensions, an overdose is also possible, and it is manifested by the following symptoms:

Apathy;
Drowsiness;
Nausea;
Vomit;
Increased pressure;
Impaired kidney function (swelling, urinary retention, increased concentration of urea, creatinine in the blood, etc.);
Convulsions;
Irritation of the digestive tract;
Gastrointestinal bleeding;
Respiratory depression;
Liver failure.

Treatment of overdose consists of gastric lavage, taking sorbents (activated carbon, Polysorb, Polyphepan, Enterosgel, etc.) and laxatives, followed by maintaining the normal functioning of organs and systems.

Interaction with other drugs

Nise reduces the effect of Furosemide and enhances the effects of anticoagulants,

Cyclosporine

and lithium compounds. The risk of side effects increases when using Nise simultaneously with

Methotrexate glucocorticosteroids

and reuptake inhibitors

serotonin

Nise for children

Nise is approved for use in children only as prescribed by a doctor because, although in rare cases, it can cause severe side effects. Depending on the age of the child, it is recommended to use different shapes drug:

Children under 3 years old - only Nise suspension can be given;
Children 3 – 12 years old – you can give dispersible tablets or Nise suspension;
Children over 12 years old - Nise can be given in any form.

Dosages of the drug for children are also determined by age:

Children aged 2 months - 2 years - the dosage of the suspension is calculated individually according to body weight, based on the ratio of 1.5 mg per 1 kg of weight. The calculated daily amount of the drug is divided into 2 - 3 equal parts and given to the child 2 - 3 times a day;
Children aged 2 – 5 years – take 2.5 ml of suspension 2 – 3 times a day. The dosage of dispersible tablets is calculated individually according to the ratio of 3 – 5 mg per 1 kg of weight;
Children 5 – 12 years old – take 5 ml of suspension or 1 dispersible tablet 2 – 3 times a day;
Children over 12 years old - take the drug in an adult dosage in any dosage form, that is, 100 mg (10 ml suspension, 1 regular tablet or 2 dispersible tablets) 2 times a day.

Use during pregnancy and breastfeeding

Nise may have a negative impact on fertility,

pregnancy

pregnancy planning

The use of Nise is also contraindicated when

breastfeeding

Since it is unknown whether the drug is secreted in

Nise for pain, including dental

For pain of various localizations, Nise should be taken in the form of tablets or suspension a maximum of every 6 hours, that is, 4 times a day. Adults and children over 12 years of age are recommended to take 100 mg at a time, children 5–12 years old – 50 mg, and children 2–5 years old – 25 mg. Nise relieves pain well, but if the effect of the drug is not enough, then you should not take it often and a lot (for example, 2 - 3 tablets every 1 - 2 hours), but replace it with another one that has a stronger analgesic effect, for example,

Ketorol

Ketonal

Nise by temperature

Nise knocks down perfectly

temperature

Keeping it within normal limits for a fairly long period of time. However, since the drug can cause severe side effects, Nise should not be used, especially in children, as a first-line drug to reduce body temperature. It is recommended to use Nise as a last line treatment when Paracetamol and

Ibuprofen

turned out to be ineffective and after taking them the body temperature did not return to normal.

Alcohol compatibility

Since both alcohol and Nise have a toxic effect on the liver, their combined use is not advisable. When consumed alcoholic drinks Taking Nise significantly increases the risk of liver damage and the development of toxic

hepatitis A

Side effects of Nise

Regular and dispersible tablets, as well as Nise suspension, can provoke the following side effects from various organs and systems:

1. Allergic reactions:

Skin rash;
Bronchospasm;
Anaphylactic shock.

2. Central nervous system:

Dizziness;
Feeling of fear;
Nervousness;
Nightmares;
Headache;
Drowsiness;
Reye's syndrome.

3. Leather:

Rash;
Sweating;
Erythema;
Dermatitis;
Hives;
Quincke's edema;
Swelling;
Exudative erythema multiforme;
Lyell's syndrome;
Stevens-Johnson syndrome.

4. Urinary system:

Edema;
Pain when urinating;
Blood in the urine;
Urinary retention;
Increased potassium concentration in the blood;
Kidney failure;
Decreased amount of urine;
Interstitial nephritis.

5. Digestive tract:

Diarrhea;
Constipation;
Nausea;
Vomit;
Flatulence;
Gastritis;
Abdominal pain;
Stomatitis;
Tarry stools;
Bleeding from the gastrointestinal tract;
Stomach or intestinal ulcer.

6. Liver and bile ducts:

Hepatitis;
Jaundice;
Cholestasis.

7. Blood system:

Anemia;
Eosinophilia (increased number of eosinophils);
Pancytopenia (decreased number of platelets, red blood cells and white blood cells);
Purpura;

8. Respiratory systems:

Dyspnea;
Exacerbation bronchial asthma;
Bronchospasm.

9. The cardiovascular system:

Hypertension;
Heartbeat;
Hemorrhage;
Tides.

Other:

Blurred vision;
General weakness;
A decrease in body temperature below normal.

Gel Nise, as a rule, has only local side effects, such as itching, urticaria and peeling of the skin. However, when applying the gel to large areas of the skin, the following systemic side effects may develop due to the drug entering the bloodstream:

Heartburn;
Nausea;
Vomit;
Diarrhea;
Stomach pain;
Ulceration of the mucous membrane of the stomach or intestines;
Increased activity of AST and ALT;
Headache;
Dizziness;
Edema;
Blood in the urine;
Anaphylactic shock;
Skin rash;
Thrombocytopenia (decreased platelet count);
Leukopenia (decreased number of white blood cells);
Anemia;
Prolongation of bleeding time.

Contraindications for use

Gel Nise is contraindicated for use in the following conditions or diseases:

Dermatoses;
Skin damage;
Infectious-inflammatory in the area of application of the gel;
Pregnancy and breastfeeding period.

Suspension, tablets and dispersible tablets are contraindicated for use if a person has the following diseases or conditions:

Hypersensitivity to the components of the drug;
Bronchial asthma, combined with nasal polyps and intolerance to Aspirin or other NSAIDs;
Stage of exacerbation of erosive and ulcerative lesions of the digestive tract;
Gastrointestinal or bleeding of any other location;
Exacerbation of inflammatory bowel diseases;
Hemophilia;
Bleeding disorders;
Heart failure in the stage of decompensation;
Liver failure or liver disease in the acute stage;
Liver damage in the past that occurred while taking medications containing nimesulide;
Alcoholism;
Addiction;
Renal failure with creatinine clearance less than 30 ml/min;
Hyperkalemia (increased levels of potassium in the blood);
The first 2 - 3 months after coronary artery bypass grafting;
Pregnancy and breastfeeding period;
Age under 12 years for tablets, 3 years for dispersible tablets and 2 years for suspension.

Nise (tablets, gel): therapeutic effect, indications and contraindications - video

Nise - analogues

Currently, Nise has synonymous drugs and analogues on the pharmaceutical market. Synonyms are drugs that, like Nise, contain nimesulide as an active substance. Analogs of Nise are drugs from the NSAID group that have the most similar therapeutic effect.

Synonyms of tablets and suspension Nise

Actasulide tablets;
Ameolin tablets;
Aponil tablets;
Aulin granules and tablets;
Coxtral tablets;
Nemulex granules;
Nimesan tablets;
Nimesil granules and tablets;
Nimesulide granules and tablets;
Nimika dispersible tablets;
Nimulid suspension, tablets and lozenges;
Prolide dispersible tablets.

Gel Nise has only two synonymous drugs– these are the gels Nimulid and Sulaydin.

Analogues of tablets and suspension Nise are the following drugs:

Algesir Ultra tablets;
Arketal Rompharm solution for injection;
Brustan tablets;
Bystrumcaps capsules;
Vimovo tablets;
Dexalgin solution and tablets;
Diclofenac tablets and solution;
Ibuklin tablets;
Ibuprofen tablets and suspension;
Ibufen suspension;
Indomethacin tablets;
Ketonal capsules, solution, tablets, rectal suppositories;
Ketonal Duo capsules;
Ketoprofen tablets and solution;
Ketorol tablets and solution;
Meloxicam tablets and solution;
MIG 400 tablets;
Nalgesin tablets;
Naproxen tablets;
Next tablets;
Nurofen tablets, suspension, solution and gel;
OKI granules and rectal suppositories;
Rakstan-Sanovel tablets;
Solpaflex tablets;
Sirdalud tablets;
Sustilak tablets;
Flamax capsules and solution;
Flexen capsules, solution and rectal suppositories;
Flamadex solution.

Analogues of Nise gel The following medications are:

Bioran gel;
Butadione ointment;
Bystrumgel gel;
Voltaren Emulgel gel;
Diclak gel;
Diclobene gel;
Diclovit gel;
Diclogen gel;
Diclonate P gel;
Dicloran gel;
Diclofenac gel and ointment;
Diclofenacol cream;
Dolgit gel and cream;
Dorosan aerosol;
Ibalgin cream;
Ibuprofen ointment and gel;
Indobene gel;
Indomethacin gel and ointment;
Ketonal gel and cream;
Ketoprofen gel;
Nurofen gel;
Ortofen ointment and gel;
Orthofer ointment;
Piroxicam gel;
Fastum gel;
Finalgel gel;
Flexen gel.

Nise (gel, tablets, suspension) – reviews

More than 90% of reviews about Nise tablets are positive, due to the high effectiveness of the drug. In reviews, people note that the drug reliably relieves pain of various localizations (in muscles, dental, menstrual, traumatic,

radiculitisneuralgia

etc.) for 8 - 12 hours, which allows them to take the drug before bed and in the morning, and sleep normally the whole night, and during the day work productively or do household chores.

Also, most of the positive reviews about Nise tablets and suspension, used to reduce body temperature. However, these reviews, in addition to the positive characteristics of the effect of the drug, contain a warning against the constant use of Nise in children. This warning is due to the fact that the drug can cause a sharp and persistent decrease in temperature below normal and liver damage, and therefore it is not used in the first place in case of fever. In general, pediatricians recommend that to reduce the temperature, first give Paracetamol, if it does not work - Ibuprofen, and only if the latter is ineffective - Nise.

Many parents, fearing the possible negative effect of Nise, prefer to call “ ambulance"and give the child an injection with the so-called lytic mixture (Analgin + Paracetamol or Aspirin). However, this lytic mixture is much more dangerous for children than Nise, so if you have a persistent fever, you should not be afraid of this drug, but give it only if both Paracetamol and Ibuprofen are ineffective.

Depending on the frequency of adverse reactions, the incidence is divided into: often - (from 1% to 10%), sometimes (from 0.1% to 1%), rarely (from 0.01% to 0.1%), very rare (up to 0.01%).

Allergic: hypersensitivity reactions (rare); anaphylaxis, bronchospasm (very rare).
From the side of the central nervous system: feelings of anxiety, fear, nervousness, nightmares (rarely), dizziness, headache, drowsiness, encephalopathy (very rarely).
Dermatological: itching, rash, hyperhidrosis (uncommon); dermatitis, redness of the skin (rare); urticaria, Quincke's edema, epidermal necrolysis (very rare).
Nephrological: swelling (uncommon); dysuria, hematuria, anuria, hyperkalemia (rare); oliguria, renal failure (very rare).
From the gastrointestinal tract: dyspeptic symptoms (often); flatulence, constipation (uncommon), stomatitis, abdominal pain, bleeding in the gastrointestinal tract, tarry stools, ulcers and/or perforation of the stomach or duodenum (very rare).
From the hematopoietic organs: increased percentage of eosinophils in peripheral blood, anemia (rare); thrombocytopathy, increased bleeding time (very rare).
From the respiratory system: shortness of breath (uncommon); worsening of bronchial asthma (rare).
Cardiovascular: hypertension (uncommon); tachycardia, hemorrhage (rare).
Other: general weakness (rare); hypothermia (very rare).

Overdose

Symptoms: nausea, dizziness, vomiting, drowsiness, apathy. Possible increased blood pressure, respiratory depression, bleeding in the gastrointestinal tract, acute kidney failure.

Treatment: symptomatic, supportive, since there is no specific antidote to nimesulide drugs.

If no more than 4 hours have passed after the overdose, you should immediately induce vomiting in the patient, prescribe activated charcoal, and osmotic laxatives.

Accelerated diuresis or hemodialysis are not effective due to the high binding of the drug to blood proteins.

The release form of Nise is white-yellow, round, biconvex tablets with a smooth surface.

The medication is packaged in blisters of 10 tablets. A cardboard pack may contain 1, 2 or 10 blisters.

The most common side effects associated with the use of the drug Nise are the following conditions:

bronchospastic syndrome;
pain in the head area;
heartburn;
leukopenia;
anaphylactic shock;
agranulocytosis;
absentmindedness;
ulcerative lesions of the stomach or other organs of the gastrointestinal tract;
redness of the skin and the appearance of an itchy rash;
anemia;
intestinal disorder;
thrombocytopenia;
visual disturbances;
nausea and vomiting;
dizziness;
swelling of the limbs;
the appearance of traces of blood in the urine (hematuria).

Nimesulide enhances the effect of medications that help reduce blood clotting. At simultaneous use Nise with lithium preparations increases the likelihood of intoxication. Weakens the therapeutic effect of furosemide. The risk of bleeding in the gastrointestinal tract increases with the simultaneous use of serotonin reuptake blockers or glucocorticosteroids. Strengthens the negative effects of cyclosporine on the kidneys. With simultaneous use of methotrexate, the risk of adverse events increases.

The cost of the medicine is on average 337 rubles. Prices range from 159 to 716 rubles.

The presented pharmacological agent is rarely accompanied by negative concomitant phenomena. Most tablets are well tolerated, less than 5% of patients cannot take Nise - side effects include:

dizziness;
nervousness;
feeling of unreasonable fear;
nightmares;
drowsiness;
swelling of the face;
encephalopathy in the form of Reis' syndrome;
headache;
Lyell's syndrome;
immune hypersensitivity reactions;
skin rash (urticaria, eczema, dermatitis);
anaphylactic shock;
increased sweating;
exudative erythema multiforme;
angioedema;
Stevens-Johnson syndrome;
toxic epidermal necrolysis;
dysuria;
hyperkalemia;
urinary retention;
hematuria;
renal failure;
interstitial nephritis;
severe swelling of the extremities;
oliguria;
nausea;
constipation;
gastritis;
flatulence;
diarrhea;
vomit;
stomatitis;
pain in the epigastric region;
tarry soft stools;
exacerbation of peptic ulcer, perforation of the stomach or duodenum;
internal bleeding;
hepatitis, including fulminant form;
cholestasis;
drug-induced jaundice;
increased transaminase levels;
eosinophilia;
anemia;
pancytopenia;
increased duration of bleeding;
thrombocytopenia;
purpura;
exacerbation of bronchial asthma attacks;
dyspnea;
bronchospasms;
arterial hypertension;
tides;
tachycardia;
blurred vision or deterioration in its clarity;
hemorrhage;
general weakness, decreased performance;
a sharp decrease in body temperature.

People with certain medical conditions have a higher risk of developing these problems. In such situations, it is necessary to use Nise with extreme caution; side effects are more often observed in the following pathologies:

dysfunction of the kidneys and bladder;
eye diseases;
high blood pressure;
cardiovascular diseases;
severe liver damage.

Nimesulide is able to enter into chemical reactions with other non-steroidal anti-inflammatory drugs, so the simultaneous use of Nise and similar analgesics may result in unwanted side effects. It is not recommended to take the medication while planning pregnancy. The drug has been found to have a negative effect on female fertility.

Instructions for use of Nise tablets contain information about the composition, pharmacological properties, dosage, indications and contraindications of the drug.

The drug is available in tablet form. The cardboard package contains 2 blisters with a dozen tablets and an instruction leaflet. One tablet of the medicine contains 50 mg of nimesulide (the main active ingredient) and additional components.

Indications for the use of Nise tablets cover a wide range of human conditions and diseases. The drug is used as a non-steroidal anti-inflammatory drug that suppresses the synthesis of prostaglandins.

Pharmacological properties:

anesthesia;
elimination of inflammatory processes;
reduction of swelling;
reduction in fever.

Composition of Nise tablet:

100 g nimesulide;
dibasic calcium phosphate;
talc;
corn starch;
sodium starch glycolate;
talc;
polyvinylpyrrolidone;
magnesium stearate;
colloidal silicon dioxide.

If there are certain characteristics of the patient’s body, the following adverse reactions from taking the drug Nise may occur, such as:

allergies - it manifests itself in the form of rashes on the skin, rapid breathing, bronchodilator spasms, urticaria;
gastrointestinal disorder- the appearance of nausea, abdominal spasms, diarrhea, lack of appetite, flatulence, vomiting, belching with sour taste, increase in liver size, Crohn's disease, development of hepatic transaminases;
nervous disorders- they manifest themselves in the form of headaches and dizziness;
changes in the number of white blood cells, anemia or thrombocytopenia;
appearance ulcers and erosive changes in the duodenum and gastric mucosa;
bronchial asthma and recurrent polyposis of the paranasal sinuses or nose;
bleeding disorder, hemophilia.

After taking the drug, adverse reactions from the central nervous system, urinary system, skin, respiratory system, and sensory organs rarely occur.

All of the listed adverse reactions should be a reason to immediately consult a doctor.

An overdose of the drug can also cause similar conditions. Symptoms of overdose may include patient conditions such as drowsiness, apathy, diarrhea, nausea, increased blood pressure, gastrointestinal bleeding, difficulty breathing and renal failure.

As first aid, a victim of an overdose must empty the stomach and take an enterosorbent drug orally.

Considering the composition of the drug, you should not take it with medications such as Phenytoin, Digoxin, and drugs with lithium. When Nise interacts with these drugs, there will be no expected therapeutic effect.

Patients with diabetes mellitus and those using hypoglycemic drugs, if Nise therapy is necessary, need to keep their blood sugar levels under control.

Concomitant use of Nise and antihypertensive drugs can lower blood pressure.

It is prohibited to carry out simultaneous therapy with tablets with anticoagulants due to the high risk of internal bleeding. Also, you should not combine Nise with non-steroidal anti-inflammatory drugs.

Eugene. I consider it a good pain reliever, especially for toothache. Doctors do not recommend taking it on an empty stomach.

Alyona. Nise took the pills several times when her leg hurt to the point of lameness. Before that, I used the gel of the same name for leg pain. It helped.

Anya. But I didn’t like it because of the deterioration of my eyesight. I took it for neck pain. I felt better 1 hour after taking it. It turned out to be a strong drug, but the long list of side effects is frightening. Although it must be admitted that almost every painkiller has the same list.

Vladimir. My mother takes these pills in the morning for joint pain. I drank them a couple of times for headaches. They help both me and my mother. Just don’t take them more than the permitted limit.

Tablets for oral administration;
Dispersible tablets (soluble in a small amount of water) for oral administration;
Suspension for oral administration;
Gel for external use.

Nise - composition

Nise is a generic version of the original drug Nimesil. The following drugs are also analogues:

Nimesulide (tablets);
Nemulex (suspension);
Nimulid (tablets, suspension, gel, ointment);
Nimesan (tablets);
Nimica (tablets).

The price of Nise tablets depends on the markup of a particular pharmacy. The average price range is as follows:

Packaging 100 mg No. 10 140-170 rubles.
Packaging 100 mg No. 20 168-263 rubles.
Packaging 100 mg No. 30 257-349 rubles.

Cannot be used without consulting a specialist, there are contraindications!

Similar drugs to Nise tablets are drugs such as:

"Ibuprofen";
"Nimesil";
"Nimesulide";
"Nurofen";
"Nimika."

Before you start taking any medication, you should definitely consult your doctor to find out age restrictions, contraindications, dosage and other information.

Nise can be purchased without a prescription. The price of the tablet form ranges from 160 to 210 rubles. You can find out how much this drug will cost at the nearest pharmacy using one of the possible contact methods.

The medication in question goes on sale in blisters of 10 tablets, packed in cardboard packs.

Name:

Nise

Pharmacological
action:

The drug has antipyretic, anti-inflammatory, analgesic and antiplatelet effect. Suppresses the formation of prostaglandin at the site of inflammation, selectively inhibits COX2. Rarely may cause side effects due to inhibition of prostaglandin synthesis in healthy tissues. Slows down lipid peroxidation and has no effect on phagocytosis and hemostasis. When taken orally, it is absorbed quite well from the gastrointestinal tract. The maximum concentration of the drug is achieved 1.5–2.5 hours after administration. Its half-life is 3 hours. The main metabolite in its composition is the active hydroxynimesulide. In the liver this medicine biotransforms. Excretion is carried out mainly by the kidneys. Does not accumulate with prolonged use.

The drug is in the form of a gel has a local anti-inflammatory analgesic effect. With its help, pain in the joints weakens or disappears during movement and rest. Swelling and morning stiffness of the joints are neutralized.

Indications for
application:

This drug prescribed for the following diseases: osteoarthrosis, osteoarthritis, bursitis, tendovaginitis, tendonitis, rheumatism, ankylosing spondylitis, muscle pain, post-traumatic pain, spinal pain, infectious diseases, all kinds inflammatory processes, febrile syndrome, myalgia and neuralgia.

Nise in gel form used for degenerative and inflammatory diseases of the musculoskeletal system, such as rheumatoid and psoriatic arthritis, articular syndrome with exacerbation of gout and rheumatism, radiculitis, osteochondrosis with radicular syndrome, osteoarthritis, lumbago, bursitis, sciatica, inflammatory damage to tendons and ligaments.

Mode of application:

The drug is taken orally. For adults, two doses per day of 100 mg are prescribed. If necessary, the daily dose can be increased to a maximum of 400 mg.
Experts recommend taking the suspension or tablets before meals, but if you experience discomfort in the stomach, you can take the drug after meals.

Nise, presented in the form of dispersible tablets, should be dissolved in water (one tablet per teaspoon) and taken after meals.
Children over two years old the medicine is prescribed in the form of a suspension; for children over three years of age - in the form of a suspension or dispersible tablets. Older children (12 years and older) can take the tablets. The optimal dose for them should be calculated based on body weight: 3-5 mg per kg. Adolescents who have reached a weight of 40 kg can take the medicine at an adult dose - 100 mg twice a day.

Nise in gel form applied to the skin. Before this, the desired area of skin should be thoroughly washed and dried. A column of gel, 3 cm long, is applied to the most painful area and rubbed to a thin, uniform layer. This procedure should be carried out 3-4 times a day.

The drug can be used for 10 days.

Side effects:

While using this medicine The following side effects have been noted: headache, drowsiness, dizziness, nausea, diarrhea, vomiting, heartburn, gastralgia, stomach pain, tarry stools, toxic hepatitis, ulceration of the gastrointestinal mucosa, petechiae, melena; purpura, oliguria, fluid retention, anemia, leukopenia, thrombocytopenia, agranulocytosis, hematuria, high activity of “liver” transaminases. Various allergic reactions such as anaphylactic shock or skin rash also occur.

When using gel Local adverse reactions may occur: urticaria, itching, peeling of the skin. If there is a transient change in skin color, then discontinuation of the medication is not required. When applying the gel to large areas of the skin, one cannot exclude systemic side effects that are typical when taking tablets and are listed above.

If any side effects are noticed, you should stop taking the medication and consult a doctor for advice.

Contraindications:

Erosive and ulcerative lesions of the gastrointestinal tract in the acute phase;
- bleeding from the gastrointestinal tract;
- “aspirin triad”;
- liver dysfunction;
- severe renal failure (CR<30 мл/мин);
- pregnancy;
- lactation (breastfeeding);
- dermatoses, damage to the epidermis, skin infections in the area of application (for gel);
- children under 2 years of age;
- hypersensitivity to nimesulide and other components of the drug, acetylsalicylic acid and other NSAIDs.
Prescribe with caution drug for arterial hypertension, heart failure, diabetes mellitus type 2 (non-insulin dependent).

Interaction
other medicinal
by other means:

Potential drug interactions(due to competition between drugs for binding to proteins) while taking Nise orally with digoxin, phenytoin, lithium drugs, diuretics, antihypertensive drugs, other NSAIDs, anticoagulants, cyclosporine, methotrexate, oral hypoglycemic agents.

Pregnancy:

Nise contraindicated for use during pregnancy.
If it is necessary to use the drug during lactation, the issue of stopping breastfeeding should be decided.

Overdose:

Symptoms overdose is an increase in the severity of adverse reactions. As a rule, this is impaired renal function, liver failure, irritation of the gastrointestinal tract, convulsions, respiratory depression, and increased blood pressure.

Treatment: If any of these symptoms appear, you should immediately stop taking the drug and provide treatment: first of all, rinse the stomach, take activated charcoal and carry out symptomatic therapy. There is no clearly defined antidote. Hemodialysis and forced diuresis do not bring the desired results.

Suspension for oral administration yellow in color, with a pleasant odor and characteristic taste, redisperses when shaken.
Nimesulide - 50 mg
Excipients: sucrose, sorbitol, methylparaben, propylparaben, xanthan gum, citric acid, quinoline yellow WS, pineapple flavor, polysorbate 80, glycerol, purified water.

Gel 20 g tube contains:
Nimesulide 10 mg/g, Methyl salicylate 100 mg/g, Menthol 50 mg/g, Capsaicin 0.25 mg/g
Other Ingredients: diethyl phthalate, diethylene glycol monoethyl ether, polyethoxylated hydrogenated castor oil, propylene glycol, sodium benzoate (E211), disodium edetate, butylated hydroxytoluene (E 321), carbomer, trometamol, purified water.