Catad_pgroup Vitamins and minerals

Ascorbic acid- instructions for use

INSTRUCTIONS
By medical use drug

Registration number:

Tradename: ASCORBIC ACID

International nonproprietary name:

Ascorbic acid.

Dosage form:

dragee.

Compound:

Composition for one dragee:
Active substance: 0.05 g ascorbic acid;
Excipients: sugar, starch syrup, wheat flour, sunflower oil, beeswax, talc, food flavorings, yellow dye E 104.

Description
Dragee greenish-yellow or yellow color regular spherical shape. The surface of the dragee must be flat, smooth, and uniform in color.

Pharmacotherapeutic group
A drug that regulates metabolic processes.
Vitamin preparation.

ATX Code A11GA01

Pharmacological properties
Ascorbic acid is actively involved in many redox reactions and has a nonspecific general stimulating effect on the body. Increases the body's adaptive abilities and its resistance to infections; promotes regeneration processes.

Indications for use
Prevention and treatment of hypo- and vitamin C deficiency;
As an adjuvant: hemorrhagic diathesis, nasal, uterine, pulmonary and other bleeding, against the background of radiation sickness; overdose of anticoagulants, infectious diseases and intoxications, liver diseases, nephropathy of pregnancy, Addison's disease, slow-healing wounds and bone fractures. dystrophies and other pathological processes. The drug is prescribed for increased physical and mental stress, during pregnancy and breastfeeding, during the period of recovery after serious long-term illnesses.

Contraindications
Increased sensitivity to the components of the drug, thrombophlebitis, tendency to thrombosis, diabetes mellitus.

Carefully: hyperoxalaturia, renal failure, hemochromatosis, thalassemia, polycythemia, leukemia, sideroblastic anemia, glucose-6-phosphate dehydrogenase deficiency, sickle cell anemia. Progressive malignant diseases, pregnancy.

Directions for use and doses
The drug is taken orally after meals.
For prevention: adults 0.05-0.1 g (1-2 tablets) per day, children over 5 years old 0.05 g (1 tablet) per day.
For treatment: adults 0.05-0.1 g (1-2 tablets) 3-5 times a day, children from 5 years old 0.050.1 g (1-2 tablets) 2-3 times a day.
During pregnancy and breastfeeding, 0.3 g (6 tablets) per day for 1015 days, then 0.1 g (2 tablets per day) per day.

Side effect
From the central nervous system (CNS): headache, feeling of fatigue, with prolonged use of large doses - increased excitability of the central nervous system, sleep disturbances.
From the outside digestive system: irritation of the gastrointestinal mucosa, nausea, vomiting, diarrhea, stomach cramps.
From the endocrine system: inhibition of the function of the insular apparatus of the pancreas (hyperglycemia, glycosuria).
From the urinary system: when used in high doses, hyperoxalaturia and the formation of urinary stones from calcium oxalate.
From the cardiovascular system: thrombosis, when used in high doses - increased blood pressure, development of microangiopathies, myocardial dystrophy. Allergic reactions: skin rash, rarely - anaphylactic shock.
Laboratory indicators: thrombocytosis, hyperprothrombinemia, erythropenia, neutrophilic leukocytosis, hypokalemia.
Others: hypervitaminosis, feeling of heat, with prolonged use of large doses - sodium (Na +) and fluid retention, metabolic disorders of zinc (Zn 2+), copper (Cu 2+).

Overdose
When taking more than 1 g per day, heartburn, diarrhea, difficulty urinating or red urine, and hemolysis (in patients with glucose-6-phosphate dehydrogenase deficiency) are possible.
If any side effects you should stop taking the drug and consult a doctor.

Interaction with other drugs
Increases the concentration of benzylpenicillin and tetracyclines in the blood; at a dose of 1 g/day increases the bioavailability of ethinyl estradiol.
Improves the absorption of iron preparations in the intestines (converts ferric iron to divalent iron); may increase iron excretion when used concomitantly with deferoxamine.
Acetylsalicylic acid (ASA), oral contraceptives, fresh juices and alkaline drinks reduce absorption and absorption.
When used simultaneously with ASA, the urinary excretion of ascorbic acid increases and the excretion of ASA decreases. ASA reduces the absorption of ascorbic acid by approximately 30%.
Increases the risk of developing crystalluria during treatment with salicylates and short-acting sulfonamides, slows down the excretion of acids by the kidneys, increases the excretion of drugs that have an alkaline reaction (including alkaloids), and reduces the concentration of oral contraceptives in the blood.
Increases the overall clearance of ethanol, which, in turn, reduces the concentration of ascorbic acid in the body.
Quinoline drugs (fluoroquinolones, etc.), calcium chloride, salicylates, and glucocorticosteroids with long-term use deplete ascorbic acid reserves.
When used simultaneously, it reduces the chronotropic effect of isoprenaline.
Long-term use or use in high doses may interfere with the disulfiram-ethanol interaction.
In high doses, it increases the renal excretion of mexiletine.
Barbiturates and primidone increase the excretion of ascorbic acid in the urine.
Reduces the therapeutic effect of antipsychotics (phenothiazine derivatives), tubular reabsorption of amphetamine and tricyclic antidepressants.

special instructions
Due to the stimulating effect of ascorbic acid on the synthesis of corticosteroid hormones, it is necessary to monitor renal function and blood pressure.
With long-term use of large doses, inhibition of the function of the pancreatic insular apparatus is possible, so it must be regularly monitored during treatment.
In patients with high iron levels in the body, ascorbic acid should be used in minimal doses.
Prescribing ascorbic acid to patients with rapidly proliferating and intensively metastasizing tumors can aggravate the process.
Ascorbic acid, as a reducing agent, can distort the results of various laboratory tests (blood glucose, bilirubin, transaminase activity, LDH).
Use during pregnancy and breastfeeding
The minimum daily requirement for ascorbic acid is P-P trimesters pregnancy - about 60 mg.
The minimum daily requirement during breastfeeding is 80 mg. A maternal diet containing adequate amounts of ascorbic acid is sufficient to prevent vitamin C deficiency in infant(it is recommended that a nursing mother not exceed the maximum daily requirement for ascorbic acid).

Release form
200 tablets in polymer jars BP-60-X or BP-60, or “BP-60-X with stopper.”
Instructions for medical use are included in the stopper (case) of the “BP-60 X with stopper” jar without putting the jar into the pack.
A polymer jar BP-60-X or BP-60 is placed in a cardboard pack along with instructions for medical use.

Best before date
1 year 6 months.
Do not use after the date indicated on the package.

Storage conditions
In a dry place, protected from light.
Keep out of the reach of children.

Conditions for dispensing from pharmacies
Over the counter

Manufacturer and organization accepting claims:
JSC Pharmstandard-UfaVITA, 450077 Ufa, st. Khudayberdina, 28.

Comments

(visible only to specialists verified by the MEDI RU editorial team)

Ascorbic acid - price, availability in pharmacies

The price at which you can buy Ascorbic acid in Moscow is indicated. You will receive the exact price in your city after switching to the online medicine ordering service.

Vitamin preparation

Active substance

Release form, composition and packaging

100 pieces. - polymer jars (1) - cardboard packs.
200 pcs. - polymer jars (1) - cardboard packs.

pharmachologic effect

Ascorbic acid () is not formed in the human body, but comes only with food.

Pharmacological effects: in quantities significantly exceeding the daily requirement (90 mg), it has almost no effect, with the exception of the rapid elimination of symptoms of hypo- and vitamin deficiency (scurvy).

Physiological functions: is a cofactor in some hydroxylation and amidation reactions - it transfers electrons to enzymes, providing them with a reducing equivalent. Participates in the reactions of hydroxylation of proline and lysine residues of procollagen with the formation of hydroxyproline and hydroxylysine (post-translational modification of collagen), oxidation of lysine side chains in proteins with the formation of hydroxytrimethyllysine (in the process of kartinite synthesis), oxidation to folinic acid, metabolism medicine in liver microsomes and hydroxylation of dopamine to form norepinephrine.

Increases the activity of amidating enzymes involved in the processing of oxytocin, antidiuretic hormone and cholecystokinin. Participates in steroidogenesis in the adrenal glands;

Restores Fe 3+ to Fe 2+ in the intestines, promoting its absorption. The main role in tissues is participation in the synthesis of collagen, proteoglycans and other organic components of the intercellular substance of teeth, bones and capillary endothelium.

In low doses (150-250 mg/day orally) it improves the complexing function of deferoxamine in chronic intoxication with iron preparations, which leads to increased excretion of the latter.

Ascorbic acid is actively involved in many redox reactions and has a nonspecific general stimulating effect on the body. Increases the body's adaptive abilities and its resistance to infections; promotes regeneration processes.

Pharmacokinetics

Absorbed in the gastrointestinal tract (mainly in the jejunum). With an increase in dose to 200 mg, up to 140 mg (70%) is absorbed; at further increase dose absorption decreases (50-20%). Protein binding - 25%. Gastrointestinal diseases (peptic ulcer of the stomach and duodenum, constipation or diarrhea, helminthic infestation, giardiasis), consumption of fresh fruit and vegetable juices, alkaline drinking reduce the absorption of ascorbic acid in the intestine.

The normal concentration of ascorbic acid in plasma is approximately 10-20 mcg/ml, body reserves are about 1.5 g when taking daily recommended doses and 2.5 g when taking 200 mg/day. The time to reach Cmax after oral administration is 4 hours.

Easily penetrates into leukocytes, platelets, and then into all tissues; the highest concentration is achieved in the glandular organs, leukocytes, liver and lens of the eye; penetrates the placenta. The concentration of ascorbic acid in leukocytes and platelets is higher than in erythrocytes and plasma. In deficiency states, leukocyte concentrations decline later and more slowly and are considered a better measure of deficiency than plasma concentrations.

Metabolized primarily in the liver into deoxyascorbic acid and further into oxaloacetic acid and ascorbate-2-sulfate.

Excreted by the kidneys, through the intestines, with sweat, breast milk unchanged and in the form of metabolites.

When high doses are prescribed, the rate of elimination increases sharply. Smoking and drinking ethanol accelerate the destruction of ascorbic acid (conversion into inactive metabolites), sharply reducing reserves in the body.

Excreted during hemodialysis.

Indications

• prevention and treatment of hypo- and avitaminosis C;
• states of increased need for ascorbic acid;
• period of artificial feeding and intensive growth;
• unbalanced diet;
• increased mental and physical stress;
• period of convalescence after serious illnesses;
• alcoholism;
• burn disease;
• febrile state against the background of acute respiratory diseases, acute respiratory viral infections;
• long-term chronic infections;
• nicotine addiction;
• stressful state;
• postoperative period, pregnancy (multiple, due to nicotine or drug addiction);
• chronic intoxication with iron preparations (as part of complex therapy with deferoxamine);
• idiopathic methemoglobinemia.

Contraindications

• thrombophlebitis;
• tendency to thrombosis;
• diabetes;
• sucrase/isomaltase deficiency, fructose intolerance,
  glucose-galactose malabsorption;
• increased sensitivity.

WITH caution: hyperoxalaturia, renal failure, hemochromatosis, thalassemia, polycythemia, leukemia, sideroblastic anemia, glucose-6-phosphate dehydrogenase deficiency, sickle cell anemia, progressive malignant diseases.

Dosage

The drug is taken orally after meals.

For prevention:adults 0.05-0.1 g (1-2 tablets)/day, children from 5 years old - 0.05 g (1 tablet)/day.

For treatment: adults 0.05-0.1 g (1-2 tablets) 3-5 times/day, children from 5 years old

At pregnancy and lactation- 0.3 g (6 tablets)/day for 10-15 days, then 0.1 g (2 tablets)/day.

Side effects

If any side effects occur, you should stop taking the drug and consult a doctor.

From the side of the central nervous system: headache, feeling of fatigue, with prolonged use of large doses - increased excitability of the central nervous system, sleep disturbances.

From the digestive system: irritation of the gastrointestinal mucosa, nausea, vomiting, diarrhea, stomach cramps.

From the endocrine system: inhibition of the function of the insular apparatus of the pancreas (hyperglycemia, glycosuria).

From the urinary system: when used in high doses - hyperoxalaturia and the formation of urinary stones and calcium oxalate.

From the cardiovascular system: thrombosis, when used in high doses, increased blood pressure, development of microangiopathy, myocardial dystrophy.

Allergic reactions: skin rash; rarely - anaphylactic shock.

Laboratory indicators: thrombocytosis, hyperprothrombinemia, erythropenia, neutrophilic leukocytosis, hypokalemia.

Others: hypovitaminosis, feeling of heat, with prolonged use of large doses - sodium (Na +) and fluid retention, impaired metabolism of zinc (Zn 2+), copper (Cu 2+).

Overdose

Symptoms: when taking more than 1 g/day, heartburn, diarrhea, difficulty urinating or red coloration of urine, and hemolysis are possible. (in patients with glucose-6-phosphate dehydrogenase deficiency).

Treatment: symptomatic, forced diuresis.

Drug interactions

Increases the concentration of tetracyclines in the blood; at a dose of 1 g/day increases the bioavailability of ethinyl estradiol.

Improves the absorption of iron preparations in the intestines (converts ferric iron to divalent iron); may increase iron excretion when used concomitantly with deferoxamine.

(ASA), oral contraceptives, fresh juices and alkaline drinks reduce absorption and absorption.

When used simultaneously with ASA, the excretion of ascorbic acid in the urine increases and the excretion of ASA decreases. ASA reduces the absorption of ascorbic acid by approximately 30%.

Increases the risk of developing crystalluria during treatment with salicylates and short-acting sulfonamides, slows down the secretion of acids by the kidneys, increases the excretion of drugs that have an alkaline reaction (including alkaloids), and reduces the concentration of oral contraceptives in the blood.

Increases the overall clearance of ethanol, which, in turn, reduces the concentration of ascorbic acid in the body.

Quinoline drugs (fluoroquinolones, etc.), salicylates, corticosteroids, when used for a long time, deplete ascorbic acid reserves.

When used simultaneously, it reduces the chronotropic effect of isoprenaline.

Long-term use or use in high doses may interfere with the disulfiram-ethanol interaction.

In high doses, it increases the renal excretion of mexiletine.

Barbiturates and primidone increase the excretion of ascorbic acid in the urine.

Reduces the therapeutic effect of antipsychotics (phenothiazine derivatives), tubular reabsorption of amphetamine and tricyclic antidepressants.

special instructions

Due to the stimulating effect of ascorbic acid on the synthesis of corticosteroid hormones, it is necessary to monitor kidney function and blood pressure

With long-term use of large doses, inhibition of the function of the pancreatic insular apparatus is possible, so it must be regularly monitored during treatment.

In patients with high iron levels in the body, ascorbic acid should be used in minimal doses.

Prescribing ascorbic acid to patients with rapidly proliferating and intensively metastasizing tumors can aggravate the process.

Ascorbic acid, as a reducing agent, can distort the results of various laboratory tests (blood glucose, bilirubin, transaminase activity, lactate dehydrogenase).

Impact on the ability to drive vehicles and operate machinery

Ascorbic acid does not affect the speed of psychomotor reactions when driving a car or working with precision mechanisms.

Pregnancy and lactation

The minimum daily requirement for ascorbic acid in the II-III trimesters of pregnancy is about 60 mg.

The minimum daily requirement during lactation is 80 mg. A mother's diet containing adequate amounts of ascorbic acid is sufficient to prevent vitamin C deficiency in an infant (it is recommended that a nursing mother not exceed the maximum daily requirement for ascorbic acid).

Use in childhood

For prevention: children from 5 years old - 0.05 g (1 tablet)/day.

For treatment:children from 5 years old- 0.05-0.1 g (1-2 tablets) 2-3 times/day.

Conditions for dispensing from pharmacies

The drug is approved for use as a means of OTC.

Storage conditions and periods

Store the drug in a dry place, protected from light, at a temperature not exceeding 25°C.

Keep out of the reach of children.

Shelf life - 1 year 6 months.

Do not use after the date indicated on the package

The summer sunny days are over. The autumn season is coming, which will bring with it rains, dampness, and therefore a runny nose, colds, and coughs. The main thing is to have all the necessary cold remedies on hand. They can be either in powders or in dragees. It is very important during this period to strengthen your immunity and prepare your body to fight viruses. The best way To do this, take vitamins, which are also available in tablets. Wondering how to take pills correctly?

What is a dragee

Dragee is one of the types medicines. Children's medicines and vitamins are often produced in the form of dragees.

• The difference between dragees and regular tablets is their dense, sweet shell.
• They are coated with a layer of sugar, chocolate or other substance that can mask the bitter taste of the drug.
• The sweet layer hermetically covers the tablet and preserves everything active ingredients even when exposed to air. For example, in uncoated tablets, interaction with air leads to a change in the composition of iron in the drug.

Drugs that are difficult to produce in tablet form are produced in the form of dragees. They hide the unpleasant taste, pills are easier to take than tablets and capsules, they are easy to swallow, but they have their drawbacks. Dragee is very difficult to dose. They take longer to break down and are more difficult to remove from the body. Dragees are not prescribed for children.

How to take pills correctly

The dosage and timing of use of medications is prescribed by the doctor in accordance with the disease.

1. The pills are taken two to three times a day before meals.
2. If symptoms such as nausea and vomiting occur during meals, you can change the time of administration and take the medications several hours after eating.
3. Drugs in the form of pills disintegrate in the gastrointestinal tract after 30 minutes.

Dragee is a common form of vitamin production. These drugs can be given to children.

• Dosage and methods of administration depend on the type of vitamin.
• Multivitamins are taken once a day before meals with plenty of water.
• The most famous and beloved vitamins from childhood, for example ascorbic acid, are taken up to three times a day during illness, and once a day as a preventive measure.

Ascorbic acid can cause unpleasant symptoms and lead to the development of allergic reactions, so it must be taken strictly according to the instructions.

Ascorbic acid (Vitamin C) is a drug in the form of pills, widespread since Soviet times, which is familiar to every family under the name “ascorbic acid”. A person cannot synthesize this vitamin, so the necessary supply in the body is replenished with food intake. The drug is obtained synthetically.

Ascorbic acid is a drug common since Soviet times, which is familiar to every family under the name “ascorbic acid”.

International nonproprietary name

In Latin the drug is called Acidum ascorbinicum.

ATX and registration number

ATC code A11GA01 Vitamin C. Registration number LP-001641 dated 04/09/12

Pharmacotherapeutic group

Ascorbic acid belongs to the group of water-soluble substances. Vitamin preparations are especially important in old age, for pregnant women, under increased stress, for children during a period of rapid growth, when the process of tissue regeneration occurs, etc.

Mechanism of action

Has activity: antioxidant, regulating redox processes, metabolic, replenishing vitamin C deficiency.

Participating:

• in the functioning of enzymes that play an important role in the formation of collagen (catalyze the hydroxylation of lysine and proline);
• in the formation of norepinephrine;
• V metabolic processes cholesterol, catecholamines and steroid hormones.

Absorbed in the gastrointestinal tract (mainly in the jejunum), and excreted by the kidneys, through the intestines, with sweat, breast milk unchanged and in the form of metabolic products.

Compound

The active ingredient is vitamin C. Available in the form of dragees, 1 pc. which also contains a certain amount of auxiliary substances: starch molasses, sugar, wax, mineral oil, talc, fruit flavorings.

Package

Dragee is packaged in a polymer jar of 100 or 200 pieces, and then in a cardboard box.

What are the benefits of Ascorbic acid?

For alcoholism

Ascorbic acid is actively used in the complex, because it promotes the removal of alcohol from the body and protects.

Treatment is combined with psychotherapy and a complete ban on drinking alcohol.

Treatment takes place in 2 stages:

1. At the first stage, it is carried out, in which vitamin C is used together with other drugs. Tranquilizers are often prescribed. The patient is given plenty of water mineral waters, juices, compotes and give diuretics. Provide enhanced nutrition.
2. When a good state, mental and somatic, is achieved, stage 2 is carried out - anti-alcohol treatment using one of the following methods:
   • conditioned reflex therapy;
   • therapy;
   • group rational therapy;

Upon discharge, the doctor tells you what to do to avoid a breakdown - a return to drinking.

For a hangover

Alcohol compatibility

Ascorbic acid increases and accelerates the elimination of ethanol from the body, which, in turn, reduces the concentration of acid in the body. May affect the effectiveness of treatment.

Conditions for dispensing from pharmacies

Over-the-counter release.

Price

A jar of 50 mg tablets of Ascorbic acid costs 20-25 rubles, and a package of 25 mg tablets, which contain glucose, costs about 10-20 rubles.

Storage conditions

The drug is stored in a dry place, protected from light and out of reach of children, at temperatures up to 25°C.

Best before date

With iodine

With lecithin

All mothers know about the benefits of vitamin C, so attention is paid to its entry into the child’s body from birth, creating a rational menu for the baby. If it is not possible to provide the child with a sufficient amount of ascorbic acid in food, they resort to vitamin supplements. From what age is it permissible to give pharmaceutical preparations with vitamin C to prevent its deficiency and for what diseases are they needed? childhood?

Release form

Ascorbic acid is produced:

• In tablets. These round tablets may be white, pink, orange or another color depending on the composition. They include 25 mg or 100 mg of ascorbic acid, but also produce a preparation with 50 mg, 75 mg, 300 mg or 500 mg of this vitamin compound. One pack contains 10, 50 or 100 tablets.
• In jelly beans. Often these are small spherical yellow vitamins. Each tablet contains 50 mg of vitamin. One package contains 50, 100, 150 or 200 tablets.
• In ampoules. This form of ascorbic acid is intended for administration into a vein or intramuscular injection. This is a 5% or 10% transparent solution, bottled in 1 or 2 ml ampoules. One package includes 5 or 10 ampoules.
• In powder. A solution is prepared from it, which must be taken orally. The powder is colorless or white crystals that have no odor. It is packaged in bags of 1 or 2.5 g. One pack contains from 5 to 100 such bags.

Compound

The powder form contains only ascorbic acid. In addition to the main substance, tablets and dragees may contain sucrose, wax, calcium stearate, dye, dextrose, starch, lactose, talc, crospovidone and other auxiliary ingredients. In addition to vitamin C, the injection form may contain water, sodium sulfite and bicarbonate, cysteine, and disodium edetate.

Operating principle

Once in the body, ascorbic acid has the following effect:

• Normalizes the permeability of small vessels.
• Protects cells and tissues from toxic substances (antioxidant effect).
• Strengthens the defenses, preventing viral infections and colds by activating the formation of antibodies and interferon.
• Helps absorb glucose.
• Has a positive effect on liver functions.
• Regulates blood clotting.
• Accelerates skin healing in case of damage.
• Participates in the formation of collagen.
• Helps absorb iron and folic acid.
• Activates digestive enzymes, improves bile secretion, pancreas and thyroid function.
• Reduces the manifestations of allergies and inflammation by inhibiting the formation of mediators involved in these pathological processes.

How vitamin C affects the body and what are the indications and contraindications for the use of ascorbic acid - watch in a short video:

Indications

• If his diet is unbalanced and there is a risk of hypovitaminosis.
• During the active growth of the child's body.
• To prevent ARVI. This reason is relevant in autumn, during winter cold and early spring.
• If the child has increased emotional or physical stress.
• If your baby is recovering from injury or surgery.

WITH therapeutic purpose Vitamin C preparations are prescribed:

• With diagnosed hypovitaminosis C.
• With hemorrhagic diathesis.
• For nosebleeds and other bleeding.
• At infectious diseases or intoxication.
• With excessive use of iron supplements for a long time.
• For acute radiation sickness.
• For anemia.
• For liver pathologies.
• For colitis, peptic ulcer, enteritis or achylia.
• For cholecystitis.
• With sluggish healing of burns, ulcers or wounds on the skin.
• For bone fractures.
• With dystrophy.
• For helminthiasis.
• For chronic dermatoses and some other skin diseases.

At what age can it be given?

Give medications with ascorbic acid one year old child it is forbidden. Tablets containing 25 mg of ascorbic acid are prescribed from 3 years of age. Dragees containing the vitamin in a dose of 50 mg are prescribed for children over 5 years of age.

Such age restrictions associated with difficulty swallowing the drug in early age, as well as the risk of inhaling the pills. If necessary, your doctor can prescribe vitamin C earlier, but you should not do this on your own. Even when the child is already 3 years old or older, you should consult your pediatrician about the use of such a vitamin.

Contraindications

Instructions for use prohibit ascorbic acid in the following cases:

• If the patient has an intolerance to such a vitamin.
• If there is a tendency to thrombosis or thrombophlebitis is detected.
• If the child has diabetes (for forms with sugar).
• If the blood test showed too high level hemoglobin.
• If a young patient is diagnosed with severe renal pathology.

Side effects

Sometimes a child’s body reacts to taking ascorbic acid with an allergy. These are often skin changes that manifest themselves as redness, itching, and rashes.

Treatment with vitamin C may also lead to:

• Thrombocytosis, erythropenia, leukocytosis due to neutrophils.
• Weakness and dizziness (if injected into a vein too quickly).
• Diarrhea (at high dosage).
• Nausea or vomiting.
• Damage to tooth enamel (with prolonged absorption in the mouth).
• Fluid and sodium retention.
• Formation of oxalate stones in the urinary tract (with long-term use of high doses).
• Disruption of metabolic processes.
• Kidney damage.
• Pain at the injection site (if administered intramuscularly).

Instructions for use and dosage

• Ascorbic acid tablets with glucose or dragees are offered to the child after meal.
• Prophylactic dose for children 3-10 years old it is represented by 1 tablet containing 25 mg of vitamin, and over the age of ten years this daily dosage is increased to two tablets (50 mg per day).
• Treatment dose is 2 tablets of 25 mg of ascorbic acid per day under the age of 10 years (daily dosage 50 mg) and three to four tablets of the drug over the age of 10 years (daily dosage 75-100 mg).
• It is recommended to take ascorbic acid prophylactically from two weeks to two months. The duration of the treatment course is determined by the doctor.
• If the dosage of the active substance in a tablet is 100 mg, then this ascorbic acid is given in a dose of 1/2 tablet per day to children over 6 years of age.
• Dragees are given for prevention to children over five years old, 1 piece per day, and for treatment - 1-2 dragees up to 3 times a day.
• Only a doctor should prescribe Ascorbic acid in injections to children. The daily dosage is 1-2 ml of the drug, but a more precise dose, route of administration and duration of therapy should be determined by a specialist, taking into account the disease in a particular child.

Overdose

Since ascorbic acid is a water-soluble compound, hypervitaminosis does not develop with an excessive dosage of this vitamin. However, excessively high doses of such a substance can damage the mucous membrane of the stomach and intestines, which leads to abdominal pain, diarrhea, bloating, vomiting and other negative symptoms.

Also, poisoning with a very large amount of vitamin C is manifested by weakness, sweating, hot flashes, insomnia, and headaches. In addition, an excess of this substance will reduce capillary permeability, which will impair tissue nutrition, increase blood pressure and can lead to hypercoagulation.

To prevent ascorbic acid from causing illness, you should be aware of the maximum recommended dosages of this vitamin:

• For children under 3 years old this is 400 mg per day.
• For a child aged 4 to 8 years, the maximum dose per day is 600 mg.
• For children 9 to 13 years of age, dosage should not exceed 1200 mg per day.
• At the age of over 14 years, the permissible maximum ascorbic acid per day is 1800 mg of this vitamin.

Watch an educational video that explains what can happen if you allow excess vitamin C in the body:

Interaction with other drugs

• The use of ascorbic acid will increase the blood levels of penicillin and tetracycline antibiotics, as well as salicylates.
• When taking vitamin C and acetylsalicylic acid together, the absorption of ascorbic acid worsens. The same effect is observed if you drink ascorbic acid with an alkaline liquid or fresh juice.
• Simultaneous use with anticoagulants will reduce their therapeutic effect.
• Taking vitamin C together with iron supplements promotes better absorption of Fe in the intestines. If you prescribe ascorbic acid and deferoxamine, iron toxicity will increase, which will negatively affect the heart and its function.
• To mix injection form Vitamin C in the same syringe with any medications is not recommended, since many drugs enter into chemical reactions with ascorbic acid.
• With simultaneous treatment with barbiturates, the excretion of ascorbic acid in the urine increases.

Terms of sale

You do not need a prescription to purchase Ascorbic Acid in pharmacies. The price of 10 ampoules of 2 ml with a 5% solution of ascorbic acid is about 40 rubles. A jar of 50 mg tablets of vitamin C costs 20-25 rubles, and a package of 25 mg tablets, which contain glucose, costs about 10-20 rubles.

Storage conditions and shelf life

The place where you need to place Ascorbic acid for better preservation should not be very humid, hot or lit. In addition, you need to keep the drug where small children cannot reach it.

The shelf life of tablets with ascorbic acid is 1-3 years from different manufacturers, a 5% solution for injections is stored for up to a year, a 10% solution and dragees are stored for 18 months from the date of release.