If a woman decides to terminate the pregnancy, but excludes surgical intervention If the pregnancy is no more than 6 weeks old, the gynecologist may recommend a medical abortion. For this type of abortion, large doses of mifepristone are prescribed.
Ginepristone contains only 10 mg of mifepristone and is used as a remedy " emergency contraception» after unprotected sexual intercourse.
How does Gynepriston work?
Gynepristone blocks the production of progesterone, which is necessary for normal pregnancy.
When progesterone is blocked, the inner layer of the uterus detaches. Detachment of the endometrium leads to softening and expansion of its neck. With an enlarged cervix and increased contractile activity, bleeding begins. Ginepristone, after taking a precisely calculated dose, leads to fetal rejection. The effectiveness of Ginepristone increases in combination with prostaglandin.
Gynepristone is a synthetic steroidal antigestagenic agent. Its effect depends on the stage of ovulation - it either inhibits it or changes the properties of the endometrium, preventing the implantation of a fertilized egg.
Side effects of Gynepristone
- Bleeding and cramping pain. This is a normal reaction to termination of pregnancy;
- nausea, any other symptoms of dyspepsia;
- weakness, asthenia, headache;
- hives;
- hyperthermia;
- inflammatory and infectious processes in the pelvic organs;
- at ectopic pregnancy this drug may cause the fallopian tube to rupture. This can be fatal;
- abdominal pain, pulling or aching, back pain.
The difference between Ginepristone and Postinor is the dosage regimen. One tablet is taken within 72 hours after sexual intercourse. The timing of taking Gynepristone does not affect its effectiveness. The drug is better absorbed if you drink it on an empty stomach and refrain from eating for another 2 hours after taking the tablet. Mifepristone in small doses usually does not cause adverse reactions.
Contraindications to the use of Ginepristone
- Pregnancy and lactation period. If taking Ginepristone is mandatory, stop breastfeeding for 2 weeks;
- adrenal insufficiency, renal failure and long-term use of glucocorticosteroids;
- pathologies of the pelvic organs;
- history of hypersensitivity to mifepristone drugs;
- bleeding disorders;
- bronchial asthma and other lung diseases;
- hypertension, arrhythmias, heart failure.
Gynepristone cannot be used as a method of permanent contraception. And the simultaneous use of NSAIDs (ibuprofen, diclofenac, naproxen, etc.), acetylsalicylic acid and mifepristone drugs is excluded.
Ginepristone should not be used in children under 18 years of age. A teenager who takes emergency contraception may violate menstrual cycle. And it will be difficult to restore it. Due to the unformed hormonal background of a teenager, the drug may simply not work or cause bleeding.
After taking Gynepristone, you should visit a gynecologist. He must confirm that pregnancy has not occurred. Or at least take some pregnancy tests.
If unprotected sexual intercourse occurs, the condom breaks. The woman is firmly convinced that if pregnancy occurs, she will not maintain it - she should take a post-coital contraceptive. Unlike abortion pills, Ginepriston simply prevents pregnancy from occurring. From a psychological and physical health women are the best option.
Publication date: 2019-05-29
This article is posted for educational purposes only and does not constitute scientific material or professional medical advice.
Each tablet contains 0.01 g of active substance - mifepristone . Also added excipients: 0.0746 g microcellulose , 0.0045 g sodium carboxymethyl starch and 0.0009 g calcium stearate .
Release form
Available in the form of flat-cylindrical tablets of light yellow color, which weigh 0.01 g. Each tablet separately or two tablets together are placed in a blister pack or a polymer jar. Each blister pack or polymer jar is contained in a cardboard pack.
pharmachologic effect
Possesses antigestagenic effect .
Pharmacodynamics and pharmacokinetics
Pharmacodynamics
Ginepristone is a synthetic steroidal antigestagenic drug - it has the property of blocking the action at the receptor level.
Its action stimulates increased contractility myometrium , promotes the release of substances that increase the sensitivity of the myometrium to certain types of hormones. Depending on what phase of the menstrual cycle the drug was taken, it may cause inhibition ovulation , promote change, and also hinder implantation already fertilized egg.
Pharmacokinetics
Maximum concentration in the blood after taking a single dose of 600 mg of the drug is achieved after 1-1.5 hours.
Absolute bioavailability Ginepristone is 69%.
98% of the drug entering the blood binds to plasma proteins, in particular.
Removal from the body is uneven. At first, the concentration is halved slowly (up to 72 hours), then much faster. The half-life is 18 hours.
Indications for use
Gynepristone is used as an interruption, that is, in cases where sexual intercourse was unprotected or if the method of contraception used during it turned out to be unreliable.
Contraindications
Contraindications include:
- presence in the anamnesis of indications of hypersensitivity To mifepristone ;
- adrenal insufficiency and long-term therapy glucocorticosteroids ;
- acute and chronic renal and/or liver failure;
- severe form extragenital pathology .
You should be careful when using Ginepristone when:
- various violations hemostasis (including disorders caused by previous treatment anticoagulants );
- chronic obstruction obvious lung diseases (For example, );
- severe arterial hypertension ;
- heart rhythm disturbances;
- heart failure .
Side effects
Side effects of Ginepristone may include a feeling of discomfort in the lower abdomen, weakness, headache, nausea, vomiting , hyperthermia , bloody discharge from the genital tract may appear.
Instructions for use (Method and dosage)
Take 1 tablet orally no later than 72 hours after unprotected sexual intercourse. Do not eat food for 2 hours before and after taking the drug.
Ginepristone is used in any phase of the menstrual cycle.
Overdose
In cases of taking Ginepristone in doses not exceeding 2 g, adverse reactions are unlikely. When taking a larger dose of the drug, the functioning of the adrenal glands may be disrupted and they may develop. failure .
Interaction
Contraindicated simultaneous use With non-steroidal anti-inflammatory drugs .
Terms of sale
Sold by prescription.
Storage conditions
Should be stored in a dry place protected from light. Temperature environment should not exceed 30 °C. The place where the tablets are stored should be out of reach of children.
Best before date
special instructions
It is not advisable to use regularly as a means of permanent, planned contraception.
Ginepristone is a synthetic steroid drug that is part of the group of gestagens and is used as an emergency, effective means of rapid contraception. The main active ingredient of the drug is mifepristone.
How to use this drug? In what dosage should I take gynepristone, what are the consequences of the action, what can I replace it with? You can easily find all the answers to these questions in the factory instructions. If you don’t have it at hand, read the description of the drug that we compiled based on it.
The description is presented for the purpose of familiarization with the drug, and, of course, is not a guide to action. Therefore, before using this product, carefully read the instructions yourself.
What is the effect of Ginepriston?
As we have already said, Ginepristone is prescribed for emergency use after an unprotected act has occurred, since in this case there is a high probability of an unwanted pregnancy.
The action of the drug is aimed at enhancing the contraction of the myometrium, increasing its sensitivity to prostaglandins. Regardless of the phase of the menstrual cycle, if a Ginepristone tablet was taken, the drug causes inhibition of ovulation, and an active change in the endometrium occurs. All this prevents implantation, the attachment of a fertilized egg.
At all, this remedy It is considered by doctors and patients to be one of the most reliable for preventing pregnancy.
What are the analogues of Ginepriston?
Gynepristone has several structural analogues that have one active substance. Therefore, if necessary, it can be replaced with such agents as: Ginestril, Agesta, Zhenale. Also effective: Miropriston, Mifegin and Mifeprex. Mifepristone and Pencrofton can be used.
What are Ginepriston's indications for use? What do the instructions say?
Ginepristone is intended to protect women from the onset of unplanned pregnancy when unprotected or insufficiently protected sexual intercourse has occurred.
What is the use of Ginepriston?
The tablet is taken no later than three days (72 hours) after direct sexual intercourse. To achieve greatest effect, before taking the tablet, you should refrain from eating or drinking for 2 hours. Please note that it is also not recommended to eat or drink within 2 hours after taking the tablet.
The drug does not affect the menstrual cycle in any way. Therefore, it can be taken at any time when needed.
What are the side effects of Ginepriston?
After taking the drug, negative reactions of the body may be observed. For example, women often complain of headaches, dizziness, nausea and vomiting, or pain in the lower abdomen. Sometimes observed bloody issues, skin rashes. The temperature may rise. Women complain of general weakness, and cycle disorders may appear.
But it must be said that side effects from taking the drug are not often observed. Usually the drug is tolerated quite well. However, before using this medicine, talk to your gynecologist about your intentions. This is also important because Gynepristone has many contraindications, which, of course, must be taken into account before taking the pills.
What are the contraindications for Ginepriston?
Among the contraindications of Ginepristone, the instructions for use list a number of conditions that must be studied:
Women with adrenal, kidney or liver insufficiency should not take this drug.
The drug is not prescribed to women with chronic diseases for which they regularly or for a long time take drugs such as prednisolone, hydrocortisone, dexamethosone. It is also contraindicated in patients taking medications that affect blood clotting.
Do not take Ginepriston with simultaneous treatment with non-steroidal drugs (indomethacin, analgin, as well as paracetamol, aspirin, etc.), which are intended for treatment inflammatory diseases.
The use of Ginepristone is contraindicated in the presence of severe acute diseases or aggravated chronic ones.
If during breastfeeding If you have taken a Gynepristone tablet, you will be able to resume feeding your baby with your milk only two weeks after taking the tablet.
Take this medicine with caution if the patient suffers from heart rhythm disturbances, if there is insufficiency, or if blood clotting is impaired.
Always remember that Ginepristone cannot in any way be used as a drug for regular contraception. It is taken only in emergency situations and exceptional cases. You also need to know that the drug will not be able to protect a woman from sexually transmitted diseases. So be careful, take care of yourself and your health.
Gynepristone is a popular emergency contraceptive with a high effectiveness of 97%. The drug in combination with other medications is also used for medical purposes. . Women are often interested in how to take gynepristone correctly and whether it is possible to perform a medical abortion with this drug at home.
CONSULTATION ON THE RESULTS OF ANALYSIS AND ULTRASOUND - 500 rubles. (at the request of the patient) Medical abortion - from 3500 (all inclusive!)
How does gynepristone work?
The active ingredient of the drug is mifepristone, a synthetic steroid that inhibits the production of progesterone.
Progesterone is a hormone that is actively produced during ovulation, creating conditions for the implantation of a fertilized egg into the uterine cavity. Thanks to special hormonal levels, the uterus does not contract when a zygote enters there, and it quietly implants (attaches) to the walls of the organ, and then develops, forming an embryo.
Ginepristone creates unfavorable conditions for conception by slowing down ovulation. The result of suppressing progesterone production is that the endometrium (the inner layer of the uterus) remains underdeveloped, so the egg cannot implant.
If you are already pregnant, this synthetic progestogen enhances the effect of prostaglandins that stimulate labor. Prostaglandins are used during childbirth, but a similar effect has also been seen on early stages pregnancy - in other words, when taking gynepristone, it begins .
Mifepristone contained in the drug stimulates the sensitivity of receptors to prostaglandins and blocks the perception of progesterone. As a result, changes occur in the endometrial layer. The smooth muscles of the uterus begin to contract rhythmically under the influence of prostaglandins, pushing the fertilized egg out of the cavity.
How does Gynepriston differ from analogues and why is it not suitable for medical abortion?
Ginepristone - analogue and other drugs based on this active substance (Agesta, Zhenale, Ginestril, Escapelle). But it contains a small dose of the active substance - 0.01 g. Therefore, it is used as a means of emergency contraception when sexual intercourse has occurred, but conception (fusion of germ cells) has not yet occurred.
They contain a dose ten times higher than the content of mifepristone in gynepristone. If you take genipristone at home during pregnancy, in the form in which it is sold in pharmacies, there is a 99% chance that your pregnancy will continue. There are cases when, after taking the drug, menstruation begins, but the fetus still remains in the uterus. As a result, a woman discovers pregnancy when the fetus has already begun to move. It is no longer possible to talk about abortion at this stage, so childbirth is coming. But it’s difficult to imagine how such experiments will affect a child.
At the same time, gynepristone can be chosen as emergency contraception. All drugs - analogues of gynepristone - act on the body according to the same principle, having the active substance mifepristone. But despite the large selection of contraceptives, Ginepriston is very popular and is characterized by positive reviews from gynecologists. This is due to the fact that the medicine does not affect ovulation and spares the ovaries.
This drug is also prescribed by gynecologists for the treatment of tumors and cysts. Naturally, the choice of medicine should be made only after passing and passing . This is due to the fact that the medicine is effective only up to a certain size of tumors; beyond this limit, on the contrary, it can provoke their growth.
How to take Gynepristone
Gynepristone is considered a very effective post-coital contraceptive that prevents pregnancy as a result of unprotected intercourse. For many years, the drug Postinor was very popular. It has proven itself really well and is highly effective, but it provokes hormonal disruption, suppressing the release of the oocyte from the follicle. If Postinor is used incorrectly, a woman could develop an ovarian cyst or other problems. There will be no such problems with Ginepristone, and its effectiveness is very high.
The drug can be taken both before and after sexual contact. The highest concentration of mifepristone is achieved 24 hours after taking the tablet. Then every 12 hours the effectiveness decreases by 20-25%.
By taking Gynepristone within 24 hours after unprotected intercourse, you can be 97% sure that conception will not occur. After 3 days the drug becomes ineffective. You can take the medicine on any day of the cycle.
If gynepristone was taken and pregnancy still occurred, you will have to have an abortion (medical, , ), because there is a high risk of having a child with pathologies.
As a rule, after taking the medication, menstruation occurs on time or a few days earlier. Delay is rare.
What nuances should you pay attention to when taking Gynepristone: contraindications
Gynepristone - high effective remedy emergency contraception, but there are a number of caveats:
- The manufacturer writes that taking this medication is incompatible with smoking by women over 35 years of age. In fact, smoking reduces the effectiveness of mifepristone, regardless of the girl's age. Having smoked several cigarettes, a woman at both 20 and 38 years old increases the chances of an unwanted pregnancy;
- It is important not to take Gynepristone on a full stomach. The drug provokes muscle contractions, including gastric ones, causing vomiting. After it, the action is reduced to nothing.
- You should not use emergency contraception more than 1-2 times a year. If a woman took 200 mg of drugs containing mifepristone over 2 months and did not become pregnant, then the next time 10 mg of gynepristone will not have any effect at all. In this case, it is better to use stronger agents such as Postinor or Escapella. But they have significant drawbacks: Escapelle is effective only in the first phase of the cycle, and Postinor causes hormonal imbalance and amenorrhea. Ginepristone is good as the first means of emergency contraception, gentle on the body.
- The drug should not be taken together with analgesics (No-shpa, Analgin, Paracetamol). In this case, problems with the heart and blood vessels, a strong increase in pressure and the opening of uterine bleeding are possible.
- Ginepristone is contraindicated in women with arrhythmia, heart failure and arterial hypertension.
What side effects does Gynepriston have?
Despite the fact that Ginepristone is a relatively safe emergency contraceptive for a woman’s body, it, like all medications, has side effects. In particular:
- PMS symptoms are more pronounced. Deterioration of mood, increase blood pressure, headache, nagging pain in the lower abdomen - a natural side effect of antiprogesterones. The advantage of Gynepristone is that these symptoms do not last long because menstruation occurs on time or a few days earlier.
- The drug enhances the effect of drugs aimed at blood clotting. If a woman is undergoing treatment and taking coagulants, she should stop using Gynepristone.
- The drug reduces the effect of glucocorticosteroids (Hydrocortisone, Dexamethasone, Prednisolone), so it should not be taken by people with adrenal and renal insufficiency.
In general, Gynepristone is well characterized by both patients and gynecologists. It does not have such a stressful effect on the body as Postinor, which has a significant proportion of hormones. But you should still first consult with a gynecologist, who will select a reliable means of emergency contraception in accordance with the patient’s health characteristics.
Where to find emergency contraception or medical abortion in St. Petersburg
At the Diana Clinic in St. Petersburg, you can take all the tests, undergo a specialized female ultrasound using a new device and get a consultation with an experienced gynecologist with the highest category. The doctor will prescribe a drug that will leave minimal consequences after the termination of an unwanted pregnancy.
One of the main functions of using various protections during sexual intercourse is to prevent unplanned pregnancy. But what to do if contraceptives were not at hand or they turned out to be of poor quality? In these cases, the solution may be so-called post-coital contraceptives, that is, drugs taken after unprotected intercourse. One of the most effective and proven drugs of this type is Ginepristone.
In contact with
Description of the drug and its benefits
Ginepristone is a synthetic steroid drug with a pronounced antigestagenic effect. Its essence lies in blocking the interaction of the hormone progesterone and the receptors that capture it. Due to this, the fertilized egg cannot attach to the endometrium and is soon excreted from the body. If the period of ovulation has not yet occurred, the drug prevents its onset.
Compared to other contraceptives of this kind, the drug has clear advantages. The main thing is the non-hormonal nature of the drug, which avoids problems with the endocrine system when using it. That is, the drug has a milder, but no less effective effect, which has been confirmed by practice.
Important! Another important detail is the absence of gestagenic activity, that is, the use of Gynepristone does not affect the ability to become pregnant in the future.
The pharmacokinetic characteristics of the contraceptive allow it to achieve maximum serum concentration within 2 hours when taking a single dose of 600 mg. At the same time, the connection with proteins is almost 100%. The half-life is about 18 hours. In particular, a decrease in concentration by half occurs between 12 and 72 hours after administration (depending on the organism). The remaining metabolites leave the body much faster - in 7-12 hours.
Indications for use and use
When and how to take postcoital contraceptive? The main indication for use of the drug is emergency contraception after unprotected sexual intercourse or in case of ineffectiveness/damage of other means (for example, perforation (rupture) of a condom). In these cases, to prevent unplanned pregnancy, it is necessary to take Ginepristone as soon as possible, no more than 3 days after coitus.
It is advisable to check the dose with your gynecologist, but in most cases one tablet (10 mg of mifepristone) is sufficient. For achievement desired effect It is recommended to avoid eating 2 hours before taking the pill and for 2 hours after. The dosage can be increased depending on the phase of the cycle. The main reason for this is that ovulation has already occurred. The instructions for use indicate that the maximum safe dose that can be taken is 2 g, but such decisions should be made solely by the supervising physician.
The dosage of the drug should be checked with a gynecologist.
Contraindications and side effects
Like any drug, Ginepristone has a number of contraindications. Among them:
- renal failure;
- liver failure;
- long-term therapy with glucocorticosteroids;
- disruption of the endocrine system associated with the production of estrogen;
- chronic diseases of the genitourinary system;
- hypersensitivity to the components of the drug.
In addition, the contraceptive should be taken with caution if you have problems with the cardiovascular system, such as heart failure or arrhythmia. The medicine is taken under supervision in case of impaired blood clotting, diagnosed chronic obstructive pulmonary disease (COPD), or problems with blood pressure.
When using the drug Ginepristone side effects may also occur. They are mainly caused by a violation of the dosage or dosage regimen. Such conditions include:
- migraine;
- elevated temperature (sometimes up to 39°C and above);
- general weakness;
- nausea, sometimes with vomiting;
- abundant bleeding from the genitals;
- hives;
- menstrual irregularities;
- pain and other manifestations of discomfort in the pelvic area.
Important! When using Gynepristone during lactation it is necessary stop breastfeeding for a period of at least 2 weeks.
Overdose may cause disruption of the adrenal glands. In these cases, mandatory consultation with a specialist and symptomatic treatment are necessary.
Advantages of the drug
Features of use and storage
How often can I use the drug? The use of Gynepristone as postcoital contraception on an ongoing basis is strictly not recommended. Otherwise, the effectiveness of its action is reduced, initially amounting to 98.8%. In addition, the development of adrenal insufficiency and various liver and kidney dysfunctions may be a consequence. During use, driving vehicles and other machinery is permitted.
Important!Medicine It is used only as a solution to the issue of unwanted pregnancy - it does not function as a barrier to sexually transmitted diseases.
If we talk about the compatibility of the drug with other drugs, the simultaneous use of Ginepristone and non-steroidal anti-inflammatory drugs (NSAIDs, ibuprofen, diclofenac) is not recommended. If such a “neighborhood” is necessary, the dose of NSAIDs must be adjusted. One of the burning questions for female representatives is: “Is Gynepristone sold by prescription or not?” Yes, purchase of the drug requires a prescription, so you should ensure its availability in advance.
The drug belongs to list A. It should be stored in a dark, dry place, at a temperature not exceeding 30° C. The maximum shelf life is 36 months.
To purchase the drug, you must take a prescription from a doctor.
Analogues and comparison with them
Below is a list of the most common analogues of Ginepristone and their relative comparison with it:
- Agesta. It is a complete analogue, that is, it has an absolutely identical composition. Consequently, it has all the advantages and disadvantages of the drug in question. It also loses effectiveness with constant use. The average cost is 130 rubles.
- Ginestril. The drug has a wider list of side effects. The advantage is the extended spectrum of action - it is often prescribed as prevention of uterine leiomyomas, one of the common causes of infertility. The average cost is 5620 rubles.
- Genale. The effect of this drug, when used regularly, is much more serious than the corresponding characteristic of Ginepristone. If pregnancy occurs while using it, there is a high risk of having a child with congenital pathologies. The average cost is 300 rubles.
- Miropriston. It is considered one of the most effective postcoital contraceptives. Under its influence, a sharp contraction of the uterus occurs during the day, which leads to rejection of the fertilized egg. It is not commercially available and is prescribed exclusively by the supervising physician. It has a considerable list of side effects. The average cost is 2200 rubles.
- Mifeprex. The drug is taken only in the presence of a doctor in a medical facility, where the woman spends another 2 hours under observation. The list of contraindications is wider, but it is possible to use it much later than within 72 hours after sexual intercourse. It is, in fact, a method of pharmaceutical abortion, therefore it can only be purchased with a doctor’s prescription. The average cost is 1200 rubles.
- Mytholian. It is almost a complete analogue of Mifeprex, therefore it has a similar type of effect and characteristics. Its use is permitted up to one and a half months after the last menstruation. Distributed in pharmacies only upon presentation of a prescription. The average cost is 1200 rubles.
- Mifotab. Another analogue similar to Mifeprex. Possessing an almost identical composition, it has reduced efficiency(about 80%) and a greater number of contraindications. Available only by prescription. The average price is 2000 rubles.
- Pencrofton. In many ways similar to Ginepriston. It has the same efficiency and similar characteristics. The average cost is 3000 rubles.
Ginepristone, like many of the drugs listed, is sold by prescription at an average price of 430 rubles.
